Results 31 to 40 of about 923,736 (263)

It takes two to tango: NAD+ and sirtuins in aging/longevity control [PDF]

, 2016
The coupling of nicotinamide adenine dinucleotide (NAD+) breakdown and protein deacylation is a unique feature of the family of proteins called ‘sirtuins.’ This intimate connection between NAD+ and sirtuins has an ancient origin and provides a ...
Guarente, Leonard, Imai, Shin-ichiro
core   +2 more sources

CD38, CD157, and RAGE as Molecular Determinants for Social Behavior

Cells, 2019
Recent studies provide evidence to support that cluster of differentiation 38 (CD38) and CD157 meaningfully act in the brain as neuroregulators. They primarily affect social behaviors. Social behaviors are impaired in Cd38 and Cd157 knockout mice. Single-
Haruhiro Higashida, Minako Hashii, Yukie Tanaka, Shigeru Matsukawa, Yoshihiro Higuchi, Ryosuke Gabata, Makoto Tsubomoto, Noriko Seishima, Mitsuyo Teramachi, Taiki Kamijima, Tsuyoshi Hattori, Osamu Hori, Chiharu Tsuji, Stanislav M. Cherepanov, Anna A. Shabalova, Maria Gerasimenko, Kana Minami, Shigeru Yokoyama, Sei-ichi Munesue, Ai Harashima, Yasuhiko Yamamoto, Alla B. Salmina, Olga Lopatina   +22 more
doaj   +1 more source

Murine iNKT cells are depleted by liver damage via activation of P2RX7

European Journal of Immunology, Volume 50, Issue 10, Page 1515-1524, October 2020., 2020
Drug‐induced liver injury activates a suicide pathway in hepatic iNKT cells. The tissue damage induced release of ATP and NAD into the extracellular space triggers the receptor P2RX7 and leads locally to a long‐lasting depletion of iNKT cells. Abstract Invariant natural killer T cells (iNKT) constitute up to 50% of liver lymphocytes and contribute to ...
Astrid A. Bovens, Thomas H. Wesselink, Felix M. Behr, Natasja A. M. Kragten, René A. W. van Lier, Klaas P. J. M. van Gisbergen, Regina Stark   +6 more
wiley   +1 more source

Quantitation of intracellular NAD(P)H can monitor an imbalance of DNA single strand break repair in base excision repair deficient cells in real time [PDF]

, 2003
DNA single strand breaks (SSBs) are one of the most frequent DNA lesions in genomic DNA generated either by oxidative stress or during the base excision repair pathways.
Asakura, Shoji, Caldecott, Keith W, de Murcia, Gilbert, Hester, Susan D, Nakamura, Jun, Swenberg, James A   +5 more
core   +3 more sources

Targeted and untargeted metabolomics provide insight into the consequences of glycine‐N‐methyltransferase deficiency including the novel finding of defective immune function

Physiological Reports, Volume 8, Issue 18, September 2020., 2020
Abstract Fatty liver disease is increasing along with the prevalence of obesity and type‐2 diabetes. Hepatic fibrosis is a major health complication for which there are no efficacious treatment options available. A better understanding of the fundamental mechanisms that contribute to the accumulation of fibrosis is needed.
Brandon J. Eudy, Caitlin E. McDermott, Xiuli Liu, Robin P. da Silva   +3 more
wiley   +1 more source

Outlook of logging perspectives in the Czech Republic for the period 2013-2032

Journal of Forest Science, 2014
The aim of the submitted work was to analyze the outlook of logging perspectives in the next two decades (2013-2032) for all forests in the territory of the Czech Republic.
M. Synek, J. Vašíček, M. Zeman
doaj   +1 more source

Structural characterization of borneol dehydrogenase from Pseudomonas sp. TCU‐HL1

Acta Crystallographica Section F, Volume 76, Issue 7, Page 309-313, July 2020., 2020
The structure of a Pseudomonas borneol dehydrogenase was determined at 1.84 Å resolution. Major differences from its homologues in the C‐terminal helices and the associated loops may suggest determinants for substrate recognition.During the microbial degradation of borneol, a bicyclic plant monoterpene, it is first converted into camphor by borneol ...
Aye Aye Khine, Hao-Ping Chen, Kai-Fa Huang, Tzu-Ping Ko   +3 more
wiley   +1 more source

Vitamins Reverse Endothelial Dysfunction Through Regulation of eNOS and NAD(P)H Oxidase Activities [PDF]

, 2003
Antioxidant vitamins C and E have protective properties in genetic hypertension associated with enhanced oxidative stress. This study investigated whether vitamins C and/or E modulate vascular function by regulating enzymatic activities of endothelial ...
Bayraktutan, Ulvi, McKeown, Pascal, Ulker, Sible   +2 more
core   +2 more sources

Evolutionary Views of Tuberculosis: Indoleamine 2,3‐Dioxygenase Catalyzed Nicotinamide Synthesis Reflects Shifts in Macrophage Metabolism

BioEssays, Volume 42, Issue 5, May 2020., 2020
Classically activated macrophages upregulate Warburg‐like metabolism while alternatively activated M2 macrophages utilize the Krebs cycle and oxidative phosphorylation. M2 macrophages upregulate indoleamine 2,3‐dioxygenase for de novo nicotinamide adenine dinucleotide (NAD) synthesis.
Melinda S. Suchard, Clement G. Adu‐Gyamfi, Bridgette M. Cumming, Dana M. Savulescu   +3 more
wiley   +1 more source

A novel fluorescent probe for NAD-consuming enzymes [PDF]

, 2011
A novel, fluorescent NAD derivative is processed as substrate by three different NAD-consuming enzymes. The new probe has been used to monitor enzymatic activity in a continuous format by changes in fluorescence and, in one case, to directly visualize ...
Barrio, Belenky, Berger, Cakir-Kiefer, Capek, Collier, Gerd K. Wagner, Giulia Pergolizzi, Goulioukina, Graeff, Gruber, Guse, Jiang, Jiang, Julea N. Butt, Kahn, Kim, Lee, Legutko, Leonard, Lin, Moreau, Muller, Nottbohm, Oei, Pankiewicz, Pankiewicz, Pesnot, Pesnot, Pollak, Richard P. Bowater, Wall, Western, Wierzchowski, Wise, Zhang, Zhang, Ziegler   +37 more
core   +1 more source