Results 21 to 30 of about 365,811 (201)

Computational model for mammalian circadian oscillator: interacting with NAD+/SIRT1 pathway and age-related changes in gene expression of circadian oscillator

Вавиловский журнал генетики и селекции, 2017
Studies of the last decade reveal a new sight on the possible link between aging processes and circadian rhythm. New data on the role of the NAD+-dependent histone deacetylase SIRT1 in the integration of regulation pathways for circadian rhythms and ...
N. L. Podkolodnyy, N. N. Tverdokhleb, O. A. Podkolodnaya   +2 more
doaj   +1 more source

Crystal structure of a short‐chain dehydrogenase/reductase from Burkholderia phymatum in complex with NAD

Acta Crystallographica Section F, Volume 78, Issue 2, Page 52-58, February 2022., 2022
The crystal structure of a short‐chain dehydrogenase/reductase from Burkholderia phymatum offers insights into its possible functions and likely inhibitors of its enzymatic functions.Burkholderia phymatum is an important symbiotic nitrogen‐fixing betaproteobacterium. B.
Jawaher Alenazi, Stephen Mayclin, Sandhya Subramanian, Peter J. Myler, Oluwatoyin A. Asojo   +4 more
wiley   +1 more source

Endurance exercise resistance to lipotoxic cardiomyopathy is associated with cardiac NAD+/dSIR2/PGC-1α pathway activation in old Drosophila

Biology Open, 2019
Lipotoxic cardiomyopathy is caused by excessive lipid accumulation in myocardial cells and it is a form of cardiac dysfunction. Cardiac PGC-1α overexpression prevents lipotoxic cardiomyopathy induced by a high-fat diet (HFD).
Deng-Tai Wen, Lan Zheng, Jin-xiu Li, Dan Cheng, Yang Liu, Kai Lu, Wen-qi Hou   +6 more
doaj   +1 more source

Nicotinamide pathways as the root cause of sepsis – an evolutionary perspective on macrophage energetic shifts

The FEBS Journal, Volume 289, Issue 4, Page 955-964, February 2022., 2022
Increased IDO activity towards de novo nicotinamide synthesis is a hallmark of alternatively activated macrophages. IDO upregulation in alternatively activated macrophages may be an attempt to compensate for insufficient NAD availability. Manipulation of nicotinamide metabolism may shift macrophage metabolism, thereby providing a therapeutic approach ...
Melinda S. Suchard, Dana M. Savulescu
wiley   +1 more source

Nicotinamide prevention in diabetes-induced alterations in the rat liver

Endocrine Regulations, 2023
Objective. The study was performed to elucidate whether nicotinamide (NAm) can attenuate the diabetes-induced liver damage by correction of ammonia detoxifying function and disbalance of NAD-dependent processes in diabetic rats.
Kuchmerovska Tamara, Yanitska Lesya, Horkunenko Oksana, Guzyk Mykhailo, Tykhonenko Tetiana, Pryvrotska Irina   +5 more
doaj   +1 more source

Structural and catalytic characterization of Blastochloris viridis and Pseudomonas aeruginosa homospermidine synthases supports the essential role of cation–π interaction

Acta Crystallographica Section D, Volume 77, Issue 10, Page 1317-1335, October 2021., 2021
The homospermidine synthases from P. aeruginosa and B. viridis, as well as their single‐residue variants, are compared based on crystal structures and activity assays. A high structural similarity is demonstrated, suggesting the equivalent involvement of relevant residues in the reaction mechanism and catalytic dependence on cation–π interaction ...
F. Helfrich, Axel J. Scheidig
wiley   +1 more source

Augmentation of NAD+ by Dunnione Ameliorates Imiquimod-Induced Psoriasis-Like Dermatitis in Mice

Journal of Inflammation Research, 2022
Seung Hoon Lee,1,* Hyung-Jin Kim,1,* Gi-Su Oh,1 Su-Bin Lee,1 Dipendra Khadka,1 Wal Cao,1 Seong-Kyu Choe,1 Hyeok Shim,2 Chang-Deok Kim,3 Tae Hwan Kwak,4 Hong-Seob So1,4 1Department of Microbiology, Wonkwang University School of Medicine, Iksan ...
Lee SH, Kim HJ, Oh GS, Lee SB, Khadka D, Cao W, Choe SK, Shim H, Kim CD, Kwak TH, So HS   +10 more
doaj  

Hypothalamic NAD⁺-Sirtuin Axis: Function and Regulation

Biomolecules, 2020
The rapidly expanding elderly population and obesity endemic have become part of continuing global health care problems. The hypothalamus is a critical center for the homeostatic regulation of energy and glucose metabolism, circadian rhythm, and aging ...
Eun Roh, Min-Seon Kim
doaj   +1 more source

Badania nad prasą dla kobiet z okresu Polski Ludowej. Stan obecny i perspektywy [PDF]

, 2021
Celem szkicu jest przedstawienie stanu badań nad prasą dla kobiet z okresu Polski Ludowej, a od 22 lipca 1952 r. Polskiej Rzeczypospolitej Ludowej. Należało zastanowić się nad kształtującą się tradycją badawczą prasy dla kobiet z okresu PRL, stanem badań
Jędrzejski, Łukasz
core   +1 more source

Sirtuin activators as an anti-aging intervention for longevity [PDF]

Exploration of Drug Science
Sirtuins are a family of NAD+-dependent class III histone deacetylases that regulate histones and other proteins. The mammalian sirtuins comprise seven members that have a role in energy metabolism, DNA repair, inflammation, cell survival, apoptosis ...
Puja Sah, Anita K. Rai, Donkupar Syiem
doaj   +1 more source