NAD(H) Regulates the Permeability Transition Pore in Mitochondria through an External Site. [PDF]
Int J Mol Sci, 2021 Kharechkina E, Nikiforova A, Kruglov A.
europepmc +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Monitoring NAD(H) and NADP(H) dynamics during organismal development with genetically encoded fluorescent biosensors. [PDF]
Cell Regen, 2022 Li T +5 more
europepmc +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
, 2012 以辅酶NAD(P)H 模拟物-Hantzsch 酯作为氢源的不对称转移氢化已经得到了迅猛的发 展。但目前采用Hantzsch 酯均为化学计量，无法实现循环利用。本论文研究了两种辅酶 NAD(P)H 模拟物（Hantzsch 酯和二氢菲啶）的原位再生循环并将其用于仿生不对称氢化反 应。 首先采用[Ru(p-cymene)I2]2 和手性磷酸作为接力催化剂，在1000 psi H2 条件下，实现 了辅酶NAD(P)H 模拟物-Hantzsch 酯的原位再生循环，并将其用于苯并噁嗪酮的仿生不对 称氢化 ...
陈庆安
core
Feasibility of Non-invasive Measurement of Tumour NAD(H) by In Vivo Phosphorus-31 Magnetic Resonance Spectroscopy. [PDF]
Adv Exp Med Biol, 2022 Nath K +4 more
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Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Indirect Export of Reducing Equivalents From the Chloroplast to Resupply NADP for C3 Photosynthesis-Growing Importance for Stromal NAD(H)? [PDF]
Front Plant Sci, 2021 Krämer M, Kunz HH.
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Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source