Results 21 to 30 of about 213,525 (212)

CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging

Aging Cell, Volume 21, Issue 4, April 2022., 2022
The NADase CD38 plays a key role in age‐related NAD decline. The CD38 inhibitor 78c increases lifespan and healthspan of naturally aged male mice. The increase in median and maximal lifespan was about 10%. Abstract Nicotinamide adenine dinucleotide (NAD) levels decline during aging, contributing to physical and metabolic dysfunction.
Thais R. Peclat, Katie L. Thompson, Gina M. Warner, Claudia C.S. Chini, Mariana G. Tarragó, Delaram Z. Mazdeh, Chunlian Zhang, Jose Zavala‐Solorio, Ganesh Kolumam, Yao Liang Wong, Robert L. Cohen, Eduardo N. Chini   +11 more
wiley   +1 more source

Crystal structure of a short‐chain dehydrogenase/reductase from Burkholderia phymatum in complex with NAD

Acta Crystallographica Section F, Volume 78, Issue 2, Page 52-58, February 2022., 2022
The crystal structure of a short‐chain dehydrogenase/reductase from Burkholderia phymatum offers insights into its possible functions and likely inhibitors of its enzymatic functions.Burkholderia phymatum is an important symbiotic nitrogen‐fixing betaproteobacterium. B.
Jawaher Alenazi, Stephen Mayclin, Sandhya Subramanian, Peter J. Myler, Oluwatoyin A. Asojo   +4 more
wiley   +1 more source

Nicotinamide pathways as the root cause of sepsis – an evolutionary perspective on macrophage energetic shifts

The FEBS Journal, Volume 289, Issue 4, Page 955-964, February 2022., 2022
Increased IDO activity towards de novo nicotinamide synthesis is a hallmark of alternatively activated macrophages. IDO upregulation in alternatively activated macrophages may be an attempt to compensate for insufficient NAD availability. Manipulation of nicotinamide metabolism may shift macrophage metabolism, thereby providing a therapeutic approach ...
Melinda S. Suchard, Dana M. Savulescu
wiley   +1 more source

Structural and catalytic characterization of Blastochloris viridis and Pseudomonas aeruginosa homospermidine synthases supports the essential role of cation–π interaction

Acta Crystallographica Section D, Volume 77, Issue 10, Page 1317-1335, October 2021., 2021
The homospermidine synthases from P. aeruginosa and B. viridis, as well as their single‐residue variants, are compared based on crystal structures and activity assays. A high structural similarity is demonstrated, suggesting the equivalent involvement of relevant residues in the reaction mechanism and catalytic dependence on cation–π interaction ...
F. Helfrich, Axel J. Scheidig
wiley   +1 more source

Characterization of sand boils with grading entropy [PDF]

Zbornik Matice Srpske za Prirodne Nauke, 2012
Grain size and grain distribution by size are dominant factors determining soil behaviour. The shape and position of a grain distribution curve contain implicit information about the propensity of sand boiling or piping at flood conditions. The author
Nađ Laslo
doaj   +1 more source

NAD+ surfaces again [PDF]

Biochemical Journal, 2004
NAD+ and its metabolites serve important functions in intracellular signalling. NAD+-mediated regulatory processes also take place on the cell surface, particularly of immune cells. In this issue of the Biochemical Journal, Gerth et al. have demonstrated a new mechanism of Ca2+ uptake into monocytes which is triggered by NAD+ or its degradation product,
Mathias, Ziegler, Marc, Niere
openaire   +2 more sources

The new insight into extracellular NAD+ degradation‐the contribution of CD38 and CD73 in calcific aortic valve disease

Journal of Cellular and Molecular Medicine, Volume 25, Issue 13, Page 5884-5898, July 2021., 2021
Abstract Nicotinamide adenine dinucleotide (NAD+) is crucial for cell energy metabolism and many signalling processes. Recently, we proved the role of ecto‐enzymes in controlling adenine nucleotide–dependent pathways during calcific aortic valve disease (CAVD).
Patrycja Jablonska, Barbara Kutryb‐Zajac, Paulina Mierzejewska, Agnieszka Jasztal, Barbara Bocian, Romuald Lango, Jan Rogowski, Stefan Chlopicki, Ryszard T. Smolenski, Ewa M. Slominska   +9 more
wiley   +1 more source

The essential schistosome tegumental ectoenzyme SmNPP5 can block NAD-induced T cell apoptosis

Virulence, 2020
Infection with intravascular platyhelminths of the genus Schistosoma can result in the debilitating disease schistosomiasis. Schistosomes (blood flukes) can survive in the host for many years.
Catherine S. Nation, Akram A. Da’Dara, Patrick J. Skelly   +2 more
doaj   +1 more source

Nicotinamide adenine dinucleotide (NAD+). Formal potential of the NAD+/NAD· couple and NAD· dimerization rate [PDF]

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1984
The rate constant, kd, for the dimerization of the free radical (NAD), produced on the initial one-electron reduction of NAD+, was measured by double potential-step chronoamperometry, fast-scan cyclic voltammetry (cathodic-anodic peak current ratio) and slow-scan cyclic voltammetry (peak potential shift) for a medium in which neither NAD+ nor its ...
M A, Jensen, P J, Elving
openaire   +2 more sources

Sirtuins in the pathogenetic therapy of neurodegenerative diseases [PDF]

Клиническая практика
The progressive decline in the physiological functions during aging leads to various diseases that place a heavy burden on patients, their families and the society as a whole.
Ekaterina M. Samoilova, Alina A. Ivanova, Petr P. Laktionov, Vladimir A. Kalsin, Stanislav E. Romanov   +4 more
doaj   +1 more source