Results 1 to 10 of about 299,285 (291)
Inhibition of pigeon liver NAD kinase by a non‐phosphorylatible analogue of NAD [PDF]
FEBS Letters, 1971 Nicotinamide-2’-deoxy-adenosine dinucleotide tNdAD) has previously been prepared enzymatically [ 11 and chemically [2] , and its interactions with dehydrogenases were studied. Since this analogue of NAD differs from the natural coenzyme in lacking the 2’-hydroxyl on the adenosine ribose, it cannot be phosphorylated by NAD kinase (ATP:NAD 2 ...
David K. Apps
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CycloZ Improves Hyperglycemia and Lipid Metabolism by Modulating Lysine Acetylation in KK-Ay Mice [PDF]
Diabetes & Metabolism Journal, 2023 Background CycloZ, a combination of cyclo-His-Pro and zinc, has anti-diabetic activity. However, its exact mode of action remains to be elucidated.
Jongsu Jeon +15 more
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“NAD-capQ” detection and quantitation of NAD caps [PDF]
RNA, 2018 RNA 5′ cap structures comprising the metabolic effector nicotinamide adenine dinucleotide (NAD) have been identified in diverse organisms. Here we report a simple, two-step procedure to detect and quantitate NAD-capped RNA, termed “NAD-capQ.” By use of NAD-capQ we quantitate NAD-capped RNA levels in Escherichia coli, Saccharomyces cerevisiae, and human
Jeremy G. Bird +3 more
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Conceptual framework for SARS-CoV-2–related lymphopenia
Advanced Biomedical Research, 2022 The emerging of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak is associated with high morbidity and mortality rates globally. One of the most prominent characteristics of coronavirus disease-19 (COVID-19) is lymphopenia, which is ...
Ilnaz Rahimmanesh +3 more
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Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Impaired neuronal bioenergetics and neuroinflammation are thought to play key roles in the progression of Alzheimer's disease (AD), but their interplay is not clear.
Yujun Hou +8 more
semanticscholar +1 more source
NAD+ metabolism, stemness, the immune response, and cancer
Signal Transduction and Targeted Therapy, 2021 NAD + was discovered during yeast fermentation, and since its discovery, its important roles in redox metabolism, aging, and longevity, the immune system and DNA repair have been highlighted.
L. Navas, A. Carnero
semanticscholar +1 more source
Mitochondrial dysfunction at the cornerstone of inflammatory exacerbation in aged macrophages
Exploration of Immunology, 2023 Immunosenescence encompasses multiple age-related adaptations that result in increased susceptibility to infections, chronic inflammatory disorders, and higher mortality risk.
Rafael Moura Maurmann +3 more
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Nicotinamide adenine dinucleotide (NAD+). Formal potential of the NAD+/NAD· couple and NAD· dimerization rate [PDF]
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1984 The rate constant, kd, for the dimerization of the free radical (NAD), produced on the initial one-electron reduction of NAD+, was measured by double potential-step chronoamperometry, fast-scan cyclic voltammetry (cathodic-anodic peak current ratio) and slow-scan cyclic voltammetry (peak potential shift) for a medium in which neither NAD+ nor its ...
Mark A. Jensen, Philip J. Elving
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NAD-seq for profiling the NAD+ capped transcriptome of Arabidopsis thaliana
STAR Protocols, 2021 Eukaryotic RNAs can be modified with a non-canonical 5' nicotinamide adenine dinucleotide (NAD+) cap. NAD-seq identifies transcriptome-wide NAD+ capped RNAs. NAD-seq takes advantage of click chemistry to allow the capture of NAD+ capped RNAs. Unlike other approaches, NAD-seq does not require DNA synthesis on beads, but this technique uses full NAD ...
Xiang Yu +2 more
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Enfermedad del coronavirus (covid-19) y las sirtuinas
Revista de la Facultad de Ciencias Médicas de Córdoba, 2020 Las proteínas desacetilasas dependientes del NAD+, se denominan Sirtuinas (SIRT). Objetivos: estudiar las sirtuinas involucradas en el cáncer, así como los estudios de inhibición de SIRT1 en pacientes con la enfermedad del coronavirus COVID-19 ...
Ronald Eleazar Huarachi Olivera +1 more
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