Results 121 to 130 of about 11,490,346 (250)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

The cation exchanger Letm1, circadian rhythms, and NAD(H) levels interconnect in diurnal zebrafish. [PDF]

Life Sci Alliance, 2022
Dao P, Hajny S, Mekis R, Orel L, Dinhopl N, Tessmar-Raible K, Nowikovsky K.   +6 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Biomimetic in situ Regeneration of Cofactors NAD(P)(+) and NAD(P)H Models Hantzsch Esters and Dihydrophenanthridine

, 2012
Biomimetic recycling of the expensive cofactors NAD(P)H/NAD(P)(+) and their models is a promising area in bio-inspired synthesis. This paper highlights the recent advances in the in situ regeneration of the oxidized cofactors NAD(P)(+) through oxidation ...
Du, Wangming, Yu, Zhengkun
core   +1 more source

NAD(H)-loaded nanoparticles for efficient sepsis therapy via modulating immune and vascular homeostasis. [PDF]

Nat Nanotechnol, 2022
Ye M, Zhao Y, Wang Y, Xie R, Tong Y, Sauer JD, Gong S.   +6 more
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Alternative NAD(P)H dehydrogenases of plant mitochondria

, 2004
Plant mitochondria have a highly branched electron transport chain that provides great flexibility for oxidation of cytosolic and matrix NAD(P)H. In addition to the universal electron transport chain found in many organisms, plants have alternative NAD(P)
Soole, KL, Soole, Kathleen Lydia, Elthon, TE, Elthon, T E, Rasmusson, Allan, Rasmusson, K   +5 more
core   +2 more sources

NAD(H)-mediated tetramerization controls the activity of Legionella pneumophila phospholipase PlaB. [PDF]

Proc Natl Acad Sci U S A, 2021
Diwo M, Michel W, Aurass P, Kuhle-Keindorf K, Pippel J, Krausze J, Wamp S, Lang C, Blankenfeldt W, Flieger A.   +9 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Impact of arginine-vasopressin on regional perfusions in a porcine model of post-resuscitation syndrome

Resuscitation Plus
Background: Post-cardiac arrest (CA) shock is associated with multiple organ failure, including acute kidney injury, and is the leading cause of early death among patient successfully resuscitated from CA. Arginine-vasopressin (AVP) may be an interesting
Antoine Bois, Yara Abi Zeid Daou, Naoto Watanabe, Ali Jendoubi, Fanny Lidouren, Estelle Faucher, Nadir Mouri, Bijan Ghaleh, Guillaume Geri, Renaud Tissier, Matthias Kohlhauer   +10 more
doaj   +1 more source