Negative cooperativity in NAD(P)H quinone oxidoreductase 1 (NQO1) [PDF]
, 2019 NAD(P)H quinone oxidoreductase-1 (NQO1) is a homodimeric protein that acts as a detoxifying enzyme or as a chaperone protein. Dicourmarol interacts with NQO1 at the NAD(P)H binding site and can both inhibit enzyme activity and modulate the interaction of
Stratford, Ian J. +28 more
core +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Mitochondrial rewiring drives metabolic adaptation to NAD(H) shortage in triple negative breast cancer cells. [PDF]
Neoplasia, 2023 Carreira ASA +13 more
europepmc +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Dysregulated NAD(H) homeostasis associated with ciprofloxacin tolerance in Escherichia coli investigated on a single-cell level with the Peredox [NADH:NAD+] biosensor. [PDF]
Front Microbiol, 2023 Urbaniec J +4 more
europepmc +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Peroxisomal NAD(H) Homeostasis in the Yeast <i>Debaryomyces hansenii</i> Depends on Two Redox Shuttles and the NAD<sup>+</sup> Carrier, Pmp47. [PDF]
Biomolecules, 2023 Turkolmez S +7 more
europepmc +1 more source
, 2012 以辅酶NAD(P)H 模拟物-Hantzsch 酯作为氢源的不对称转移氢化已经得到了迅猛的发 展。但目前采用Hantzsch 酯均为化学计量，无法实现循环利用。本论文研究了两种辅酶 NAD(P)H 模拟物（Hantzsch 酯和二氢菲啶）的原位再生循环并将其用于仿生不对称氢化反 应。 首先采用[Ru(p-cymene)I2]2 和手性磷酸作为接力催化剂，在1000 psi H2 条件下，实现 了辅酶NAD(P)H 模拟物-Hantzsch 酯的原位再生循环，并将其用于苯并噁嗪酮的仿生不对 称氢化 ...
陈庆安
core
Comparative life cycle assessment of NAD(P)H regeneration technologies
, 2021 NAD(P)H is a key cofactor widely used in biocatalytic reductive transformations, facilitating a wide range of industrially significant reactions which ultimately result in the consumption of the costly cofactor.
Sun, Ziying +4 more
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source