Results 31 to 40 of about 205,573 (216)

Grabbing the genome by the NADs [PDF]

open access: yesChromosoma, 2015
The regions of the genome that interact frequently with the nucleolus have been termed nucleolar-associated domains (NADs). Deep sequencing and DNA-fluorescence in situ hybridization (FISH) experiments have revealed that these domains are enriched for repetitive elements, regions of the inactive X chromosome (Xi), and several RNA polymerase III ...
Matheson, Timothy D., Kaufman, Paul D.
openaire   +4 more sources

The new insight into extracellular NAD+ degradation‐the contribution of CD38 and CD73 in calcific aortic valve disease

open access: yesJournal of Cellular and Molecular Medicine, Volume 25, Issue 13, Page 5884-5898, July 2021., 2021
Abstract Nicotinamide adenine dinucleotide (NAD+) is crucial for cell energy metabolism and many signalling processes. Recently, we proved the role of ecto‐enzymes in controlling adenine nucleotide–dependent pathways during calcific aortic valve disease (CAVD).
Patrycja Jablonska   +9 more
wiley   +1 more source

NAD+ surfaces again [PDF]

open access: yesBiochemical Journal, 2004
NAD+ and its metabolites serve important functions in intracellular signalling. NAD+-mediated regulatory processes also take place on the cell surface, particularly of immune cells. In this issue of the Biochemical Journal, Gerth et al. have demonstrated a new mechanism of Ca2+ uptake into monocytes which is triggered by NAD+ or its degradation product,
Marc Niere, Mathias Ziegler
openaire   +3 more sources

Sirtuins in the pathogenetic therapy of neurodegenerative diseases [PDF]

open access: yesКлиническая практика
The progressive decline in the physiological functions during aging leads to various diseases that place a heavy burden on patients, their families and the society as a whole.
Ekaterina M. Samoilova   +4 more
doaj   +1 more source

The essential schistosome tegumental ectoenzyme SmNPP5 can block NAD-induced T cell apoptosis

open access: yesVirulence, 2020
Infection with intravascular platyhelminths of the genus Schistosoma can result in the debilitating disease schistosomiasis. Schistosomes (blood flukes) can survive in the host for many years.
Catherine S. Nation   +2 more
doaj   +1 more source

The evaluation of possibilities of sustainable tourism and recreation in the Mrtva Tisa area near Čurug7 [PDF]

open access: yesGlasnik Srpskog Geografskog Društva, 2008
The preserved parts of the nature or areas that are inteded to be protected and well-planned in terms of harmonizing the nature and tourist activities and recreation could become potential eco-tourist attractions.
Nađ Imre
doaj   +1 more source

Metabolically distinct roles of NAD synthetase and NAD kinase define the essentiality of NAD and NADP in Mycobacterium tuberculosis

open access: yesmBio, 2023
ABSTRACT Nicotinamide adenine dinucleotide (NAD) and its phosphorylated derivative (NADP) are essential cofactors that participate in hundreds of biochemical reactions and have emerged as therapeutic targets in cancer, metabolic disorders, neurodegenerative diseases, and infections, including tuberculosis.
Ritu Sharma   +11 more
openaire   +3 more sources

Historical Agricultural Landforms—Central European Bio-Cultural Heritage Worthy of Attention

open access: yesLand, 2022
Knowledge about past agricultural land management can bring solutions for future needs. One undervalued historical type of historical rural landscape in temperate Europe is termed plužiny.
Johana Zacharová   +9 more
doaj   +1 more source

CD38, CD157, and RAGE as Molecular Determinants for Social Behavior

open access: yesCells, 2019
Recent studies provide evidence to support that cluster of differentiation 38 (CD38) and CD157 meaningfully act in the brain as neuroregulators. They primarily affect social behaviors. Social behaviors are impaired in Cd38 and Cd157 knockout mice. Single-
Haruhiro Higashida   +22 more
doaj   +1 more source

Development of the Cerebrospinal Fluid in Early Stage after Hemorrhage in the Central Nervous System

open access: yesLife, 2021
Extravasation of blood in the central nervous system (CNS) represents a very strong damaged associated molecular patterns (DAMP) which is followed by rapid inflammation and can participate in worse outcome of patients.
Petr Kelbich   +10 more
doaj   +1 more source

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