Results 21 to 30 of about 300,505 (163)

Grabbing the genome by the NADs [PDF]

Chromosoma, 2015
The regions of the genome that interact frequently with the nucleolus have been termed nucleolar-associated domains (NADs). Deep sequencing and DNA-fluorescence in situ hybridization (FISH) experiments have revealed that these domains are enriched for repetitive elements, regions of the inactive X chromosome (Xi), and several RNA polymerase III ...
Matheson, Timothy D., Kaufman, Paul D.
openaire   +3 more sources

NAD replenishment restores mitochondrial function and thermogenesis in the brown adipose tissue of mice with obesity

The Journal of Physiology, EarlyView.
Abstract figure legend A high‐fat diet (HFD) induces brown adipose tissue (BAT) whitening, mitochondrial dysfunction (damaged cristae, fragmentation), reduced NAD+ levels and impaired thermogenesis, leading to lower energy expenditure and metabolic inflexibility.
Renata R. Braga, Matheus B. Rocha, Ana P. Morelli, Raul G. da Costa, Marcelo A. S. Mori, Adelino S. R. da Silva, José R. Pauli, Dennys E. Cintra, Eduardo R. Ropelle   +8 more
wiley   +1 more source

NAD+-dependent DNA ligases of Mycobacterium tuberculosis and Streptomyces coelicolor

, 2003
Sequencing of the genomes of Mycobacterium tuberculosis H37Rv and Streptomyces coelicolor A3(2) identified putative genes for an NAD+-dependent DNA ligase. We have cloned both open reading frames and overexpressed the protein products in Escherichia coli.
Bullard, Desmond, Smith, Andrew, Kieser, Tobias, Day, Jonathan, Sayer, Heather, Bowater, Richard, Wilkinson, Adam   +6 more
core   +1 more source

Homogeneous nucleation of NAD and NAT in liquid stratospheric aerosols: insufficient to explain denitrification

, 2002
Knopf DA, Koop T, Luo BP, Weers UG, Peter T. Homogeneous nucleation of NAD and NAT in liquid stratospheric aerosols: insufficient to explain denitrification. ATMOSPHERIC CHEMISTRY AND PHYSICS. 2002;2(3):207-214.The nucleation of NAD and NAT from HNO3/H2O
U. G. Weers, Luo, B. P., B. P. Luo, T. Peter, Weers, U. G., Koop, T., Koop, Thomas ; https://orcid.org/, Peter, T., T. Koop, Knopf, D. A., D. A. Knopf   +10 more
core   +1 more source

A combination of ketones and NAD+ precursor preserves white matter integrity in mild cognitive impairment

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 2, April/June 2026.
Abstract INTRODUCTION Brain glucose metabolism declines and myelin deteriorates as Alzheimer's disease (AD) develops. Adequate energy supply to white matter (WM) is critical to maintain myelin integrity and axonal function. An exogenous source of ketones bypasses the glucose‑specific brain energy deficit and improves cognitive outcomes in mild ...
Maggie Roy, Mélanie Fortier, Valérie St‐Pierre, Marie‐Christine Morin, Arnaud Boré, Manon Edde, Camille Vandenberghe, Karine Groulx, Étienne Croteau, Gabriel Richard, Stanislas Thoumyre, Tamas Fulop, Christian Bocti, François Rheault, Bernard Cuenoud, Maxime Descoteaux, Stephen C. Cunnane   +16 more
wiley   +1 more source

EXTRACELLULAR NICOTINAMIDE ADENINE DINUCLEOTIDE (NAD) ARRESTS ENDOTHELIAL CELL PROLIFERATION

, 2022
Background: presence of NAD in the extracellular environment acts as an autocrine/paracrine signal in different cell types (including smooth myocytes, neurons, human hematopoietic stem cells, granulocytes), mediating inflammatory responses, cell ...
Christian Di Buduo, Antonella Antonelli, Alessandra Balduini, Santina Bruzzone, Francesco Piacente, Cecilia Astigiano, Michele Cea, Maria Elena Laugieri, Mauro Magnani, Andrea Benzi, Debora Soncini   +10 more
core  

Timing of NAD Deficiency During Organogenesis Dictates Defect Type and Penetrance

The FASEB Journal, Volume 40, Issue 3, 15 February 2026.
Pregnant mice on a vitamin B3‐free and tryptophan‐limited diet have embryos with Congenital NAD Deficiency Disorder, characterized by malformations and/or death. We longitudinally tracked the maternal NAD metabolome, embryo growth, and malformation occurrence. Mice with lower NAD Salvage Pathway metabolite levels and minimal levels of derived excretion
Kayleigh Bozon, Hartmut Cuny, Nana Sunn, Ella M. M. A. Martin, Delicia Z. Sheng, Gavin Chapman, Sally L. Dunwoodie   +6 more
wiley   +1 more source

Cooperation between subcellular NAD pools in the maintenance of NAD-dependent processes [PDF]

, 2018
Nicotinamide adenine dinucleotide (NAD) is needed as a cofactor in several processes throughout the cell, and its availability is decisive for the activity of many NAD-dependent enzymes.
Tolås, Ingvill
core  

Intestinal Fut2 deficiency exacerbated alcohol‐related liver disease by disrupting nicotinamide metabolism

Clinical and Translational Medicine, Volume 15, Issue 8, August 2025.
Loss of intestinal epithelial fucosylation exacerbates alcohol‐related liver injuries. Intestinal epithelial deletion of Fut2 disrupts nicotinamide (NAM) metabolism due to the decline in bacterial nicotinamidase (PncA). Supplemented with pncA overexpressed E.coli to restore gut PncA levels can improve liver damage in alcohol‐induced intestinal ...
Liuying Chen, Zhongwei Yin, Luorui Shang, Hang Yuan, Wenkang Gao, Shuhan Wang, Shuyan Wang, Xiaohua Hou, Shenglan Yang, Huikuan Chu   +9 more
wiley   +1 more source

Maternal Circulatory NAD Precursor Levels and the Yolk Sac Determine NAD Deficiency‐Driven Congenital Malformation Risk

The FASEB Journal, Volume 39, Issue 14, 31 July 2025.
Maternal circulatory L‐tryptophan (TRP) and nicotinamide (NAM) levels are proportional to dietary TRP intake. Yolk sacs, but not embryos, perform NAD de novo synthesis. This study explores the exchange of NAD precursors between mother and conceptus, and NAD generation in conceptal tissues via the NAD de novo synthesis (blue) or salvage (red) pathways ...
Kayleigh Bozon, Hartmut Cuny, Delicia Z. Sheng, Alena Sipka, Antonia W. Shand, Natasha Nassar, Sally L. Dunwoodie   +6 more
wiley   +1 more source