Results 21 to 30 of about 205,573 (216)

Nicotinamide riboside and caffeine partially restore diminished NAD availability but not altered energy metabolism in Alzheimer's disease

Aging Cell, Volume 21, Issue 7, July 2022., 2022
Nicotinamide riboside (NR) and caffeine increase nicotinamide adenine dinucleotide (NAD), transiently modulate bioenergetic functions, and change the expression of NAD‐synthesizing, recycling, or degrading genes in dermal fibroblasts or induced pluripotent stem cell (iPSC)‐derived neural progenitors and astrocytes from late‐onset Alzheimer's disease ...
Woo‐In Ryu, Minqi Shen, Yoon Lee, Ryan A. Healy, Mariana K. Bormann, Bruce M. Cohen, Kai‐Christian Sonntag   +6 more
wiley   +1 more source

The investigation of the effect of NAD, H2O2 and weak magnetic field on the antibacterial mechanism of isoniazid (INH) that first line antibiotic against M. tuberculosis agent

Medicine Science, 2020
Tuberculosis is an infectious disease, which is caused by the Mycobacterium tuberculosis complex. This disease leads to up to 1.3 million deaths out of more than eight million cases every year.
Selami Gunal, Kadir Batcioglu, Esra Erdogan   +2 more
doaj   +1 more source

CD38 Drives Progress of Osteoarthritis by Affecting Cartilage Homeostasis

Orthopaedic Surgery, Volume 14, Issue 5, Page 946-954, May 2022., 2022
CD38 is a membrane‐bound protein. This study primarily implicates CD38 as an important regulator of chondrogenic differentiation. Inhibition of CD38 demonstrated protection against cartilage degeneration, which suggests that CD38 could be a potential therapeutic target for OA.
Jin‐jin Ma, Jun Ying, Jin‐yu Wang, Tao‐tao Xu, Han‐ting Xia, Hong‐ting Jin, Lu‐wei Xiao, Wen‐jun Shang, Wei‐qian Wang, Jian‐yin Feng   +9 more
wiley   +1 more source

CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging

Aging Cell, Volume 21, Issue 4, April 2022., 2022
The NADase CD38 plays a key role in age‐related NAD decline. The CD38 inhibitor 78c increases lifespan and healthspan of naturally aged male mice. The increase in median and maximal lifespan was about 10%. Abstract Nicotinamide adenine dinucleotide (NAD) levels decline during aging, contributing to physical and metabolic dysfunction.
Thais R. Peclat, Katie L. Thompson, Gina M. Warner, Claudia C.S. Chini, Mariana G. Tarragó, Delaram Z. Mazdeh, Chunlian Zhang, Jose Zavala‐Solorio, Ganesh Kolumam, Yao Liang Wong, Robert L. Cohen, Eduardo N. Chini   +11 more
wiley   +1 more source

Investigation of sand in piping [PDF]

Zbornik Matice Srpske za Prirodne Nauke, 2012
For the investigation of the grain size distribution of the material washed out from the piping, we used 20 samples originating from different places on the Danube and the Tisza rivers.
Nađ Laslo
doaj   +1 more source

Crystal structure of a short‐chain dehydrogenase/reductase from Burkholderia phymatum in complex with NAD

Acta Crystallographica Section F, Volume 78, Issue 2, Page 52-58, February 2022., 2022
The crystal structure of a short‐chain dehydrogenase/reductase from Burkholderia phymatum offers insights into its possible functions and likely inhibitors of its enzymatic functions.Burkholderia phymatum is an important symbiotic nitrogen‐fixing betaproteobacterium. B.
Jawaher Alenazi, Stephen Mayclin, Sandhya Subramanian, Peter J. Myler, Oluwatoyin A. Asojo   +4 more
wiley   +1 more source

Assays for NAD+-Dependent Reactions and NAD+ Metabolites [PDF]

, 2018
Nicotinamide adenine dinucleotide (NAD+) is an essential redox cofactor and signaling molecule that controls the activity of enzymes involved in metabolism, DNA repair, and cellular survival, such as the PARPs, CD38, and the sirtuins. Here, we describe three methods for measuring the activity of these enzymes: the etheno-NAD+ assay measures NAD ...
David A. Sinclair, David A. Sinclair, Nady Braidy, Michael B. Schultz, Yuancheng Lu   +4 more
openaire   +2 more sources

Nicotinamide pathways as the root cause of sepsis – an evolutionary perspective on macrophage energetic shifts

The FEBS Journal, Volume 289, Issue 4, Page 955-964, February 2022., 2022
Increased IDO activity towards de novo nicotinamide synthesis is a hallmark of alternatively activated macrophages. IDO upregulation in alternatively activated macrophages may be an attempt to compensate for insufficient NAD availability. Manipulation of nicotinamide metabolism may shift macrophage metabolism, thereby providing a therapeutic approach ...
Melinda S. Suchard, Dana M. Savulescu
wiley   +1 more source

Characterization of sand boils with grading entropy [PDF]

Zbornik Matice Srpske za Prirodne Nauke, 2012
Grain size and grain distribution by size are dominant factors determining soil behaviour. The shape and position of a grain distribution curve contain implicit information about the propensity of sand boiling or piping at flood conditions. The author
Nađ Laslo
doaj   +1 more source

Structural and catalytic characterization of Blastochloris viridis and Pseudomonas aeruginosa homospermidine synthases supports the essential role of cation–π interaction

Acta Crystallographica Section D, Volume 77, Issue 10, Page 1317-1335, October 2021., 2021
The homospermidine synthases from P. aeruginosa and B. viridis, as well as their single‐residue variants, are compared based on crystal structures and activity assays. A high structural similarity is demonstrated, suggesting the equivalent involvement of relevant residues in the reaction mechanism and catalytic dependence on cation–π interaction ...
F. Helfrich, Axel J. Scheidig
wiley   +1 more source