Results 1 to 10 of about 923,736 (263)

Maternal Circulatory NAD Precursor Levels and the Yolk Sac Determine NAD Deficiency-Driven Congenital Malformation Risk. [PDF]

FASEB J
Maternal circulatory L‐tryptophan (TRP) and nicotinamide (NAM) levels are proportional to dietary TRP intake. Yolk sacs, but not embryos, perform NAD de novo synthesis. This study explores the exchange of NAD precursors between mother and conceptus, and NAD generation in conceptal tissues via the NAD de novo synthesis (blue) or salvage (red) pathways ...
Bozon K, Cuny H, Sheng DZ, Sipka A, Shand AW, Nassar N, Dunwoodie SL.   +6 more
europepmc   +2 more sources

CycloZ Improves Hyperglycemia and Lipid Metabolism by Modulating Lysine Acetylation in KK-Ay Mice [PDF]

Diabetes & Metabolism Journal, 2023
Background CycloZ, a combination of cyclo-His-Pro and zinc, has anti-diabetic activity. However, its exact mode of action remains to be elucidated.
Jongsu Jeon, Dohyun Lee, Bobae Kim, Bo-Yoon Park, Chang Joo Oh, Min-Ji Kim, Jae-Han Jeon, In-Kyu Lee, Onyu Park, Seoyeong Baek, Chae Won Lim, Dongryeol Ryu, Sungsoon Fang, Johan Auwerx, Kyong-Tai Kim, Hoe-Yune Jung   +15 more
doaj   +1 more source

Conceptual framework for SARS-CoV-2–related lymphopenia

Advanced Biomedical Research, 2022
The emerging of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak is associated with high morbidity and mortality rates globally. One of the most prominent characteristics of coronavirus disease-19 (COVID-19) is lymphopenia, which is ...
Ilnaz Rahimmanesh, Shirin Kouhpayeh, Yadollah Azizi, Hossein Khanahmad   +3 more
doaj   +1 more source

Mitochondrial dysfunction at the cornerstone of inflammatory exacerbation in aged macrophages

Exploration of Immunology, 2023
Immunosenescence encompasses multiple age-related adaptations that result in increased susceptibility to infections, chronic inflammatory disorders, and higher mortality risk.
Rafael Moura Maurmann, Brenda Landvoigt Schmitt, Negin Mosalmanzadeh , Brandt D. Pence   +3 more
doaj   +1 more source

Enfermedad del coronavirus (covid-19) y las sirtuinas

Revista de la Facultad de Ciencias Médicas de Córdoba, 2020
Las  proteínas desacetilasas dependientes del NAD+, se denominan Sirtuinas (SIRT). Objetivos: estudiar las sirtuinas involucradas en el cáncer, así como los estudios de inhibición de SIRT1 en pacientes con la enfermedad del coronavirus COVID-19 ...
Ronald Eleazar Huarachi Olivera, Antonio Lazarte Rivera   +1 more
doaj   +1 more source

CD38 in Neurodegeneration and Neuroinflammation

Cells, 2020
Neurodegenerative diseases are characterized by neuronal degeneration as well as neuroinflammation. While CD38 is strongly expressed in brain cells including neurons, astrocytes as well as microglial cells, the role played by CD38 in neurodegeneration ...
Serge Guerreiro, Anne-Laure Privat, Laurence Bressac, Damien Toulorge   +3 more
doaj   +1 more source

Nicotinamide riboside and caffeine partially restore diminished NAD availability but not altered energy metabolism in Alzheimer's disease

Aging Cell, Volume 21, Issue 7, July 2022., 2022
Nicotinamide riboside (NR) and caffeine increase nicotinamide adenine dinucleotide (NAD), transiently modulate bioenergetic functions, and change the expression of NAD‐synthesizing, recycling, or degrading genes in dermal fibroblasts or induced pluripotent stem cell (iPSC)‐derived neural progenitors and astrocytes from late‐onset Alzheimer's disease ...
Woo‐In Ryu, Minqi Shen, Yoon Lee, Ryan A. Healy, Mariana K. Bormann, Bruce M. Cohen, Kai‐Christian Sonntag   +6 more
wiley   +1 more source

CD38 Drives Progress of Osteoarthritis by Affecting Cartilage Homeostasis

Orthopaedic Surgery, Volume 14, Issue 5, Page 946-954, May 2022., 2022
CD38 is a membrane‐bound protein. This study primarily implicates CD38 as an important regulator of chondrogenic differentiation. Inhibition of CD38 demonstrated protection against cartilage degeneration, which suggests that CD38 could be a potential therapeutic target for OA.
Jin‐jin Ma, Jun Ying, Jin‐yu Wang, Tao‐tao Xu, Han‐ting Xia, Hong‐ting Jin, Lu‐wei Xiao, Wen‐jun Shang, Wei‐qian Wang, Jian‐yin Feng   +9 more
wiley   +1 more source

The investigation of the effect of NAD, H2O2 and weak magnetic field on the antibacterial mechanism of isoniazid (INH) that first line antibiotic against M. tuberculosis agent

Medicine Science, 2020
Tuberculosis is an infectious disease, which is caused by the Mycobacterium tuberculosis complex. This disease leads to up to 1.3 million deaths out of more than eight million cases every year.
Selami Gunal, Kadir Batcioglu, Esra Erdogan   +2 more
doaj   +1 more source

CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging

Aging Cell, Volume 21, Issue 4, April 2022., 2022
The NADase CD38 plays a key role in age‐related NAD decline. The CD38 inhibitor 78c increases lifespan and healthspan of naturally aged male mice. The increase in median and maximal lifespan was about 10%. Abstract Nicotinamide adenine dinucleotide (NAD) levels decline during aging, contributing to physical and metabolic dysfunction.
Thais R. Peclat, Katie L. Thompson, Gina M. Warner, Claudia C.S. Chini, Mariana G. Tarragó, Delaram Z. Mazdeh, Chunlian Zhang, Jose Zavala‐Solorio, Ganesh Kolumam, Yao Liang Wong, Robert L. Cohen, Eduardo N. Chini   +11 more
wiley   +1 more source