Results 21 to 30 of about 299,285 (291)
NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential
Signal Transduction and Targeted Therapy, 2020 Nicotinamide adenine dinucleotide (NAD + ) and its metabolites function as critical regulators to maintain physiologic processes, enabling the plastic cells to adapt to environmental changes including nutrient perturbation, genotoxic factors, circadian ...
N. Xie +8 more
semanticscholar +1 more source
Acta Crystallographica Section D, Volume 77, Issue 10, Page 1317-1335, October 2021., 2021 The homospermidine synthases from P. aeruginosa and B. viridis, as well as their single‐residue variants, are compared based on crystal structures and activity assays. A high structural similarity is demonstrated, suggesting the equivalent involvement of relevant residues in the reaction mechanism and catalytic dependence on cation–π interaction ...
F. Helfrich, Axel J. Scheidig
wiley +1 more source
Journal of Cellular and Molecular Medicine, Volume 25, Issue 13, Page 5884-5898, July 2021., 2021 Abstract Nicotinamide adenine dinucleotide (NAD+) is crucial for cell energy metabolism and many signalling processes. Recently, we proved the role of ecto‐enzymes in controlling adenine nucleotide–dependent pathways during calcific aortic valve disease (CAVD).
Patrycja Jablonska +9 more
wiley +1 more source
Assays for NAD+-Dependent Reactions and NAD+ Metabolites [PDF]
, 2018 Nicotinamide adenine dinucleotide (NAD+) is an essential redox cofactor and signaling molecule that controls the activity of enzymes involved in metabolism, DNA repair, and cellular survival, such as the PARPs, CD38, and the sirtuins. Here, we describe three methods for measuring the activity of these enzymes: the etheno-NAD+ assay measures NAD ...
David A. Sinclair +4 more
openaire +2 more sources
Grabbing the genome by the NADs [PDF]
Chromosoma, 2015 The regions of the genome that interact frequently with the nucleolus have been termed nucleolar-associated domains (NADs). Deep sequencing and DNA-fluorescence in situ hybridization (FISH) experiments have revealed that these domains are enriched for repetitive elements, regions of the inactive X chromosome (Xi), and several RNA polymerase III ...
Matheson, Timothy D., Kaufman, Paul D.
openaire +4 more sources
Increased demand for NAD+ relative to ATP drives aerobic glycolysis
bioRxiv, 2020 Aerobic glycolysis, or preferential fermentation of glucose-derived pyruvate to lactate despite available oxygen, is a hallmark of proliferative metabolism that is observed across many organisms and conditions. To better understand why aerobic glycolysis
Alba Luengo +13 more
semanticscholar +1 more source
Molecules, 2023 In this study, three types of sulfonic acid group functionalized ionic liquids (SAILs) with a different number of catalytic groups and lipophilicity were synthesized and characterized by FT-IR, NMR, and MS analyses.
Thu Huong Nguyen Thi +5 more
doaj +1 more source
The essential schistosome tegumental ectoenzyme SmNPP5 can block NAD-induced T cell apoptosis
Virulence, 2020 Infection with intravascular platyhelminths of the genus Schistosoma can result in the debilitating disease schistosomiasis. Schistosomes (blood flukes) can survive in the host for many years.
Catherine S. Nation +2 more
doaj +1 more source
mBio, 2023 ABSTRACT Nicotinamide adenine dinucleotide (NAD) and its phosphorylated derivative (NADP) are essential cofactors that participate in hundreds of biochemical reactions and have emerged as therapeutic targets in cancer, metabolic disorders, neurodegenerative diseases, and infections, including tuberculosis.
Ritu Sharma +11 more
openaire +3 more sources
NAD(P)H oxidase: role in cardiovascular biology and disease.
Circulation Research, 2000 Reactive oxygen species have emerged as important molecules in cardiovascular function. Recent work has shown that NAD(P)H oxidases are major sources of superoxide in vascular cells and myocytes.
K. Griendling +2 more
semanticscholar +1 more source