Results 91 to 100 of about 15,320 (194)

Activation and Desensitization of Peripheral Muscle and Neuronal Nicotinic Acetylcholine Receptors by Selected, Naturally-Occurring Pyridine Alkaloids

Toxins, 2016
Teratogenic alkaloids can cause developmental defects due to the inhibition of fetal movement that results from desensitization of fetal muscle-type nicotinic acetylcholine receptors (nAChRs).
Benedict T. Green, Stephen T. Lee, Kevin D. Welch, Daniel Cook, William R. Kem   +4 more
doaj   +1 more source

Semisynthetic Analogues of Toxiferine I and Their Pharmacological Properties at α7 nAChRs, Muscle-Type nAChRs, and the Allosteric Binding Site of Muscarinic M₂ Receptors

, 2015
A new series of analogues of the calabash curare alkaloid toxiferine I was prepared and pharmacologically evaluated at α7 and muscle-type nAChRs and the allosteric site of muscarinic M2 receptors.
Daniela Gündisch (1336926), Anders A. Jensen (709631), Christian Tränkle (1336929), Ulrike Holzgrabe (824342), Darius P. Zlotos (1336923)   +4 more
core   +1 more source

Concentrations-response relationships of ACh for D. melanogaster nAChRs expressed in X. laevis oocytes and actions of α-BTX on the ACh-induced responses of nAChRs.

, 2023
(A) Concentration-response curves of ACh and (B) heatmap representing α-BTX for the 12 nAChRs expressed in X. laevis oocytes. In (A), each data plot indicates the mean ± standard error (n = 5).
Daitaro Misawa (14636351), Ryusuke Niwa (141031), David B. Sattelle (10519773), Makoto Ihara (728629), Kazuhiko Matsuda (353746), Wataru Koizumi (14636348), Shu Kondo (769011), Kotaro Kamiya (14636354), Masaki Kamiya (2464480), Naoki Okamoto (400062), Koichi Takayama (95125), Kazuki Seike (14636357), Hiromu Tanimoto (151954), Yuma Komori (11869287), Yuto Yoshinari (5782886)   +14 more
core   +1 more source

Diabetes Depresses Synaptic Transmission in Sympathetic Ganglia by Inactivating nAChRs through a Conserved Intracellular Cysteine Residue

, 2010
SummaryMost people with diabetes develop severe complications of the autonomic nervous system; yet, the underlying causes of many diabetic-induced dysautonomias are poorly understood.
Ellis Cooper, Verónica Campanucci, Arjun Krishnaswamy, Campanucci, Verónica, Krishnaswamy, Arjun, Cooper, Ellis   +5 more
core   +1 more source

Learning and nicotine interact to increase CREB phosphorylation at the jnk1 promoter in the hippocampus

, 2012
Nicotine is known to enhance long-term hippocampus dependent learning and memory in both rodents and humans via its activity at nicotinic acetylcholinergic receptors (nAChRs).
Rachel L Poole, Gould, Thomas J., Michael D Adoff, Gould Thomas J., Kenney, Justin W., Thomas J Gould, Poole Rachel L., Poole, Rachel L., Logue, Sheree F., Kenney Justin W., Justin W Kenney, Sheree F Logue, Logue Sheree F., Adoff, Michael D., Adoff Michael D.   +14 more
core   +1 more source

New insights on neuronal nicotinic acetylcholine receptors as targets for pain and inflammation: A focus on α7 nAChRs

, 2017
Background: Nicotine and nicotinic acetylcholine receptors (nAChRs) have been explored for the past three decades as targets for pain control. The aim of this review is to introduce readers particularly to alpha 7 nAChRs in a perspective of pain and its ...
Papke, Roger L., Damaj, M. Imad, Flood, Pamela   +2 more
core   +1 more source

α3β4-myc nAChRs localize to the apical cell surface and colocalize with F-actin and Arp3.

, 2013
Monolayers of Caco-2 cells expressing α3β4-myc nAChRs were fixed, surface labeled with anti-myc antibodies, permeabilized, and colabeled with anti-α-catenin (A), Alexa-488 phalloidin (B), and anti-Arp3 (C) antibodies.
Juan L. Brusés (406197)
core   +1 more source

Effects of soluble β-amyloid on the release of neurotransmitters from rat brain synaptosomes.

Frontiers in Aging Neuroscience, 2014
Contradictory results have been reported on the interaction of beta-amyloid (Aβ) with cholinergic receptors. The present paper investigates the modulatory effect of Aβ1-40 on the neurotransmitter release evoked by nicotinic (nAChRs) and muscarinic ...
Guendalina eOlivero, Massimo eGrilli, Jiayang eChen, Stefania ePreda, Elisa eMura, Stefano eGovoni, Mario eMarchi   +6 more
doaj   +1 more source

Nicotine acetylcholine receptors: a comparison of the nAChRs of Caenorhabditis elegans and parasitic nematodes

, 2013
Nicotinic acetylcholine receptors (nAChRs) play a key role in the normal physiology of nematodes and provide an established target site for anthelmintics.
O'Connor, V., Holden-Dye, L., Walker, R., Joyner, M.   +3 more
core   +1 more source

Summary analysis of Ric-3-mediated proteins with literature citations implicating functional interactions with nAChRs.

, 2015
Summary analysis of Ric-3-mediated proteins with literature citations implicating functional interactions with nAChRs.
Ronald J. Lukas (781724), Francisco J. Barrantes (565255), Sydney B. Blattman (781723), Edward Hawrot (781725), Matthew J. Mulcahy (781722)   +4 more
core   +1 more source