Results 11 to 20 of about 11,490,346 (250)

Mitochondrial Impairment May Increase Cellular NAD(P)H: Resazurin Oxidoreductase Activity, Perturbing the NAD(P)H-Based Viability Assays

Cells, 2015
Cellular NAD(P)H-dependent oxidoreductase activity with artificial dyes (NAD(P)H-OR) is an indicator of viability, as the cellular redox state is important for biosynthesis and antioxidant defense.
Vasily A. Aleshin, Artem V. Artiukhov, Henry Oppermann, Alexey V. Kazantsev, Nikolay V. Lukashev, Victoria I. Bunik   +5 more
doaj   +2 more sources

Endogenous mitochondrial NAD(P)H fluorescence can predict lifespan

Communications Biology
Many aging clocks have recently been developed to predict health outcomes and deconvolve heterogeneity in aging. However, existing clocks are limited by technical constraints, such as low spatial resolution, long processing time, sample destruction, and ...
Christopher S. Morrow, Pallas Yao, Carlos A. Vergani-Junior, Praju Vikas Anekal, Paula Montero Llopis, Jeffrey W. Miller, Bérénice A. Benayoun, William B. Mair   +7 more
doaj   +2 more sources

The Prospective Synergy of Antitubercular Drugs With NAD Biosynthesis Inhibitors [PDF]

, 2021
Given the upsurge of drug-resistant tuberculosis worldwide, there is much focus on developing novel drug combinations allowing shorter treatment duration and a lower toxicity profile.
Sorci L., Rohde K. H.
core   +1 more source

Label-free characterization of single extracellular vesicles using two-photon fluorescence lifetime imaging microscopy of NAD(P)H

Scientific Reports, 2021
The heterogeneous nature of extracellular vesicles (EVs) creates the need for single EV characterization techniques. However, many common biochemical and functional EV analysis techniques lack single EV resolution.
Janet E. Sorrells, Elisabeth M. Martin, Edita Aksamitiene, Prabuddha Mukherjee, Aneesh Alex, Eric J. Chaney, Marina Marjanovic, Stephen A. Boppart   +7 more
doaj   +1 more source

Redox modulation of NQO1. [PDF]

PLoS ONE, 2018
NQO1 is a FAD containing NAD(P)H-dependent oxidoreductase that catalyzes the reduction of quinones and related substrates. In cells, NQO1 participates in a number of binding interactions with other proteins and mRNA and these interactions may be ...
David Siegel, Donna D Dehn, Samantha S Bokatzian, Kevin Quinn, Donald S Backos, Andrea Di Francesco, Michel Bernier, Nichole Reisdorph, Rafael de Cabo, David Ross   +9 more
doaj   +1 more source

Cytochemical Localization of NAD (P) H Oxidase in the Myoepithelial Cells of Salivary and Other Exocrine Glands [PDF]

, 1995
Cytochemical localization of NAD (P) H oxidase, a hydrogen-peroxide generating enzyme, has been investigated using the cerium method in several mammalian exocrine glands: (a) salivary glands of the rat, Mongolian gerbil, house musk shrew and man, (b ...
Yasuhisa Inoue, Kunio Takano, Miyazaki, Toshihiro, Takano, Kunio, Inoue, Yasuhisa, Toshihiro Miyazaki   +5 more
core   +1 more source

Defining NAD(P)(H) Catabolism

, 2023
Dietary vitamin B3 components, such as nicotinamide and nicotinic acid, are precursors to the ubiquitous redox cofactor nicotinamide adenine dinucleotide (NAD+). NAD+ levels are thought to decline with age and disease.
Marie E. Migaud, Jyothi Dhuguru, Ryan W. Dellinger   +2 more
core   +1 more source

Metabolic engineering of Escherichia coli for l-malate production anaerobically

Microbial Cell Factories, 2020
Background l-malate is one of the most important platform chemicals widely used in food, metal cleaning, textile finishing, pharmaceuticals, and synthesis of various fine chemicals. Recently, the development of biotechnological routes to produce l-malate
Youming Jiang, Tianwen Zheng, Xiaohan Ye, Fengxue Xin, Wenming Zhang, Weiliang Dong, Jiangfeng Ma, Min Jiang   +7 more
doaj   +1 more source

Metabolic changes associated with dark-induced leaf senescence in Arabidopsis nadk2 mutants

Plant Signaling & Behavior, 2023
Arabidopsis NADK2 (NAD kinase 2) is a chloroplast-localized enzyme involved in NADP+ synthesis, which acts as the final electron acceptor in the photosynthetic electron transfer chain.
chaomurilege, Atsuko Miyagi, Toshiki Ishikawa, Masatoshi Yamaguchi, Hideki Murayama, Maki Kawai-Yamada   +5 more
doaj   +1 more source

A Simple, Fast, Sensitive LC-MS/MS Method to Quantify NAD(H) in Biological Samples: Plasma NAD(H) Measurement to Monitor Brain Pathophysiology. [PDF]

Int J Mol Sci
Nicotinamide adenine dinucleotide (NAD) is a cofactor in redox reactions and an essential mediator of energy metabolism. The redox balance between NAD+ and NADH affects various diseases, cell differentiation, and aging, and in recent years there has been
Ishima T, Kimura N, Kobayashi M, Nagai R, Osaka H, Aizawa K.   +5 more
europepmc   +2 more sources