Results 11 to 20 of about 158,023 (302)
Nutrients, 2023 Dietary vitamin B3 components, such as nicotinamide and nicotinic acid, are precursors to the ubiquitous redox cofactor nicotinamide adenine dinucleotide (NAD+). NAD+ levels are thought to decline with age and disease. While the drivers of this decline remain under intense investigation, strategies have emerged seeking to functionally maintain NAD ...
Jyothi Dhuguru +2 more
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Cells, 2015 Cellular NAD(P)H-dependent oxidoreductase activity with artificial dyes (NAD(P)H-OR) is an indicator of viability, as the cellular redox state is important for biosynthesis and antioxidant defense.
Vasily A. Aleshin +5 more
doaj +2 more sources
Catalytic recycling of NAD(P)H
Journal of Inorganic Biochemistry, 2019 A large number of industrially relevant enzymes depend upon dihydronicotinamide adenine dinucleotide (NADH) and dihydronicotinamide adenine dinucleotide phosphate (NADPH) cofactors, which are too expensive to be added in stoichiometric amounts. Existing NAD(P)H-recycling systems suffer from low activity, or the generation of side products.
Shunichi, Fukuzumi +2 more
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Towards Recyclable NAD(P)H Regeneration Catalysts [PDF]
Molecules, 2012 Rh(III)-TsDPEN, an immobilized analog of the well-known [Cp<strong>*</strong>Rh(bpy)(H<sub>2</sub>O)]<sup>2+</sup> was evaluated as a heterogeneous, recyclable regeneration catalyst for reduced oxidoreductase cofactors
Frank Hollmann +4 more
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Catalases are NAD(P)H-dependent tellurite reductases. [PDF]
PLoS ONE, 2006 Reactive oxygen species damage intracellular targets and are implicated in cancer, genetic disease, mutagenesis, and aging. Catalases are among the key enzymatic defenses against one of the most physiologically abundant reactive oxygen species, hydrogen ...
Iván L Calderón +9 more
doaj +8 more sources
Endogenous mitochondrial NAD(P)H fluorescence can predict lifespan
Communications BiologyMany aging clocks have recently been developed to predict health outcomes and deconvolve heterogeneity in aging. However, existing clocks are limited by technical constraints, such as low spatial resolution, long processing time, sample destruction, and ...
Christopher S. Morrow +7 more
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NAD(H) and NADP(H) in plants and mammals.
Mol PlantNicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) are essential metabolic coenzymes in prokaryotic and eukaryotic cells, with their reduced forms, NAD(P)H, serving as electron donors for myriad reactions.
Lu D, Grant M, Lim BL.
europepmc +3 more sources
A Simple, Fast, Sensitive LC-MS/MS Method to Quantify NAD(H) in Biological Samples: Plasma NAD(H) Measurement to Monitor Brain Pathophysiology. [PDF]
Int J Mol SciNicotinamide adenine dinucleotide (NAD) is a cofactor in redox reactions and an essential mediator of energy metabolism. The redox balance between NAD+ and NADH affects various diseases, cell differentiation, and aging, and in recent years there has been
Ishima T +5 more
europepmc +2 more sources
The Prospective Synergy of Antitubercular Drugs With NAD Biosynthesis Inhibitors [PDF]
, 2021 Given the upsurge of drug-resistant tuberculosis worldwide, there is much focus on developing novel drug combinations allowing shorter treatment duration and a lower toxicity profile.
Sorci L., Rohde K. H.
core +1 more source
Redox modulation of NQO1. [PDF]
PLoS ONE, 2018 NQO1 is a FAD containing NAD(P)H-dependent oxidoreductase that catalyzes the reduction of quinones and related substrates. In cells, NQO1 participates in a number of binding interactions with other proteins and mRNA and these interactions may be ...
David Siegel +9 more
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