Results 21 to 30 of about 999,429 (336)

Enfermedad del coronavirus (covid-19) y las sirtuinas

Revista de la Facultad de Ciencias Médicas de Córdoba, 2020
Las  proteínas desacetilasas dependientes del NAD+, se denominan Sirtuinas (SIRT). Objetivos: estudiar las sirtuinas involucradas en el cáncer, así como los estudios de inhibición de SIRT1 en pacientes con la enfermedad del coronavirus COVID-19 ...
Ronald Eleazar Huarachi Olivera, Antonio Lazarte Rivera   +1 more
doaj   +1 more source

Nicotinamide riboside and caffeine partially restore diminished NAD availability but not altered energy metabolism in Alzheimer's disease

Aging Cell, Volume 21, Issue 7, July 2022., 2022
Nicotinamide riboside (NR) and caffeine increase nicotinamide adenine dinucleotide (NAD), transiently modulate bioenergetic functions, and change the expression of NAD‐synthesizing, recycling, or degrading genes in dermal fibroblasts or induced pluripotent stem cell (iPSC)‐derived neural progenitors and astrocytes from late‐onset Alzheimer's disease ...
Woo‐In Ryu, Minqi Shen, Yoon Lee, Ryan A. Healy, Mariana K. Bormann, Bruce M. Cohen, Kai‐Christian Sonntag   +6 more
wiley   +1 more source

CD38 Drives Progress of Osteoarthritis by Affecting Cartilage Homeostasis

Orthopaedic Surgery, Volume 14, Issue 5, Page 946-954, May 2022., 2022
CD38 is a membrane‐bound protein. This study primarily implicates CD38 as an important regulator of chondrogenic differentiation. Inhibition of CD38 demonstrated protection against cartilage degeneration, which suggests that CD38 could be a potential therapeutic target for OA.
Jin‐jin Ma, Jun Ying, Jin‐yu Wang, Tao‐tao Xu, Han‐ting Xia, Hong‐ting Jin, Lu‐wei Xiao, Wen‐jun Shang, Wei‐qian Wang, Jian‐yin Feng   +9 more
wiley   +1 more source

CD38 in Neurodegeneration and Neuroinflammation

Cells, 2020
Neurodegenerative diseases are characterized by neuronal degeneration as well as neuroinflammation. While CD38 is strongly expressed in brain cells including neurons, astrocytes as well as microglial cells, the role played by CD38 in neurodegeneration ...
Serge Guerreiro, Anne-Laure Privat, Laurence Bressac, Damien Toulorge   +3 more
doaj   +1 more source

CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging

Aging Cell, Volume 21, Issue 4, April 2022., 2022
The NADase CD38 plays a key role in age‐related NAD decline. The CD38 inhibitor 78c increases lifespan and healthspan of naturally aged male mice. The increase in median and maximal lifespan was about 10%. Abstract Nicotinamide adenine dinucleotide (NAD) levels decline during aging, contributing to physical and metabolic dysfunction.
Thais R. Peclat, Katie L. Thompson, Gina M. Warner, Claudia C.S. Chini, Mariana G. Tarragó, Delaram Z. Mazdeh, Chunlian Zhang, Jose Zavala‐Solorio, Ganesh Kolumam, Yao Liang Wong, Robert L. Cohen, Eduardo N. Chini   +11 more
wiley   +1 more source

Crystal structure of a short‐chain dehydrogenase/reductase from Burkholderia phymatum in complex with NAD

Acta Crystallographica Section F, Volume 78, Issue 2, Page 52-58, February 2022., 2022
The crystal structure of a short‐chain dehydrogenase/reductase from Burkholderia phymatum offers insights into its possible functions and likely inhibitors of its enzymatic functions.Burkholderia phymatum is an important symbiotic nitrogen‐fixing betaproteobacterium. B.
Jawaher Alenazi, Stephen Mayclin, Sandhya Subramanian, Peter J. Myler, Oluwatoyin A. Asojo   +4 more
wiley   +1 more source

The investigation of the effect of NAD, H2O2 and weak magnetic field on the antibacterial mechanism of isoniazid (INH) that first line antibiotic against M. tuberculosis agent

Medicine Science, 2020
Tuberculosis is an infectious disease, which is caused by the Mycobacterium tuberculosis complex. This disease leads to up to 1.3 million deaths out of more than eight million cases every year.
Selami Gunal, Kadir Batcioglu, Esra Erdogan   +2 more
doaj   +1 more source

Nicotinamide pathways as the root cause of sepsis – an evolutionary perspective on macrophage energetic shifts

The FEBS Journal, Volume 289, Issue 4, Page 955-964, February 2022., 2022
Increased IDO activity towards de novo nicotinamide synthesis is a hallmark of alternatively activated macrophages. IDO upregulation in alternatively activated macrophages may be an attempt to compensate for insufficient NAD availability. Manipulation of nicotinamide metabolism may shift macrophage metabolism, thereby providing a therapeutic approach ...
Melinda S. Suchard, Dana M. Savulescu
wiley   +1 more source

Historical Agricultural Landforms—Central European Bio-Cultural Heritage Worthy of Attention

Land, 2022
Knowledge about past agricultural land management can bring solutions for future needs. One undervalued historical type of historical rural landscape in temperate Europe is termed plužiny.
Johana Zacharová, Jiří Riezner, Jitka Elznicová, Iva Machová, Karel Kubát, Diana Holcová, Michal Holec, Jan Pacina, Jiří Štojdl, Tomáš Matys Grygar   +9 more
doaj   +1 more source

Structural and catalytic characterization of Blastochloris viridis and Pseudomonas aeruginosa homospermidine synthases supports the essential role of cation–π interaction

Acta Crystallographica Section D, Volume 77, Issue 10, Page 1317-1335, October 2021., 2021
The homospermidine synthases from P. aeruginosa and B. viridis, as well as their single‐residue variants, are compared based on crystal structures and activity assays. A high structural similarity is demonstrated, suggesting the equivalent involvement of relevant residues in the reaction mechanism and catalytic dependence on cation–π interaction ...
F. Helfrich, Axel J. Scheidig
wiley   +1 more source