Results 131 to 140 of about 158,023 (302)

Redox Regulation and Metabolic Dependency of Zika Virus Replication: Inhibition by Nrf2-Antioxidant Response and NAD(H) Antimetabolites. [PDF]

J Virol, 2023
Sahoo BR, Crook AA, Pattnaik A, Torres-Gerena AD, Khalimonchuk O, Powers R, Franco R, Pattnaik AK.   +7 more
europepmc   +1 more source

Mean plasma levels of NAD⁺, Total NAD(H), and NAD⁺/NADH ratio across tertiles of plasma urea.

, 2018
*Data represented as square root NAD+, **Data represented as base-10 log-transformed Total NAD(H), and NAD+/NADH ratio. a significantly different compared to 1st tertile.
Ross Grant (313891), Jade Berg (4573705), Neda Seyedsadjadi (4573708), Nady Braidy (261733), Ayse A. Bilgin (4573702), Chris Salonikas (5638388)   +5 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The cation exchanger Letm1, circadian rhythms, and NAD(H) levels interconnect in diurnal zebrafish. [PDF]

Life Sci Alliance, 2022
Dao P, Hajny S, Mekis R, Orel L, Dinhopl N, Tessmar-Raible K, Nowikovsky K.   +6 more
europepmc   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

NAD(H)-loaded nanoparticles for efficient sepsis therapy via modulating immune and vascular homeostasis. [PDF]

Nat Nanotechnol, 2022
Ye M, Zhao Y, Wang Y, Xie R, Tong Y, Sauer JD, Gong S.   +6 more
europepmc   +1 more source

Evidence for gene duplication forming similar binding folds for NAD(P)H and FAD in pyridine nucleotide-dependent flavoenzymes

, 1991
For pyridine nucleotide-dependent flavoezymes, binding both FAD and NAD(P)H on a single amino-acids chain, we have found a high degree of internal sequence similarity for certain regions of FAD and NAD (P)H binding portions of the chain for any given ...
McKie, James H., Douglas, Kenneth T.; id_orcid, James H. McKie, Douglas, Kenneth T., Kenneth T. Douglas   +4 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

NAD(H) Regulates the Permeability Transition Pore in Mitochondria through an External Site. [PDF]

Int J Mol Sci, 2021
Kharechkina E, Nikiforova A, Kruglov A.
europepmc   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source