Results 31 to 40 of about 11,490,346 (250)

Simultaneous NAD(P)H and FAD fluorescence lifetime microscopy of long UVA–induced metabolic stress in reconstructed human skin

Scientific Reports, 2021
Solar ultraviolet longwave UVA1 exposure of human skin has short-term consequences at cellular and molecular level, leading at long-term to photoaging. Following exposure, reactive oxygen species (ROS) are generated, inducing oxidative stress that might ...
Thi Phuong Lien Ung, Seongbin Lim, Xavier Solinas, Pierre Mahou, Anatole Chessel, Claire Marionnet, Thomas Bornschlögl, Emmanuel Beaurepaire, Françoise Bernerd, Ana-Maria Pena, Chiara Stringari   +10 more
doaj   +1 more source

Catalytic recycling of NAD(P)H

, 2021
A large number of industrially relevant enzymes depend upon dihydronicotinamide adenine dinucleotide (NADH) and dihydronicotinamide adenine dinucleotide phosphate (NADPH) cofactors, which are too expensive to be added in stoichiometric amounts.
이용민, 남원우, Shunichi Fukuzumi
core   +1 more source

EXTRACELLULAR NICOTINAMIDE ADENINE DINUCLEOTIDE (NAD) ARRESTS ENDOTHELIAL CELL PROLIFERATION

, 2022
Background: presence of NAD in the extracellular environment acts as an autocrine/paracrine signal in different cell types (including smooth myocytes, neurons, human hematopoietic stem cells, granulocytes), mediating inflammatory responses, cell ...
Christian Di Buduo, Antonella Antonelli, Alessandra Balduini, Santina Bruzzone, Francesco Piacente, Cecilia Astigiano, Michele Cea, Maria Elena Laugieri, Mauro Magnani, Andrea Benzi, Debora Soncini   +10 more
core   +1 more source

Induction of the nicotinamide riboside kinase NAD+ salvage pathway in a model of sarcoplasmic reticulum dysfunction

Skeletal Muscle, 2020
Background Hexose-6-Phosphate Dehydrogenase (H6PD) is a generator of NADPH in the Endoplasmic/Sarcoplasmic Reticulum (ER/SR). Interaction of H6PD with 11β-hydroxysteroid dehydrogenase type 1 provides NADPH to support oxo-reduction of inactive to active ...
Craig L. Doig, Agnieszka E. Zielinska, Rachel S. Fletcher, Lucy A. Oakey, Yasir S. Elhassan, Antje Garten, David Cartwright, Silke Heising, Ahmed Alsheri, David G. Watson, Cornelia Prehn, Jerzy Adamski, Daniel A. Tennant, Gareth G. Lavery   +13 more
doaj   +1 more source

Nitric oxide synthase and NAD(P)H oxidase modulate coronary endothelial cell growth [PDF]

, 2004
Reactive oxygen species (ROS) including nitric oxide (NO) and superoxide anion (O2-) are associated with cell migration, proliferation and many growth-related diseases.
U Bayraktutan, Bayraktutan, Ulvi
core   +1 more source

NAD(H) recycling activity of an engineered bifunctional enzyme galactose dehydrogenase/lactate dehydrogenase-0

, 2011
Copyright information:Taken from "NAD(H) recycling activity of an engineered bifunctional enzyme galactose dehydrogenase/lactate dehydrogenase"International Journal of Biological Sciences 2006;2(1):10-16.Published online 1 Mar 2006PMCID:PMC1415851 ...
Chartchalerm Isarankura-Na-Ayudhya (13696), Virapong Prachayasittikul (13700), Sarah Ljung (15816), Leif Bülow (15817)   +3 more
core   +1 more source

A nonrandomized study of single oral supplementation within the daily tolerable upper level of nicotinamide affects blood nicotinamide and NAD+ levels in healthy subjects

Translational Medicine of Aging, 2020
A decrease in nicotinamide adenine dinucleotide (NAD+) levels is a hallmark of aging in multiple organisms, including humans. We report a human clinical trial designed to assess the efficacy of single-dose supplementation of nicotinamide, a form of ...
Takashi K. Ito, Tomohito Sato, Akio Hakamata, Yuki Onoda, Shumpei Sato, Fumiyoshi Yamazaki, Makoto Horikawa, Yutaka Takahashi, Takuya Kitamoto, Masako Suzuki, Shinya Uchida, Keiichi Odagiri, Mitsutoshi Setou   +12 more
doaj   +1 more source

Intravital Metabolic Autofluorescence Imaging Captures Macrophage Heterogeneity Across Normal and Cancerous Tissue

Frontiers in Bioengineering and Biotechnology, 2021
Macrophages are dynamic immune cells that govern both normal tissue function and disease progression. However, standard methods to measure heterogeneity in macrophage function within tissues require tissue excision and fixation, which limits our ...
Tiffany M. Heaster, Tiffany M. Heaster, Alexa R. Heaton, Alexa R. Heaton, Paul M. Sondel, Paul M. Sondel, Melissa C. Skala, Melissa C. Skala   +7 more
doaj   +1 more source

A novel whole-cell biocatalyst with NAD+ regeneration for production of chiral chemicals. [PDF]

PLoS ONE, 2010
BACKGROUND: The high costs of pyridine nucleotide cofactors have limited the applications of NAD(P)-dependent oxidoreductases on an industrial scale.
Zijun Xiao, Chuanjuan Lv, Chao Gao, Jiayang Qin, Cuiqing Ma, Zhen Liu, Peihai Liu, Lixiang Li, Ping Xu   +8 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source