Results 31 to 40 of about 299,285 (291)

NAD+ homeostasis in human health and disease

EMBO Molecular Medicine, 2021
Depletion of nicotinamide adenine dinucleotide (NAD+), a central redox cofactor and the substrate of key metabolic enzymes, is the causative factor of a number of inherited and acquired diseases in humans. Primary deficiencies of NAD+ homeostasis are the
R. Zapata-Pérez, R. Wanders, C. V. van Karnebeek, R. Houtkooper   +3 more
semanticscholar   +1 more source

NAD+ surfaces again [PDF]

Biochemical Journal, 2004
NAD+ and its metabolites serve important functions in intracellular signalling. NAD+-mediated regulatory processes also take place on the cell surface, particularly of immune cells. In this issue of the Biochemical Journal, Gerth et al. have demonstrated a new mechanism of Ca2+ uptake into monocytes which is triggered by NAD+ or its degradation product,
Marc Niere, Mathias Ziegler
openaire   +3 more sources

Information and Material Support to Environmental Education in Slovakia in the Times of Crisis

Acta Educationis Generalis, 2023
Introduction: The undergoing globalization brings epidemiological, economical, energetical, and environmental security risks. The current task in the field of improving the quality of the environment is educating students in schools for adaptation to the
Bilčík Alexander, Bilčíková Jana, Lajčin Daniel, Barnová Silvia   +3 more
doaj   +1 more source

Stress Response of Miscanthus Plants and Soil Microbial Communities: A Case Study in Metals and Hydrocarbons Contaminated Soils

Applied Sciences, 2021
Second-generation biofuel crop miscanthus is one of the most promising plants tested for phytomanagement of contaminated sites. In this preliminary pot case study, the most used hybrid Miscanthus x giganteus was cultivated in three different real ...
Diana Nebeská, Hana Auer Malinská, Anna Erol, Valentina Pidlisnyuk, Pavel Kuráň, Andrea Medžová, Martin Smaha, Josef Trögl   +7 more
doaj   +1 more source

Sirtuins in the pathogenetic therapy of neurodegenerative diseases [PDF]

Клиническая практика
The progressive decline in the physiological functions during aging leads to various diseases that place a heavy burden on patients, their families and the society as a whole.
Ekaterina M. Samoilova, Alina A. Ivanova, Petr P. Laktionov, Vladimir A. Kalsin, Stanislav E. Romanov   +4 more
doaj   +1 more source

Murine iNKT cells are depleted by liver damage via activation of P2RX7

European Journal of Immunology, Volume 50, Issue 10, Page 1515-1524, October 2020., 2020
Drug‐induced liver injury activates a suicide pathway in hepatic iNKT cells. The tissue damage induced release of ATP and NAD into the extracellular space triggers the receptor P2RX7 and leads locally to a long‐lasting depletion of iNKT cells. Abstract Invariant natural killer T cells (iNKT) constitute up to 50% of liver lymphocytes and contribute to ...
Astrid A. Bovens, Thomas H. Wesselink, Felix M. Behr, Natasja A. M. Kragten, René A. W. van Lier, Klaas P. J. M. van Gisbergen, Regina Stark   +6 more
wiley   +1 more source

NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism.

Antioxidants and Redox Signaling, 2018
SIGNIFICANCE The nicotinamide adenine dinucleotide (NAD+)/reduced NAD+ (NADH) and NADP+/reduced NADP+ (NADPH) redox couples are essential for maintaining cellular redox homeostasis and for modulating numerous biological events, including cellular ...
Wusheng Xiao, Ruisheng Wang, D. Handy, J. Loscalzo   +3 more
semanticscholar   +1 more source

NAD+ Repletion Reverses Heart Failure With Preserved Ejection Fraction

Circulation Research, 2021
Supplemental Digital Content is available in the text. Rationale: Heart failure with preserved ejection fraction (HFpEF) is a mortal clinical syndrome without effective therapies.
Dan Tong, G. Schiattarella, Nan Jiang, Francisco Altamirano, P. Szweda, Abdallah Elnwasany, Dong I. Lee, Heesoo Yoo, D. Kass, L. Szweda, S. Lavandero, E. Verdin, T. Gillette, Joseph A. Hill   +13 more
semanticscholar   +1 more source

Targeted and untargeted metabolomics provide insight into the consequences of glycine‐N‐methyltransferase deficiency including the novel finding of defective immune function

Physiological Reports, Volume 8, Issue 18, September 2020., 2020
Abstract Fatty liver disease is increasing along with the prevalence of obesity and type‐2 diabetes. Hepatic fibrosis is a major health complication for which there are no efficacious treatment options available. A better understanding of the fundamental mechanisms that contribute to the accumulation of fibrosis is needed.
Brandon J. Eudy, Caitlin E. McDermott, Xiuli Liu, Robin P. da Silva   +3 more
wiley   +1 more source

CD38, CD157, and RAGE as Molecular Determinants for Social Behavior

Cells, 2019
Recent studies provide evidence to support that cluster of differentiation 38 (CD38) and CD157 meaningfully act in the brain as neuroregulators. They primarily affect social behaviors. Social behaviors are impaired in Cd38 and Cd157 knockout mice. Single-
Haruhiro Higashida, Minako Hashii, Yukie Tanaka, Shigeru Matsukawa, Yoshihiro Higuchi, Ryosuke Gabata, Makoto Tsubomoto, Noriko Seishima, Mitsuyo Teramachi, Taiki Kamijima, Tsuyoshi Hattori, Osamu Hori, Chiharu Tsuji, Stanislav M. Cherepanov, Anna A. Shabalova, Maria Gerasimenko, Kana Minami, Shigeru Yokoyama, Sei-ichi Munesue, Ai Harashima, Yasuhiko Yamamoto, Alla B. Salmina, Olga Lopatina   +22 more
doaj   +1 more source