Results 111 to 120 of about 139,842 (299)

SIRT1 Activity Is Linked to Its Brain Region-Specific Phosphorylation and Is Impaired in Huntington’s Disease Mice [PDF]

, 2015
Huntingtons disease (HD) is a neurodegenerative disorder for which there are no disease-modifying treatments. SIRT1 is a NAD+-dependent protein deacetylase that is implicated in maintaining neuronal health during development, differentiation and ageing ...
Bates, GP, Benjamin, AC, Carnemolla, A, Chini, EN, Jolinon, N, Smith, DL, Tulino, R   +6 more
core   +1 more source

Pigeon‐Liver NAD Kinase [PDF]

European Journal of Biochemistry, 1975
NAD kinase was purified from pigeon liver by an improved procedure which included chromatography on phosphocellulose. The resultant preparation was homogeneous as judged by gel electrophoresis, but electrofocusing gave indications of heterogeneity. The enzyme appeared to be of molecular weight 270000, and to consist of subunits of molecular weight ...
openaire   +2 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease [PDF]

, 2011
Chronic obstructive pulmonary disease (COPD) is a global health problem, and current therapy for COPD is poorly effective and the mainstays of pharmacotherapy are bronchodilators.
Adenuga, Adenuga, Adenuga, Adenuga, Algood, Allison, Andersson, Andre, Anest, Arunachalam, Bannister, Barnes, Beeh, Bertolotti, Bessac, Biswal, Blake, Borchers, Borchers, Borchers, Bowie, Bracke, Caito, Caito, Calabrese, Capelli, Carrero, Carrozza, Celedon, Chen, Chen, Chen, Chen, Chen, Cheung, Cho, Christman, Church, Combadiere, Combadiere, Cosio, Costa, Csiszar, Cullinan, Cullinan, Dahl, De Boer, De Boer, de Boer, De Boer, de Ruijter, Decramer, Dekhuijzen, Dentener, Di Stefano, Dinarello, Donnelly, Duran, Edirisinghe, El Moussaoui, Facchinetti, Feghali-Bostwick, Ferrer, Foronjy, Franciosi, Furukawa, Galasinski, Ganguly, Gargalovic, Georgiou, Ghosh, Gongora, Goven, Gracie, Grumelli, Hardaker, Harding, Harju, Harju, Harrison, He, Hengstermann, Hogg, Hogg, Hongwei Yao, Hoshino, Hoshino, Hoshino, Hung, Hwang, Ichinose, Igishi, Iizuka, Imaoka, Imhof, Irfan Rahman, Ishii, Ito, Ito, Ito, Ito, Jorgensen, Juul, Kamei, Kang, Kang, Kasahara, Kassim, Kawahara, Keatings, Keatings, Kelsen, Kim, Kinnula, Kode, Kucukaycan, Lee, Lee, Lee, Leitges, Liu, Lukacs, Luo, Macnee, MacNee, Mahler, Mak, Malhotra, Mattagajasingh, McComb, Meja, Michaud, Michishita, Milne, Milne, Miotto, Mojtahedi, Moretti, Morrison, Motz, Murooka, Nakamaru, Nan, Netea, Niess, Ning, Nisoli, Nozik-Grayck, Ota, Ota, Pantano, Park, Pesci, Petersen, Petrache, Pinamonti, Porter, Potente, Potente, Rabe, Rahman, Rahman, Rahman, Rahman, Rajendrasozhan, Rajendrasozhan, Rangasamy, Rennard, Repine, Ryter, Rytila, Saetta, Saha, Saha, Sandford, Scherz-Shouval, Scherz-Shouval, Senftleben, Sengupta, Sethi, Sethi, Shapiro, Siedlinski, Simon, Singh, Siva, Sizemore, Soler, Sullivan, Sussan, Suzuki, Thatcher, Thomson, Tomaki, Traves, Trevisani, Tsoumakidou, Tuder, Turato, van der Pouw Kraan, van der Strate, van der Vlies, Van Gool, van Overveld, Vaziri, Vermeulen, Vlahos, Wang, Widdowson, Wright, Wright, Xiao, Yagi, Yamamoto, Yamato, Yang, Yang, Yang, Yang, Yang, Yang, Yao, Yao, Yao, Yao, Yin, Young, Zhang, Zhang, Zheng, Zochbauer-Muller   +230 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Acute Ethanol Intake Induces NAD(P)H Oxidase Activation and Rhoa Translocation in Resistance Arteries

Arquivos Brasileiros de Cardiologia
Background: The mechanism underlying the vascular dysfunction induced by ethanol is not totally understood. Identification of biochemical/molecular mechanisms that could explain such effects is warranted.
Janaina A. Simplicio, Ulisses Vilela Hipólito, Gabriel Tavares do Vale, Glaucia Elena Callera, Camila André Pereira, Rhian M Touyz, Rita de Cássia Tostes, Carlos R. Tirapelli   +7 more
doaj   +1 more source

Incorporating expression data in metabolic modeling: a case study of lactate dehydrogenase

, 2005
Integrating biological information from different sources to understand cellular processes is an important problem in systems biology. We use data from mRNA expression arrays and chemical kinetics to formulate a metabolic model relevant to K562 ...
Akesson, Baker, Barkai, Borgmann, Dang, Fan, Ferea, Goodacre, Griffiths, Gross, Joel R. Sevinsky, Joshua Downer, Jungmann, Kal, Karan, Katheryn A. Resing, Kim, Kitano, Kondoh, Koslowski, Koukourakis, Lambeth, Lewis, Lewis, Li, M.D. Betterton, Maekawa, Mazurek, Mulquiney, Munoz-Pinedo, Natalie G. Ahn, Newell, Osthus, Papas, Press, Riera, Segal, Sevinsky, Shim, Stambaugh, Stephanopoulos, Stubbs, Tilton, Unwin, Voet, von Dassow, Walenta, Warburg   +47 more
core   +1 more source

PARP-3 and APLF function together to accelerate nonhomologous end joining [PDF]

, 2010
PARP-3 is a member of the ADP-ribosyl transferase superfamily of unknown function. We show that PARP-3 is stimulated by DNA double-strand breaks (DSBs) in vitro and functions in the same pathway as the poly (ADP-ribose)-binding protein APLF to accelerate
Ahel, Ame, Anna E.O. Fisher, Audebert, Bekker-Jensen, Benjamin, Bernardo Reina-San-Martin, Boulton, Brown, Bryant, Bryant, Caldecott, Caldecott, Critchlow, Ding, Drouet, El-Khamisy, Farmer, Fisher, Grawunder, Guy Poirier, Hochegger, Hottiger, Iles, Isabelle Robert, Kanno, Keith W. Caldecott, Kickhoefer, Kleine, Le Page, Lehtio, Limei Ju, Lobrich, Loseva, Macrae, Mahaney, Maria C. Zuma, Mehrotra, Michele Rouleau, Morrison, Okano, Otto, Poirier, Robert, Roberts, Rogakou, Rogakou, Rouleau, Rulten, Smith, Soulas-Sprauel, Stevnsner, Stuart L. Rulten, Sugimura, Trucco, Wang, Yan, Yang, Yano, Yano   +59 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Epigenetics and immunometabolism in diabetes and aging [PDF]

, 2018
Significance: A strong relationship between hyperglycemia, impaired insulin pathway and cardiovascular disease in type 2 diabetes (T2D) is linked to oxidative stress and inflammation.
Cosentino, Francesco, Guzik, Tomasz J.
core   +2 more sources