Results 1 to 10 of about 1,064,600 (267)
CycloZ Improves Hyperglycemia and Lipid Metabolism by Modulating Lysine Acetylation in KK-Ay Mice [PDF]
Diabetes & Metabolism Journal, 2023 Background CycloZ, a combination of cyclo-His-Pro and zinc, has anti-diabetic activity. However, its exact mode of action remains to be elucidated.
Jongsu Jeon +15 more
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Conceptual framework for SARS-CoV-2–related lymphopenia
Advanced Biomedical Research, 2022 The emerging of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak is associated with high morbidity and mortality rates globally. One of the most prominent characteristics of coronavirus disease-19 (COVID-19) is lymphopenia, which is ...
Ilnaz Rahimmanesh +3 more
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NAD metabolism: Role in senescence regulation and aging
Aging Cell, 2023 The geroscience hypothesis proposes that addressing the biology of aging could directly prevent the onset or mitigate the severity of multiple chronic diseases.
Claudia C S Chini +3 more
semanticscholar +1 more source
NAD+ Homeostasis and NAD+-Consuming Enzymes: Implications for Vascular Health
Antioxidants, 2023 Nicotinamide adenine dinucleotide (NAD+) is a ubiquitous metabolite that takes part in many key redox reactions. NAD+ biosynthesis and NAD+-consuming enzymes have been attracting markedly increasing interest since they have been demonstrated to be ...
R. Campagna, A. Vignini
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Impaired neuronal bioenergetics and neuroinflammation are thought to play key roles in the progression of Alzheimer's disease (AD), but their interplay is not clear.
Yujun Hou +8 more
semanticscholar +1 more source
Mitochondrial dysfunction at the cornerstone of inflammatory exacerbation in aged macrophages
Exploration of Immunology, 2023 Immunosenescence encompasses multiple age-related adaptations that result in increased susceptibility to infections, chronic inflammatory disorders, and higher mortality risk.
Rafael Moura Maurmann +3 more
doaj +1 more source
NAD+ metabolism, stemness, the immune response, and cancer
Signal Transduction and Targeted Therapy, 2021 NAD + was discovered during yeast fermentation, and since its discovery, its important roles in redox metabolism, aging, and longevity, the immune system and DNA repair have been highlighted.
L. Navas, A. Carnero
semanticscholar +1 more source
Enfermedad del coronavirus (covid-19) y las sirtuinas
Revista de la Facultad de Ciencias Médicas de Córdoba, 2020 Las proteínas desacetilasas dependientes del NAD+, se denominan Sirtuinas (SIRT). Objetivos: estudiar las sirtuinas involucradas en el cáncer, así como los estudios de inhibición de SIRT1 en pacientes con la enfermedad del coronavirus COVID-19 ...
Ronald Eleazar Huarachi Olivera +1 more
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CD38 in Neurodegeneration and Neuroinflammation
Cells, 2020 Neurodegenerative diseases are characterized by neuronal degeneration as well as neuroinflammation. While CD38 is strongly expressed in brain cells including neurons, astrocytes as well as microglial cells, the role played by CD38 in neurodegeneration ...
Serge Guerreiro +3 more
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Medicine Science, 2020 Tuberculosis is an infectious disease, which is caused by the Mycobacterium tuberculosis complex. This disease leads to up to 1.3 million deaths out of more than eight million cases every year.
Selami Gunal +2 more
doaj +1 more source