The essential schistosome tegumental ectoenzyme SmNPP5 can block NAD-induced T cell apoptosis
Virulence, 2020 Infection with intravascular platyhelminths of the genus Schistosoma can result in the debilitating disease schistosomiasis. Schistosomes (blood flukes) can survive in the host for many years.
Catherine S. Nation +2 more
doaj +1 more source
Increased demand for NAD+ relative to ATP drives aerobic glycolysis
bioRxiv, 2020 Aerobic glycolysis, or preferential fermentation of glucose-derived pyruvate to lactate despite available oxygen, is a hallmark of proliferative metabolism that is observed across many organisms and conditions. To better understand why aerobic glycolysis
Alba Luengo +13 more
semanticscholar +1 more source
Journal of Neuroinflammation, 2021 Microglial-mediated neuroinflammation plays an important role in vascular dementia, and modulating neuroinflammation has emerged as a promising treatment target. Nicotinamide adenine dinucleotide (NAD+) shows anti-inflammatory and anti-oxidant effects in
Yao Zhao +9 more
semanticscholar +1 more source
Sirtuins in the pathogenetic therapy of neurodegenerative diseases [PDF]
Клиническая практикаThe progressive decline in the physiological functions during aging leads to various diseases that place a heavy burden on patients, their families and the society as a whole.
Ekaterina M. Samoilova +4 more
doaj +1 more source
NAD+ homeostasis in human health and disease
EMBO Molecular Medicine, 2021 Depletion of nicotinamide adenine dinucleotide (NAD+), a central redox cofactor and the substrate of key metabolic enzymes, is the causative factor of a number of inherited and acquired diseases in humans. Primary deficiencies of NAD+ homeostasis are the
R. Zapata-Pérez +3 more
semanticscholar +1 more source
The evaluation of possibilities of sustainable tourism and recreation in the Mrtva Tisa area near Čurug7 [PDF]
Glasnik Srpskog Geografskog Društva, 2008 The preserved parts of the nature or areas that are inteded to be protected and well-planned in terms of harmonizing the nature and tourist activities and recreation could become potential eco-tourist attractions.
Nađ Imre
doaj +1 more source
It takes two to tango: NAD+ and sirtuins in aging/longevity control [PDF]
, 2016 The coupling of nicotinamide adenine dinucleotide (NAD+) breakdown and protein deacylation is a unique feature of the family of proteins called ‘sirtuins.’ This intimate connection between NAD+ and sirtuins has an ancient origin and provides a ...
Guarente, Leonard, Imai, Shin-ichiro
core +2 more sources
Quantitation of intracellular NAD(P)H can monitor an imbalance of DNA single strand break repair in base excision repair deficient cells in real time [PDF]
, 2003 DNA single strand breaks (SSBs) are one of the most frequent DNA lesions in genomic DNA generated either by oxidative stress or during the base excision repair pathways.
Asakura, Shoji +5 more
core +3 more sources
CD38, CD157, and RAGE as Molecular Determinants for Social Behavior
Cells, 2019 Recent studies provide evidence to support that cluster of differentiation 38 (CD38) and CD157 meaningfully act in the brain as neuroregulators. They primarily affect social behaviors. Social behaviors are impaired in Cd38 and Cd157 knockout mice. Single-
Haruhiro Higashida +22 more
doaj +1 more source
Development of the Cerebrospinal Fluid in Early Stage after Hemorrhage in the Central Nervous System
Life, 2021 Extravasation of blood in the central nervous system (CNS) represents a very strong damaged associated molecular patterns (DAMP) which is followed by rapid inflammation and can participate in worse outcome of patients.
Petr Kelbich +10 more
doaj +1 more source