Results 111 to 120 of about 11,490,346 (250)

Basal NAD(H) redox state permits hydrogen peroxide-induced mesenteric artery dilatation. [PDF]

J Physiol, 2023
Raph SM, Dwenger MM, Hu X, Nystoriak MA.
europepmc   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Cooperation between subcellular NAD pools in the maintenance of NAD-dependent processes [PDF]

, 2018
Nicotinamide adenine dinucleotide (NAD) is needed as a cofactor in several processes throughout the cell, and its availability is decisive for the activity of many NAD-dependent enzymes.
Tolås, Ingvill
core  

Mitochondrial rewiring drives metabolic adaptation to NAD(H) shortage in triple negative breast cancer cells. [PDF]

Neoplasia, 2023
Carreira ASA, Ravera S, Zucal C, Thongon N, Caffa I, Astigiano C, Bertola N, Buongiorno A, Roccuzzo M, Bisio A, Pardini B, Nencioni A, Bruzzone S, Provenzani A.   +13 more
europepmc   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Dysregulated NAD(H) homeostasis associated with ciprofloxacin tolerance in Escherichia coli investigated on a single-cell level with the Peredox [NADH:NAD+] biosensor. [PDF]

Front Microbiol, 2023
Urbaniec J, Sanderson-Smith M, McFadden J, Hai FI, Hingley-Wilson SM.   +4 more
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Peroxisomal NAD(H) Homeostasis in the Yeast <i>Debaryomyces hansenii</i> Depends on Two Redox Shuttles and the NAD⁺ Carrier, Pmp47. [PDF]

Biomolecules, 2023
Turkolmez S, Chornyi S, Alhajouj S, IJlst L, Waterham HR, Mitchell PJ, Hettema EH, van Roermund CWT.   +7 more
europepmc   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Redox Regulation and Metabolic Dependency of Zika Virus Replication: Inhibition by Nrf2-Antioxidant Response and NAD(H) Antimetabolites. [PDF]

J Virol, 2023
Sahoo BR, Crook AA, Pattnaik A, Torres-Gerena AD, Khalimonchuk O, Powers R, Franco R, Pattnaik AK.   +7 more
europepmc   +1 more source