Results 21 to 30 of about 968,543 (216)

Quantitation of intracellular NAD(P)H can monitor an imbalance of DNA single strand break repair in base excision repair deficient cells in real time [PDF]

, 2003
DNA single strand breaks (SSBs) are one of the most frequent DNA lesions in genomic DNA generated either by oxidative stress or during the base excision repair pathways.
Asakura, Shoji, Caldecott, Keith W, de Murcia, Gilbert, Hester, Susan D, Nakamura, Jun, Swenberg, James A   +5 more
core   +3 more sources

CD38, CD157, and RAGE as Molecular Determinants for Social Behavior

Cells, 2019
Recent studies provide evidence to support that cluster of differentiation 38 (CD38) and CD157 meaningfully act in the brain as neuroregulators. They primarily affect social behaviors. Social behaviors are impaired in Cd38 and Cd157 knockout mice. Single-
Haruhiro Higashida, Minako Hashii, Yukie Tanaka, Shigeru Matsukawa, Yoshihiro Higuchi, Ryosuke Gabata, Makoto Tsubomoto, Noriko Seishima, Mitsuyo Teramachi, Taiki Kamijima, Tsuyoshi Hattori, Osamu Hori, Chiharu Tsuji, Stanislav M. Cherepanov, Anna A. Shabalova, Maria Gerasimenko, Kana Minami, Shigeru Yokoyama, Sei-ichi Munesue, Ai Harashima, Yasuhiko Yamamoto, Alla B. Salmina, Olga Lopatina   +22 more
doaj   +1 more source

Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53 independent pathways [PDF]

, 2014
Most cancer cells use aerobic glycolysis to fuel their growth. The enzyme lactate dehydrogenase-A (LDH-A) is key to cancer’s glycolytic phenotype, catalysing the regeneration of nicotinamide adenine dinucleotide (NAD þ ) from reduced nicotinamide adenine
Allison, Simon J., Granchi, C., Knight, J.R.P., Milner, J., Minutolo, F., Phillips, R.M., Rani, R.   +6 more
core   +1 more source

Historical Agricultural Landforms—Central European Bio-Cultural Heritage Worthy of Attention

Land, 2022
Knowledge about past agricultural land management can bring solutions for future needs. One undervalued historical type of historical rural landscape in temperate Europe is termed plužiny.
Johana Zacharová, Jiří Riezner, Jitka Elznicová, Iva Machová, Karel Kubát, Diana Holcová, Michal Holec, Jan Pacina, Jiří Štojdl, Tomáš Matys Grygar   +9 more
doaj   +1 more source

Can adenine nucleotides predict primary nonfunction of the human liver homograft? [PDF]

, 1994
Sixty-eight primary liver grafts were analyzed to see whether adenine nucleotides (AN: ATP, ADP, and AMP) or purine catabolites (PC: adenosine, inosine, hypoxanthine, and xanthine) of tissue or effluent can predict primary graft nonfunction.
Bronsther, O, Fujita, S, Hamamoto, I, Irish, W, Nakamura, K, Starzl, TE, Takaya, S, Todo, S, Van Gulik, TM   +8 more
core   +1 more source

Arhitekture računala za adaptivno digitalno formiranje dijagrama usmjerenosti radarske antene

Vojnotehnički Glasnik, 1990
Kombiniranjem arhitekture sa slike 7 s principom računala upravljanog tokom podataka (data flow) (u literaturi je takva arhitektura poznata kao 'wavefront processor' ili polja valne fronte), dobivaju se dodatna poboljšanja i u smislu povećanja brzine i u
Karlo Nađ
doaj   +1 more source

Murine iNKT cells are depleted by liver damage via activation of P2RX7

European Journal of Immunology, Volume 50, Issue 10, Page 1515-1524, October 2020., 2020
Drug‐induced liver injury activates a suicide pathway in hepatic iNKT cells. The tissue damage induced release of ATP and NAD into the extracellular space triggers the receptor P2RX7 and leads locally to a long‐lasting depletion of iNKT cells. Abstract Invariant natural killer T cells (iNKT) constitute up to 50% of liver lymphocytes and contribute to ...
Astrid A. Bovens, Thomas H. Wesselink, Felix M. Behr, Natasja A. M. Kragten, René A. W. van Lier, Klaas P. J. M. van Gisbergen, Regina Stark   +6 more
wiley   +1 more source

Information and Material Support to Environmental Education in Slovakia in the Times of Crisis

Acta Educationis Generalis, 2023
Introduction: The undergoing globalization brings epidemiological, economical, energetical, and environmental security risks. The current task in the field of improving the quality of the environment is educating students in schools for adaptation to the
Bilčík Alexander, Bilčíková Jana, Lajčin Daniel, Barnová Silvia   +3 more
doaj   +1 more source

Design and Synthesis of New Sulfonic Acid Functionalized Ionic Liquids as Catalysts for Esterification of Fatty Acids with Bioethanol

Molecules, 2023
In this study, three types of sulfonic acid group functionalized ionic liquids (SAILs) with a different number of catalytic groups and lipophilicity were synthesized and characterized by FT-IR, NMR, and MS analyses.
Thu Huong Nguyen Thi, Jiřina Koutecká, Pavel Kaule, Luboš Vrtoch, Václav Šícha, Jan Čermák   +5 more
doaj   +1 more source

Targeted and untargeted metabolomics provide insight into the consequences of glycine‐N‐methyltransferase deficiency including the novel finding of defective immune function

Physiological Reports, Volume 8, Issue 18, September 2020., 2020
Abstract Fatty liver disease is increasing along with the prevalence of obesity and type‐2 diabetes. Hepatic fibrosis is a major health complication for which there are no efficacious treatment options available. A better understanding of the fundamental mechanisms that contribute to the accumulation of fibrosis is needed.
Brandon J. Eudy, Caitlin E. McDermott, Xiuli Liu, Robin P. da Silva   +3 more
wiley   +1 more source