Results 41 to 50 of about 365,811 (201)

EXTRACELLULAR NICOTINAMIDE ADENINE DINUCLEOTIDE (NAD) ARRESTS ENDOTHELIAL CELL PROLIFERATION

, 2022
Background: presence of NAD in the extracellular environment acts as an autocrine/paracrine signal in different cell types (including smooth myocytes, neurons, human hematopoietic stem cells, granulocytes), mediating inflammatory responses, cell ...
Christian Di Buduo, Antonella Antonelli, Alessandra Balduini, Santina Bruzzone, Francesco Piacente, Cecilia Astigiano, Michele Cea, Maria Elena Laugieri, Mauro Magnani, Andrea Benzi, Debora Soncini   +10 more
core   +1 more source

The evaluation of possibilities of sustainable tourism and recreation in the Mrtva Tisa area near Čurug7 [PDF]

Glasnik Srpskog Geografskog Društva, 2008
The preserved parts of the nature or areas that are inteded to be protected and well-planned in terms of harmonizing the nature and tourist activities and recreation could become potential eco-tourist attractions.
Nađ Imre
doaj   +1 more source

A System of Photocatalysis for NAD+ Regeneration of Product of (S)-1-Pheylethanol by Enzymic Catalysis

Bulletin of Chemical Reaction Engineering & Catalysis, 2019
In this study, a system of photocatalysis for NAD+ regeneration of enzymatic catalysis was constructed. The optimal conditions for the coupling reaction of photocatalysis and biocatalysis were explored.
Shujin Pu, Xuan Zhang, Han Huang, Chengli Yang, Dali Li, Junfang Yang, Jie Ouyang, Xing Chen, Sidra Naseer, Ruofu Shi   +9 more
doaj   +1 more source

Development of the Cerebrospinal Fluid in Early Stage after Hemorrhage in the Central Nervous System

Life, 2021
Extravasation of blood in the central nervous system (CNS) represents a very strong damaged associated molecular patterns (DAMP) which is followed by rapid inflammation and can participate in worse outcome of patients.
Petr Kelbich, Aleš Hejčl, Jan Krejsek, Tomáš Radovnický, Inka Matuchová, Jan Lodin, Jan Špička, Martin Sameš, Jan Procházka, Eva Hanuljaková, Petr Vachata   +10 more
doaj   +1 more source

Cold exposure reinstates NAD+ levels and attenuates hepatocellular carcinoma

Cell Stress
Cold exposure has been historically used for medicinal purposes, but its benefits and associated mechanisms in mammalian organisms still remain unclear.
Tatiana P Grazioso, Maria del Mar Rigual, Cristian Perna, Eduardo J Caleiras, Nabil Djouder   +4 more
doaj   +1 more source

Nicotinic Acid Restriction Enhances the Therapeutic Benefit of NAMPT Inhibition in Small‐Cell Lung Cancer Models

Cancer Science, EarlyView.
Dietary NA restriction converts the effect of NAMPT inhibition from cytostatic to cytotoxic in SCLC in vivo. ABSTRACT Small‐cell lung cancer (SCLC) is an aggressive malignancy with limited therapeutic options. We previously showed that nicotinic acid riboside (NAR) sustains NAD biosynthesis in vivo and compensates for NAMPT inhibition in SCLC models ...
Kyoji Tsurumi, Miyuki Nomura, Mai Ouchi, Shigehiro Yagishita, Naohiko Kikuchi, Taku Sato, Mami Morita, Yoji Yamashita, Kayoko Hayashi, Tomoyoshi Soga, Akinobu Hamada, Tatsuro Fukuhara, Nobuhiro Tanuma   +12 more
wiley   +1 more source

Need for NAD+: Focus on Striated Muscle Laminopathies

, 2020
International audienceLaminopathies are a heterogeneous group of rare diseases caused by genetic mutations in the LMNA gene, encoding A-type lamins. A-type lamins are nuclear envelope proteins which associate with B-type lamins to form the nuclear lamina,
Muchir, Antoine, Antoine Muchir, Cardoso, Déborah, Déborah Cardoso   +3 more
core   +1 more source

Extracellular vesicles circulating in young organisms promote healthy longevity

Journal of Extracellular Vesicles, 2019
Parabiosis experiments in mice demonstrated that a young environment could partially rejuvenate multiple tissues of old organisms. However, the circulating mediators responsible of such effect have been elusive so far.
Francesco Prattichizzo, Angelica Giuliani, Jacopo Sabbatinelli, Emanuela Mensà, Valeria De Nigris, Lucia La Sala, Paola de Candia, Fabiola Olivieri, Antonio Ceriello   +8 more
doaj   +1 more source

Structural modeling of NAD+ binding modes to PARP-1

Вавиловский журнал генетики и селекции, 2017
The nuclear protein poly (ADP-ribose) polymerase-1 (PARP-1) plays an important role in the signaling and repair of DNA. PARP-1 catalyses covalent binding of poly (ADP-ribose) polymers with itself as well as with other acceptor proteins using NAD+ as a ...
N. V. Ivanisenko, D. A. Zhechev, V. A. Ivanisenko   +2 more
doaj   +1 more source

NAD replenishment restores mitochondrial function and thermogenesis in the brown adipose tissue of mice with obesity

The Journal of Physiology, EarlyView.
Abstract figure legend A high‐fat diet (HFD) induces brown adipose tissue (BAT) whitening, mitochondrial dysfunction (damaged cristae, fragmentation), reduced NAD+ levels and impaired thermogenesis, leading to lower energy expenditure and metabolic inflexibility.
Renata R. Braga, Matheus B. Rocha, Ana P. Morelli, Raul G. da Costa, Marcelo A. S. Mori, Adelino S. R. da Silva, José R. Pauli, Dennys E. Cintra, Eduardo R. Ropelle   +8 more
wiley   +1 more source