Results 11 to 20 of about 365,811 (201)
Sarcopenia and Muscle Aging: A Brief Overview [PDF]
Endocrinology and Metabolism, 2020 The world is facing the new challenges of an aging population, and understanding the process of aging has therefore become one of the most important global concerns.
Tam Dao +8 more
doaj +1 more source
Special Issue | Donne e Regimi: spunti sul caso afghano [PDF]
Nuovi autoritarismi e democrazie: diritto, istituzioni, società, 2022 Redazione Rivista NAD
doaj +2 more sources
“NAD-capQ” detection and quantitation of NAD caps [PDF]
RNA, 2018 RNA 5′ cap structures comprising the metabolic effector nicotinamide adenine dinucleotide (NAD) have been identified in diverse organisms. Here we report a simple, two-step procedure to detect and quantitate NAD-capped RNA, termed “NAD-capQ.” By use of NAD-capQ we quantitate NAD-capped RNA levels in Escherichia coli, Saccharomyces cerevisiae, and human
Grudzien-Nogalska, Ewa +3 more
openaire +2 more sources
Сибирский научный медицинский журнал, 2021 The aim of the study was to assess the level of NAD+ in the brain of mice treated with beta-amyloid (Aβ), as well as to determine the activity of ADP-ribosyl cyclase/CD38 and the number of CD38-immunopositive neurons, astrocytes and endothelial cells ...
A. A. Semenova +4 more
doaj +1 more source
Nicotinamide adenine dinucleotide (NAD+). Formal potential of the NAD+/NAD· couple and NAD· dimerization rate [PDF]
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1984 The rate constant, kd, for the dimerization of the free radical (NAD), produced on the initial one-electron reduction of NAD+, was measured by double potential-step chronoamperometry, fast-scan cyclic voltammetry (cathodic-anodic peak current ratio) and slow-scan cyclic voltammetry (peak potential shift) for a medium in which neither NAD+ nor its ...
M A, Jensen, P J, Elving
openaire +2 more sources
Assays for NAD+-Dependent Reactions and NAD+ Metabolites [PDF]
, 2018 Nicotinamide adenine dinucleotide (NAD+) is an essential redox cofactor and signaling molecule that controls the activity of enzymes involved in metabolism, DNA repair, and cellular survival, such as the PARPs, CD38, and the sirtuins. Here, we describe three methods for measuring the activity of these enzymes: the etheno-NAD+ assay measures NAD ...
Michael B, Schultz +3 more
openaire +2 more sources
Aging Cell, Volume 21, Issue 7, July 2022., 2022 Nicotinamide riboside (NR) and caffeine increase nicotinamide adenine dinucleotide (NAD), transiently modulate bioenergetic functions, and change the expression of NAD‐synthesizing, recycling, or degrading genes in dermal fibroblasts or induced pluripotent stem cell (iPSC)‐derived neural progenitors and astrocytes from late‐onset Alzheimer's disease ...
Woo‐In Ryu +6 more
wiley +1 more source
Protective role of p53 in doxorubicin-induced cardiomyopathy as a mitochondrial disease
Molecular & Cellular Oncology, 2020 Doxorubicin is widely used against cancer but carries the risk of a progressive cardiomyopathy associated with mitochondrial loss. Using genetic models, our recent study demonstrates that mitochondrial genomic DNA regulation by tumor protein p53 (TP53 ...
Masahiro Nishi +2 more
doaj +1 more source
CD38 Drives Progress of Osteoarthritis by Affecting Cartilage Homeostasis
Orthopaedic Surgery, Volume 14, Issue 5, Page 946-954, May 2022., 2022 CD38 is a membrane‐bound protein. This study primarily implicates CD38 as an important regulator of chondrogenic differentiation. Inhibition of CD38 demonstrated protection against cartilage degeneration, which suggests that CD38 could be a potential therapeutic target for OA.
Jin‐jin Ma +9 more
wiley +1 more source
CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging
Aging Cell, Volume 21, Issue 4, April 2022., 2022 The NADase CD38 plays a key role in age‐related NAD decline. The CD38 inhibitor 78c increases lifespan and healthspan of naturally aged male mice. The increase in median and maximal lifespan was about 10%. Abstract Nicotinamide adenine dinucleotide (NAD) levels decline during aging, contributing to physical and metabolic dysfunction.
Thais R. Peclat +11 more
wiley +1 more source