Results 31 to 40 of about 999,429 (336)
Assays for NAD+-Dependent Reactions and NAD+ Metabolites [PDF]
, 2018 Nicotinamide adenine dinucleotide (NAD+) is an essential redox cofactor and signaling molecule that controls the activity of enzymes involved in metabolism, DNA repair, and cellular survival, such as the PARPs, CD38, and the sirtuins. Here, we describe three methods for measuring the activity of these enzymes: the etheno-NAD+ assay measures NAD ...
David A. Sinclair +4 more
openaire +2 more sources
NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential
Signal Transduction and Targeted Therapy, 2020 Nicotinamide adenine dinucleotide (NAD + ) and its metabolites function as critical regulators to maintain physiologic processes, enabling the plastic cells to adapt to environmental changes including nutrient perturbation, genotoxic factors, circadian ...
N. Xie +8 more
semanticscholar +1 more source
Journal of Neuroinflammation, 2021 Microglial-mediated neuroinflammation plays an important role in vascular dementia, and modulating neuroinflammation has emerged as a promising treatment target. Nicotinamide adenine dinucleotide (NAD+) shows anti-inflammatory and anti-oxidant effects in
Yao Zhao +9 more
semanticscholar +1 more source
Journal of Cellular and Molecular Medicine, Volume 25, Issue 13, Page 5884-5898, July 2021., 2021 Abstract Nicotinamide adenine dinucleotide (NAD+) is crucial for cell energy metabolism and many signalling processes. Recently, we proved the role of ecto‐enzymes in controlling adenine nucleotide–dependent pathways during calcific aortic valve disease (CAVD).
Patrycja Jablonska +9 more
wiley +1 more source
Grabbing the genome by the NADs [PDF]
Chromosoma, 2015 The regions of the genome that interact frequently with the nucleolus have been termed nucleolar-associated domains (NADs). Deep sequencing and DNA-fluorescence in situ hybridization (FISH) experiments have revealed that these domains are enriched for repetitive elements, regions of the inactive X chromosome (Xi), and several RNA polymerase III ...
Matheson, Timothy D., Kaufman, Paul D.
openaire +4 more sources
Development of the Cerebrospinal Fluid in Early Stage after Hemorrhage in the Central Nervous System
Life, 2021 Extravasation of blood in the central nervous system (CNS) represents a very strong damaged associated molecular patterns (DAMP) which is followed by rapid inflammation and can participate in worse outcome of patients.
Petr Kelbich +10 more
doaj +1 more source
Increased demand for NAD+ relative to ATP drives aerobic glycolysis
bioRxiv, 2020 Aerobic glycolysis, or preferential fermentation of glucose-derived pyruvate to lactate despite available oxygen, is a hallmark of proliferative metabolism that is observed across many organisms and conditions. To better understand why aerobic glycolysis
Alba Luengo +13 more
semanticscholar +1 more source
Biochemical Journal, 2004 NAD+ and its metabolites serve important functions in intracellular signalling. NAD+-mediated regulatory processes also take place on the cell surface, particularly of immune cells. In this issue of the Biochemical Journal, Gerth et al. have demonstrated a new mechanism of Ca2+ uptake into monocytes which is triggered by NAD+ or its degradation product,
Marc Niere, Mathias Ziegler
openaire +3 more sources
mBio, 2023 ABSTRACT Nicotinamide adenine dinucleotide (NAD) and its phosphorylated derivative (NADP) are essential cofactors that participate in hundreds of biochemical reactions and have emerged as therapeutic targets in cancer, metabolic disorders, neurodegenerative diseases, and infections, including tuberculosis.
Ritu Sharma +11 more
openaire +3 more sources
The essential schistosome tegumental ectoenzyme SmNPP5 can block NAD-induced T cell apoptosis
Virulence, 2020 Infection with intravascular platyhelminths of the genus Schistosoma can result in the debilitating disease schistosomiasis. Schistosomes (blood flukes) can survive in the host for many years.
Catherine S. Nation +2 more
doaj +1 more source