Results 251 to 260 of about 158,023 (302)
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Tetrahedron, 1986
Abstract NAD(P)H/NAD(P) + and related compounds have intrinsic chirality against the axis alone the C 3 –C carbonyl single bond. A model compound which has a stable conformation with respect to this chirality was synthesized and the conformational relationship between the carbonyl dipole and the reacting hydrogen was studied.
Atsuyoshi Ohno +4 more
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Abstract NAD(P)H/NAD(P) + and related compounds have intrinsic chirality against the axis alone the C 3 –C carbonyl single bond. A model compound which has a stable conformation with respect to this chirality was synthesized and the conformational relationship between the carbonyl dipole and the reacting hydrogen was studied.
Atsuyoshi Ohno +4 more
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NAD(P)H Oxidases and Their Relevance to Atherosclerosis
Trends in Cardiovascular Medicine, 2001Studies performed during the last decade have identified NAD(P)H oxidases unique to nonphagocytic vascular cells. The reactive oxygen species released from these enzymes regulate fundamental cellular functions such as growth (hyperplastic or hypertrophic), endothelial dysfunction, migration and inflammation, which have been demonstrated to play a role ...
D, Sorescu, K, Szöcs, K K, Griendling
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NAD(P)H Oxidase and Endothelial Dysfunction
Hormone and Metabolic Research, 2008The regulation of endothelial function plays an important role in the development and progression of metabolic and cardiovascular diseases. A critical determinant of endothelial function is the balance between nitric oxide and reactive oxygen species.
G, Muller, H, Morawietz
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Vanadate-stimulated oxidation of NAD(P)H
Free Radical Biology and Medicine, 1989Vanadate stimulates the oxidation of NAD(P)H by biological membranes because such membranes contain NAD(P)H oxidases which are capable of reducing dioxygen to O2- and because vanadate catalyzes the oxidation of NAD(P)H by O2-, by a free radical chain mechanism.
S I, Liochev, I, Fridovich
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NAD(P)+-NAD(P)H Model. 46. Kinetic study on the reduction with a sulfur-containing NAD(P)H model
Tetrahedron Letters, 1983Abstract Kinetics on the reduction with an NAD(P)H model bearing a divalent sulfur atom in the N-alkyl substituent has been studied. The sulfur atom retards the electron-transfer process.
Atsuyoshi Ohno +3 more
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Tetrahedron Letters, 1999
Abstract In oxidation of NAD(P)H analog with p-benzoquinone derivatives in the presence of Mg 2+ , it has been found that the reactivity of syn-hydrogen becomes larger as the reduction potential of p -benzoquinone derivative decreases. The selectivity shifts toward the syn-preferency in the presence of Mg 2+ from the anti -preferency in the ...
Atsuyoshi Ohno +2 more
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Abstract In oxidation of NAD(P)H analog with p-benzoquinone derivatives in the presence of Mg 2+ , it has been found that the reactivity of syn-hydrogen becomes larger as the reduction potential of p -benzoquinone derivative decreases. The selectivity shifts toward the syn-preferency in the presence of Mg 2+ from the anti -preferency in the ...
Atsuyoshi Ohno +2 more
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The simultaneous determination of NAD(H) and NADP(H) utilization by glutamate dehydrogenase
Molecular and Cellular Biochemistry, 2010Glutamate dehydrogenase (GDH) from vertebrates is unusual among NAD(P)H-dependent dehydrogenases in that it can use either NAD(H) or NADP(H) as cofactor. In this study, we measure the rate of cofactor utilization by bovine GDH when both cofactors are present. Methods for both reaction directions were developed, and for the first time, to our knowledge,
Jason R, Treberg +2 more
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Inhibition of NAD(H)/NADP(H) — requiring enzymes by aurintricarboxylic acid
Toxicology Letters, 1995Aurintricarboxylic acid (ATA), an inhibitor of Ca(2+)-dependent endonuclease activity, is often used to implicate a role for increased intracellular calcium in mechanistic toxicology studies. We report here on the ability of ATA to inhibit the activity of several NAD(H)/NADP(H)-requiring enzymes (purified or cellular homogenates), including lactic ...
D C, Thompson, M, Reed
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Chemischer Informationsdienst, 1985
AbstractDie als‐ungesättigten Nitroolefine (I) werden durch das Dihydropyridin (II) als NAD(P)H‐Modellsubstanz in Gegenwart von Silicagel zu den Nitroalkanen (III) reduziert.
K. NAKAMURA, M. FUJII, S. OKA, A. OHNO
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AbstractDie als‐ungesättigten Nitroolefine (I) werden durch das Dihydropyridin (II) als NAD(P)H‐Modellsubstanz in Gegenwart von Silicagel zu den Nitroalkanen (III) reduziert.
K. NAKAMURA, M. FUJII, S. OKA, A. OHNO
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1986
Nicotinamide adenine dinucleotide and its phosphate derivative are widely distributed as coenzymes for biological redox reactions. Structures of their oxidized and reduced forms are depicted above. Within the coenzyme molecule, the nicotinamide moiety which is linked with a ribose moiety through a β-glycosidic bond* acts as a shuttle redox reagent by ...
Atsuyoshi Ohno, Satoshi Ushida
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Nicotinamide adenine dinucleotide and its phosphate derivative are widely distributed as coenzymes for biological redox reactions. Structures of their oxidized and reduced forms are depicted above. Within the coenzyme molecule, the nicotinamide moiety which is linked with a ribose moiety through a β-glycosidic bond* acts as a shuttle redox reagent by ...
Atsuyoshi Ohno, Satoshi Ushida
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