Results 51 to 60 of about 18,302 (116)

Optimization of 1H‐MRS methods for large‐volume acquisition of low‐concentration downfield resonances at 3 T and 7 T

Magnetic Resonance in Medicine, Volume 93, Issue 1, Page 18-30, January 2025.
Abstract Purpose This goal of this study was to optimize spectrally selective 1H‐MRS methods for large‐volume acquisition of low‐concentration metabolites with downfield resonances at 7 T and 3 T, with particular attention paid to detection of nicotinamide adenine dinucleotide (NAD+) and tryptophan.
Neil E. Wilson, Mark A. Elliott, Ravi Prakash Reddy Nanga, Sophia Swago, Walter R. Witschey, Ravinder Reddy   +5 more
wiley   +1 more source

Effect of Dietary Ketosis and Nicotinamide Riboside on Hippocampal Krebs Cycle Intermediates and Mitochondrial Energetics in a DNA Repair‐Deficient 3xTg/POLβ+/− Alzheimer Disease Mouse Model

Journal of Neurochemistry, Volume 169, Issue 1, January 2025.
Alzheimer disease causes neurodegeneration of the hippocampus. It impedes brain glucose metabolism and impairs mitochondrial energy along electron transport chain (ETC). Will a ketone‐based diet with nicotinamide riboside restore hippocampal energy in an Alzheimer mouse model?
Robert Pawlosky, Tyler G. Demarest, M. Todd King, Darlene Estrada, Richard L. Veech, Vilhelm A. Bohr   +5 more
wiley   +1 more source

Dual treatment with kynurenine pathway inhibitors and NAD+ precursors synergistically extends life span in Drosophila

Aging Cell, Volume 23, Issue 4, April 2024.
Our study explores the impact of kynurenine pathway (KP) modulation and NAD+ supplementation on aging Drosophila. We found that KP inhibition combined with NAD+ precursors significantly enhances physical performance and extends life span. These findings suggest that targeted interventions in KP and NAD+ metabolism can synergistically improve health ...
Mariann M. Gabrawy, Reyhan Westbrook, Austin King, Nick Khosravian, Neeraj Ochaney, Tagide DeCarvalho, Qinchuan Wang, Yuqiong Yu, Qiao Huang, Adam Said, Michael Abadir, Cissy Zhang, Pratik Khare, Jennifer E. Fairman, Anne Le, Ginger L. Milne, Fernando J. Vonhoff, Jeremy D. Walston, Peter M. Abadir   +18 more
wiley   +1 more source

Metabolic control of mitophagy

European Journal of Clinical Investigation, Volume 54, Issue 4, April 2024.
Abstract Mitochondrial dysfunction is a major hallmark of ageing and related chronic disorders. Controlled removal of damaged mitochondria by the autophagic machinery, a process known as mitophagy, is vital for mitochondrial homeostasis and cell survival.
Andreas Zimmermann, Frank Madeo, Abhinav Diwan, Junichi Sadoshima, Simon Sedej, Guido Kroemer, Mahmoud Abdellatif   +6 more
wiley   +1 more source

Personalized Porous Gelatin Methacryloyl Sustained‐Release Nicotinamide Protects Against Noise‐Induced Hearing Loss

Advanced Science, Volume 11, Issue 12, March 27, 2024.
NAD+ decreases in cochlear after noise trauma, and nicotinamide supplementation boosts NAD+ and prevents neuroexcitatory in cochlear by round window administration. Personalized porous gelatin methacryloyl (PGMA) achieves long term drug release in cochlear, and nicotinamide encapsulated PGMA enhances mitochondria and synapse function, and protects ...
Baoyi Feng, Tingting Dong, Xinyu Song, Xiaofei Zheng, Chenxi Jin, Zhenzhe Cheng, Yiqing Liu, Wenjie Zhang, Xueling Wang, Yong Tao, Hao Wu   +10 more
wiley   +1 more source

Outlook of logging perspectives in the Czech Republic for the period 2013-2032

Journal of Forest Science, 2014
The aim of the submitted work was to analyze the outlook of logging perspectives in the next two decades (2013-2032) for all forests in the territory of the Czech Republic.
M. Synek, J. Vašíček, M. Zeman
doaj   +1 more source

Psychomotor activities in the context of kinanthropology: Review

Tělesná Kultura, 2015
BACKGROUND: Any scholar developing a therapeutic method shall be concerned with its historical and theoretical groundings, scientifically verifiedfacts, and information from professional publications.
Běla Hátlová, Iva Wedlichová, Milena Adámková Ségard   +2 more
doaj   +1 more source

Research Progress on Mechanism of NAD+ Metabolic Remodeling in Occurrence and Development of Glioblastoma Multiforme

Zhongliu Fangzhi Yanjiu
Gliomas, especially high-grade gliomas such as glioblastoma multiforme (GBM), are primary malignant tumors of the central nervous system, characterized by high proliferative capacity, invasiveness, and therapeutic resistance.
Jiajia CHE, Jinyuan DU, Junhao BAO, Xiting PAN, Chengwen WANG, Chuan XU, Ying SHI   +6 more
doaj   +1 more source

Identifying and categorizing influencers on Instagram with eye tracker [PDF]

Spanish Journal of Marketing-ESIC
Purpose – This paper aims to explore the recognition and success of different ways of branding native advertising in influencer marketing. Design/methodology/approach – The data are evaluated using statistical tests, correlation and cluster analysis ...
Michaela Jánská, Marta Žambochová, Zuzana Vacurová   +2 more
doaj   +1 more source

AMERICAN MULTI-DWELLING ARCHITECTURE OF THE SECOND HALF OF THE 19TH CENTURY AND FIRST HALF OF THE 20TH CENTURY [PDF]

AR: Arhitektura, Raziskave, 2013
At the end of the 19th and beginning of the 20th century, the evolution of American multiple-dwelling architecture was marked by the passage from the standard construction of single-family standalone homes and row houses to a new housing typology which ...
Srđan Nađ
doaj