Results 61 to 70 of about 11,490,346 (250)

Aluminium effects on pyridine nucleotide redox state in roots of Scots pine

Acta Societatis Botanicorum Poloniae, 2014
After prolonged (3-9 weeks) hydroponic treatment of Scots pine seedlings with different concentrations (0.5-4.0 mM) of Al (AI(N03)3), the levels of pyridine nucleotides were determined in root homogenates.
Gabriela Lorenc-Plucińska, Piotr Karolewski   +1 more
doaj   +1 more source

Spinal SIRT1 activation attenuates neuropathic pain in mice. [PDF]

PLoS ONE, 2014
Abnormal histone acetylation occurs during neuropathic pain through an epigenetic mechanism. Silent information regulator 1 (sir2 or SIRT1), a NAD-dependent deacetylase, plays complex systemic roles in a variety of processes through deacetylating ...
Haijun Shao, Qingsheng Xue, Fujun Zhang, Yan Luo, Hao Zhu, Xiaoqing Zhang, Honghai Zhang, Wenlong Ding, Buwei Yu   +8 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

CD38 downregulation modulates NAD+ and NADP(H) levels in thermogenic adipose tissues

, 2021
Different strategies to boost NAD+ levels are considered promising means to promote healthy aging and ameliorate dysfunctional metabolism. CD38 is a NAD+-dependent enzyme involved in the regulation of different cell functions.
Emionite L., Zocchi E., De Flora A., Magnone M., Heeren J., Bruzzone S., Spinelli S., Fenoglio D., Benzi A., Parodi A., Heine M., Sociali G., Fischer A. W., Mittrucker H. -W., Koch-Nolte F., Sturla L., Guse A. H.   +16 more
core   +1 more source

The origins of management accounting in Italy. Analysis of the case study of the Ferrovie Nord Milano.

, 2002
This paper investigates the Italian contribution to the development of management accounting. The old tradition of Italian accounting studies is known all over the world.
ROFFIA, Paolo
core   +1 more source

NAMPT-mediated salvage synthesis of NAD+ controls morphofunctional changes of macrophages. [PDF]

PLoS ONE, 2014
Functional morphodynamic behavior of differentiated macrophages is strongly controlled by actin cytoskeleton rearrangements, a process in which also metabolic cofactors ATP and NAD(H) (i.e. NAD+ and NADH) and NADP(H) (i.e.
Gerda Venter, Frank T J J Oerlemans, Marieke Willemse, Mietske Wijers, Jack A M Fransen, Bé Wieringa   +5 more
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Sensitive superoxide detection in vascular cells by the new chemiluminescence dye L-012 [PDF]

, 1999
The detection superoxide production in vascular cells is usually limited by a low sensitivity of available assays, We tested the applicability of the luminol derivate L-012 {[}8-amino-5-chloro-7-phenylpyridol{[}3,4-d]pyridazine-l,4(2H,3H)dione] to ...
Sohn, Hae-Young, Gloe, Torsten, Pohl, Ulrich, Keller, Matthias, Schoenafinger, Karl   +4 more
core   +1 more source

Synthesis, Biological, and Computational Evaluations of Conformationally Restricted NAD-Mimics as Discriminant Inhibitors of Human NMN-Adenylyltransferase Isozymes

Pharmaceuticals
Nicotinamide adenine dinucleotide (NAD) cofactor metabolism plays a significant role in cancer development. Tumor cells have an increased demand for NAD and ATP to support rapid growth and proliferation.
Federica Matteucci, Marta Ferrati, Eleonora Spinozzi, Alessia Piergentili, Fabio Del Bello, Gianfabio Giorgioni, Leonardo Sorci, Riccardo Petrelli, Loredana Cappellacci   +8 more
doaj   +1 more source

Nicotinamide pre-treatment ameliorates NAD(H) hyperoxidation and improves neuronal function after severe hypoxia

Neurobiology of Disease, 2014
Prolonged hypoxia leads to irreversible loss of neuronal function and metabolic impairment of nicotinamide adenine dinucleotide recycling (between NAD+ and NADH) immediately after reoxygenation, resulting in NADH hyperoxidation.
Pavan K. Shetty, Francesca Galeffi, Dennis A. Turner   +2 more
doaj   +1 more source