Results 11 to 20 of about 3,419 (134)

Glutaredoxin GRXS17 associates with the cytosolic iron-sulfur cluster assembly pathway [PDF]

, 2016
Cytosolic monothiol glutaredoxins (GRXs) are required in iron-sulfur (Fe-S) cluster delivery and iron sensing in yeast and mammals. In plants, it is unclear whether they have similar functions.
Cammue, Bruno PA, De Clercq, Rebecca, De Coninck, Barbara, De Jaeger, Geert, Fernie, Alisdair R, Gevaert, Kris, Goossens, Alain, Iñigo, Sabrina, Klassen, Roland, Le Gall, Sabine, Leidel, Sebastian A, Nagels Durand, Astrid, Pauwels, Laurens, Ritter Traub, Andrés, Schaffrath, Raffael, Termathe, Martin, Tohge, Takayuki, Van Leene, Jelle, Van Lijsebettens, Maria   +18 more
core   +2 more sources

Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase [PDF]

, 2010
Background Inhibitors of nicotinamide phosphoribosyltransferase (NAMPT) are promising cancer drugs currently in clinical trials in oncology, including APO866, CHS-828 and the CHS-828 prodrug EB1627/GMX1777, but cancer cell resistance to these drugs has ...
A Formentini, A Garten, A Nahimana, A Ravaud, AA Sauve, Annemette V Thougaard, Antje Garten, C Lengauer, C Mattos, C Schou, F Nomura, Fredrik Björkling, G Kroemer, GB Kang, GC Elliott, GJ Hageman, GJ Peters, J Diefenbach, J Gullbo, JA Khan, JA Khan, Jakob G Petersen, JB Clark, JR Revollo, JR Revollo, JR Revollo, Jun Yoshino, K Holen, LR Saunders, LS Olsen, M Hasmann, M Pishvaian, M Watson, M Ziegler, Maxwell Sehested, MD Jackson, ME Gorre, ME Gorre, Mette K Christensen, MK Kim, P Hovstadius, P Hovstadius, P Martinsson, PA Janne, PB Jensen, Peter B Jensen, Peter Fristrup, PJ Hjarnaa, SB Hassan, Shin-Ichiro Imai, Søren J Nielsen, T O'Hare, T Wang, U Galli, Uffe H Olesen, UH Olesen, UH Olesen, Wieland Kiess   +57 more
core   +5 more sources

NAD(P) hydrolyzing enzymes in skipjack liver. II. Physico-chemical and enzymatic properties of NAD (P) nucleosidase.

NIPPON SUISAN GAKKAISHI, 1977
The physico-chomical and enzymatic properties of NAD (P) nucelsidase from skipjack liver was examined using a partially purified and two purified specimens (Frs. I and II). The molecular weights of Fr. I and II enzymes were estimated to be 30, 000 and 20, 000 and the isoelectric points to be 3.5 and 4.3, respectively. On SDS-electeophoresis, the Fr. II
Hiroki ABE, Chiaki SHIMIZU, Fumio MATSUURA   +2 more
openaire   +2 more sources

Ureide biogenesis and the enzymes of ammonia assimilation and ureide biosynthesis in nitrogen fixing pigeonpea (Cajanus cajan) nodules [PDF]

, 1984
Allantoic acid production from IMP, XMP, inosine, xanthosine, hypoxanthine, xanthine, uric acid and allantoin was investigated by incubating each of these substrates withCajanus cajan cytosol and bacteroid fractions separately in the presence and absence
Amarjit,, Singh, Randhir
core   +1 more source

Biocatalytic Alkylation of Ambident Nucleophiles Enables Selective N‐Functionalization of Heterocycles and Late‐Stage Modifications

Angewandte Chemie, Volume 137, Issue 36, September 1, 2025.
N‐alkylated heteroarenes are key structural motifs in bioactive compounds, but their regioselective synthesis via coupling of readily available azoles with haloalkanes remains very challenging. Here, we present a mild biocatalytic approach that proceeds on gram‐scale, is highly chemo‐ and regioselective, offering rapid access to valuable N‐alkylated ...
Felipe Ospina, Kai H. Schülke, Marius Schnutenhaus, Alina Klein, Om Desai, Shubhanshu Jain, Christine Krofta, Lukas Stratmann, Jianing Yang, Harald Gröger, Stephan C. Hammer   +10 more
wiley   +2 more sources

Functional Disorders of the Brain Induced by Synthesis of Nucleotides Containing 3-Acetylpyridine [PDF]

, 1968
Peer ...
HERKEN, H.
core   +1 more source

Enzymes of ammonia assimilation and ureide biogenesis in developing pigeonpea (Cajanus cajan L.) nodules [PDF]

, 1985
Ammonia assimilatory and ureide biogenic enzymes were measured in the cytosol fraction of pigeonpea nodules during the period 15-120 days after sowing. The activity of enzymes involved in the initial assimilation of ammonia, i.e.
Amarjit,, Singh, Randhir
core   +1 more source

Evidence for quorum sensing and differential metabolite production by a marine bacterium in response to DMSP [PDF]

, 2016
© The Author(s), 2016. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in The ISME Journal 10 (2016): 2304–2316, doi:10.1038/ismej.2016.6.Microbes, the foundation of the marine
Johnson, Winifred M., Kido Soule, Melissa C., Kujawinski, Elizabeth B.   +2 more
core   +1 more source

Isoniazid-resistant mutants of Mycobacterium tuberculosis H 37 RV: uptake of isoniazid and the properties of NADase inhibitor [PDF]

, 1970
Six independent isoniazid-resistant mutants of Mycobacterium tuberculosis were isolated under conditions which largely ensured the selection of one-step mutants.
Ramakrishnan, T., Sriprakash, K. S.
core   +1 more source

Characterisation of the N‐Methyltransferase SgPsmC: Application in the Kinetic Resolution of Pyrroloindolines

Angewandte Chemie International Edition, Volume 65, Issue 2, 9 January 2026.
The N‐methyltransferase SgPsmC was characterised and applied in the kinetic resolution (KR) of easily obtainable pyrroloindolines. Substitution at 3a‐position proved to be a principal determinant for the enzyme's enantioselectivity. While moving toward laboratory scale, the reaction was coupled with a methionine adenosyl transferase for in situ ...
Benjamin Panagiotis Chapple, Lia Nitz, Pascal Schneider, Birgit Henßen, Sebastian Myllek, Mona Haase, Thomas Classen, Jörg Pietruszka   +7 more
wiley   +1 more source