Results 71 to 80 of about 158,023 (302)

Spinal SIRT1 activation attenuates neuropathic pain in mice. [PDF]

PLoS ONE, 2014
Abnormal histone acetylation occurs during neuropathic pain through an epigenetic mechanism. Silent information regulator 1 (sir2 or SIRT1), a NAD-dependent deacetylase, plays complex systemic roles in a variety of processes through deacetylating ...
Haijun Shao, Qingsheng Xue, Fujun Zhang, Yan Luo, Hao Zhu, Xiaoqing Zhang, Honghai Zhang, Wenlong Ding, Buwei Yu   +8 more
doaj   +1 more source

Untreated organoids contain cells with high levels of NAD(P)H intensity and cells with low levels of NAD(P)H intensity.

, 2017
(A) A representative fluorescence intensity image shows organoids with two levels of NAD(P)H intensity. (B) Low NAD(P)H cells exhibit a lower optical redox ratio than high NAD(P)H cells.
Melissa C. Skala (530309), Amy T. Shah (530305), Tiffany M. Heaster (3666343)   +2 more
core   +1 more source

Supporting Survivor‐Centered Care Through Digital Health Integration

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Survivors of childhood cancer face barriers to receiving guideline‐based, long‐term follow‐up care. Two digital tools, Passport for Care (PFC) and Cancer SurvivorLink (SurvivorLink), address complementary gaps by enabling tailored survivorship care plan (SCP) generation, updating, storage, and sharing.
Jordan G. Marchak, Rebecca Williamson‐Lewis, Michael O'Connor, Michael Palgon, Yu‐Ra Kim, Michael Schuckenbrock, Paula Edwards, Abraham Mendoza, Anthony Adams, Brian Arriaga‐Solis, Justin Parker, Harry Tinoco‐Giraldo, Jason King, C. Michael Fordis, Karen E. Effinger, Maria Monica Gramatges   +15 more
wiley   +1 more source

Synthesis, Biological, and Computational Evaluations of Conformationally Restricted NAD-Mimics as Discriminant Inhibitors of Human NMN-Adenylyltransferase Isozymes

Pharmaceuticals
Nicotinamide adenine dinucleotide (NAD) cofactor metabolism plays a significant role in cancer development. Tumor cells have an increased demand for NAD and ATP to support rapid growth and proliferation.
Federica Matteucci, Marta Ferrati, Eleonora Spinozzi, Alessia Piergentili, Fabio Del Bello, Gianfabio Giorgioni, Leonardo Sorci, Riccardo Petrelli, Loredana Cappellacci   +8 more
doaj   +1 more source

NAMPT-mediated salvage synthesis of NAD+ controls morphofunctional changes of macrophages. [PDF]

PLoS ONE, 2014
Functional morphodynamic behavior of differentiated macrophages is strongly controlled by actin cytoskeleton rearrangements, a process in which also metabolic cofactors ATP and NAD(H) (i.e. NAD+ and NADH) and NADP(H) (i.e.
Gerda Venter, Frank T J J Oerlemans, Marieke Willemse, Mietske Wijers, Jack A M Fransen, Bé Wieringa   +5 more
doaj   +1 more source

NQO1 (NAD(P)H dehydrogenase, quinone 1) [PDF]

, 2004
Review on NQO1 (NAD(P)H dehydrogenase, quinone 1), with data on DNA, on the protein encoded, and where the gene is ...
Ross, D
core   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Nicotinamide pre-treatment ameliorates NAD(H) hyperoxidation and improves neuronal function after severe hypoxia

Neurobiology of Disease, 2014
Prolonged hypoxia leads to irreversible loss of neuronal function and metabolic impairment of nicotinamide adenine dinucleotide recycling (between NAD+ and NADH) immediately after reoxygenation, resulting in NADH hyperoxidation.
Pavan K. Shetty, Francesca Galeffi, Dennis A. Turner   +2 more
doaj   +1 more source

Construction of an Alternative NAD+ De Novo Biosynthesis Pathway

Advanced Science, 2021
Nicotinamide adenine dinucleotide (NAD+) is a life essential molecule involved in versatile biological processes. To date, only two de novo biosynthetic routes to NAD+ are described, both of which start from a proteinogenic amino acid and are tightly ...
Yong Ding, Xinli Li, Geoff P. Horsman, Pengwei Li, Min Wang, Jine Li, Zhilong Zhang, Weifeng Liu, Bian Wu, Yong Tao, Yihua Chen   +10 more
doaj   +1 more source

Physiologische und strukturelle Untersuchungen zur Redoxmodulation, Aggregation/Dissoziation und Coenzymspezifität der NAD(P)(H)-Glycerinaldehyd-3-Phosphat Dehydrogenase [PDF]

, 2004
Die in dieser Arbeit durchgeführten Untersuchungen dienten dazu, die Eigenschaften und Grundlagen zur Regulation der chloroplastidären NAD(P)(H)-GAPDH im Wechsel zwischen Licht- und Dunkelmetabolismus aufzuklären.
Baalmann, Elisabeth
core