Results 31 to 40 of about 18,302 (116)

Structural modeling of NAD+ binding modes to PARP-1

Вавиловский журнал генетики и селекции, 2017
The nuclear protein poly (ADP-ribose) polymerase-1 (PARP-1) plays an important role in the signaling and repair of DNA. PARP-1 catalyses covalent binding of poly (ADP-ribose) polymers with itself as well as with other acceptor proteins using NAD+ as a ...
N. V. Ivanisenko, D. A. Zhechev, V. A. Ivanisenko   +2 more
doaj   +1 more source

NAD replenishment restores mitochondrial function and thermogenesis in the brown adipose tissue of mice with obesity

The Journal of Physiology, EarlyView.
Abstract figure legend A high‐fat diet (HFD) induces brown adipose tissue (BAT) whitening, mitochondrial dysfunction (damaged cristae, fragmentation), reduced NAD+ levels and impaired thermogenesis, leading to lower energy expenditure and metabolic inflexibility.
Renata R. Braga, Matheus B. Rocha, Ana P. Morelli, Raul G. da Costa, Marcelo A. S. Mori, Adelino S. R. da Silva, José R. Pauli, Dennys E. Cintra, Eduardo R. Ropelle   +8 more
wiley   +1 more source

Information and Material Support to Environmental Education in Slovakia in the Times of Crisis

Acta Educationis Generalis, 2023
Introduction: The undergoing globalization brings epidemiological, economical, energetical, and environmental security risks. The current task in the field of improving the quality of the environment is educating students in schools for adaptation to the
Bilčík Alexander, Bilčíková Jana, Lajčin Daniel, Barnová Silvia   +3 more
doaj   +1 more source

Historical Agricultural Landforms—Central European Bio-Cultural Heritage Worthy of Attention

Land, 2022
Knowledge about past agricultural land management can bring solutions for future needs. One undervalued historical type of historical rural landscape in temperate Europe is termed plužiny.
Johana Zacharová, Jiří Riezner, Jitka Elznicová, Iva Machová, Karel Kubát, Diana Holcová, Michal Holec, Jan Pacina, Jiří Štojdl, Tomáš Matys Grygar   +9 more
doaj   +1 more source

The Mitochondrial NAD Transporter SLC25A51 in Adipocytes Regulates Adipose Tissue Mitochondrial Function and Systemic Metabolism During Aging

Aging Cell, Volume 25, Issue 5, May 2026.
We revealed the pathophysiological significance and therapeutic potential of adipocyte mitochondrial NAD transporter, namely solute carrier family 25 member 51 (SLC25A51), in age‐associated metabolic diseases, particularly adipose tissue mitochondrial function, obesity, and insulin resistance, by analyzing adipocyte‐specific Slc25a51 knockout (ASKO ...
Daiki Kojima, Keisuke Yaku, Shotaro Kosugi, Ryunosuke Mitsuno, Kenji Kaneko, Yoshinaga Kawano, Akihito Hishikawa, Seiya Mizuno, Manami Katoh, Akiko Satoh, Shinya Toyokuni, Tatsuhiko Azegami, Kenichiro Kinouchi, Shintaro Yamaguchi, Hiroshi Itoh, Takeshi Kanda, Toshimasa Yamauchi, Takashi Nakagawa, Kaori Hayashi, Jun Yoshino   +19 more
wiley   +1 more source

Effects of Nicotinamide Adenine Dinucleotide on Older Patients with Heart Failure

Reviews in Cardiovascular Medicine
Background: Heart failure (HF) is the main cause of death in middle-aged and older people and is characterized by high morbidity, high mortality, a high rehospitalization rate, and many high-risk groups. Nicotinamide adenine dinucleotide (NAD+) is widely
Zuowei Pei, Min Dong, Xuyang Meng, Wei Yao, Ying Guo, Fang Wang   +5 more
doaj   +1 more source

Arhitekture računala za adaptivno digitalno formiranje dijagrama usmjerenosti radarske antene

Vojnotehnički Glasnik, 1990
Kombiniranjem arhitekture sa slike 7 s principom računala upravljanog tokom podataka (data flow) (u literaturi je takva arhitektura poznata kao 'wavefront processor' ili polja valne fronte), dobivaju se dodatna poboljšanja i u smislu povećanja brzine i u
Karlo Nađ
doaj   +1 more source

Design and Synthesis of New Sulfonic Acid Functionalized Ionic Liquids as Catalysts for Esterification of Fatty Acids with Bioethanol

Molecules, 2023
In this study, three types of sulfonic acid group functionalized ionic liquids (SAILs) with a different number of catalytic groups and lipophilicity were synthesized and characterized by FT-IR, NMR, and MS analyses.
Thu Huong Nguyen Thi, Jiřina Koutecká, Pavel Kaule, Luboš Vrtoch, Václav Šícha, Jan Čermák   +5 more
doaj   +1 more source

Grabbing the genome by the NADs [PDF]

Chromosoma, 2015
The regions of the genome that interact frequently with the nucleolus have been termed nucleolar-associated domains (NADs). Deep sequencing and DNA-fluorescence in situ hybridization (FISH) experiments have revealed that these domains are enriched for repetitive elements, regions of the inactive X chromosome (Xi), and several RNA polymerase III ...
Matheson, Timothy D., Kaufman, Paul D.
openaire   +3 more sources

A combination of ketones and NAD+ precursor preserves white matter integrity in mild cognitive impairment

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 2, April/June 2026.
Abstract INTRODUCTION Brain glucose metabolism declines and myelin deteriorates as Alzheimer's disease (AD) develops. Adequate energy supply to white matter (WM) is critical to maintain myelin integrity and axonal function. An exogenous source of ketones bypasses the glucose‑specific brain energy deficit and improves cognitive outcomes in mild ...
Maggie Roy, Mélanie Fortier, Valérie St‐Pierre, Marie‐Christine Morin, Arnaud Boré, Manon Edde, Camille Vandenberghe, Karine Groulx, Étienne Croteau, Gabriel Richard, Stanislas Thoumyre, Tamas Fulop, Christian Bocti, François Rheault, Bernard Cuenoud, Maxime Descoteaux, Stephen C. Cunnane   +16 more
wiley   +1 more source