Results 111 to 120 of about 20,678 (180)

Gene therapy for epilepsy: An emerging, promising approach for a serious neurological disorder

Journal of Internal Medicine, Volume 299, Issue 3, Page 302-327, March 2026.
Abstract Gene therapy is emerging as a groundbreaking strategy for treating epilepsy, offering new hope to patients who do not respond to conventional medications. Despite advancements in anti‐seizure treatments, nearly 30%–40% of individuals with epilepsy continue to experience uncontrolled seizures, highlighting the urgent need for more effective and
Marco Ledri, Merab Kokaia
wiley   +1 more source

Understanding Nicotine Addition: Dependency as a Result of Maladaptive Brain Structure [PDF]

, 2014
Nicotine addiction is the most prevalent, destructive dependency found in our culture. Despite its well-documented damaging health risks, nicotine use is still widely accepted and could be conceptualized as a social epidemic.
Thomas, Nate
core   +1 more source

Cardioprotection via vagus nerve stimulation preconditioning: Reducing ischaemia–reperfusion injury and arrhythmic risk

Experimental Physiology, Volume 111, Issue 3, Page 714-726, 1 March 2026.
Abstract Acute myocardial infarction is a leading cause of morbidity and mortality, with ischaemia–reperfusion (I/R) injury exacerbating myocardial damage. Vagus nerve stimulation (VNS) has been reported to exert cardioprotective effects, but its efficacy in preconditioning against I/R injury requires further investigation.
Feng Hu, Yali Wang, Guangyu Li, Guangyu Wang, Qi Zhuang, Jinyao Jiang, Danfeng Hu, Lihui Zheng, Yan Yao, Minhua Zang, Jun Pu   +10 more
wiley   +1 more source

Nicotinic α7 receptors on cholinergic neurons in the striatum mediate cocaine-reinforcement, but not food reward

Frontiers in Molecular Neuroscience
The neurotransmitter acetylcholine has since long been implicated in reward learning and drug addiction. However, the role of specific cholinergic receptor subtypes on different neuronal populations remain elusive.
Michael Fritz, Michael Fritz, Michael Fritz, Priscila Batista Rosa, Daniel Wilhelms, Daniel Wilhelms, Maarit Jaarola, Johan Ruud, David Engblom, Anna M. Klawonn, Anna M. Klawonn, Anna M. Klawonn, Anna M. Klawonn   +12 more
doaj   +1 more source

Abundant extrasynaptic expression of α3β4-containing nicotinic acetylcholine receptors in the medial habenula–interpeduncular nucleus pathway in mice

Scientific Reports
Nicotinic acetylcholine receptors (nAChRs) in the medial habenula (MHb)–interpeduncular nucleus (IPN) pathway play critical roles in nicotine-related behaviors.
Asuka Tsuzuki, Miwako Yamasaki, Kohtarou Konno, Taisuke Miyazaki, Norio Takei, Susumu Tomita, Michisuke Yuzaki, Masahiko Watanabe   +7 more
doaj   +1 more source

Chimeric Approach to Identify Molecular Determinants of Nicotinic Acetylcholine Receptors. [PDF]

Int J Mol Sci
Sapkota P, Akaberi SM, Ghimire B, Sharma K.   +3 more
europepmc   +1 more source

Synchronous activation of striatal cholinergic interneurons induces local serotonin release. [PDF]

Nat Commun
Matityahu L, Hobel ZB, Berkowitz N, Malgady JM, Gilin N, Plotkin JL, Goldberg JA.   +6 more
europepmc   +1 more source

Dual Agonist/Antagonist Modulation of α9-Containing Nicotinic Acetylcholine Receptors by 2-Ammoniumethyl Ethers of Stilbenol and Stilbenol Analogues. [PDF]

J Med Chem
Giraudo A, Tae HS, Hung A, Richter K, Shivankar B, Armano E, Grau V, Pallavicini M, Adams DJ, Bolchi C.   +9 more
europepmc   +1 more source

Nicotinic Receptors in the Medial Habenula to Interpeduncular Nucleus Pathway: Modulators of Reward, Aversion and Emotion. [PDF]

Eur J Neurosci
Ciscato M, Chouvaeff M, Mourot A.
europepmc   +1 more source

Cholinergic signaling differentially regulates a vocal motor pallial nucleus to stabilize adult birdsong. [PDF]

Commun Biol
Xu N, Zhang Y, Sun Y, Song X, Cao Y, Yang X, Zhou Y, Meng W.   +7 more
europepmc   +1 more source