Results 131 to 140 of about 741,550 (282)

Structure-based design, synthesis and biological evaluation of a NAD⁺ analogue targeting Pseudomonas aeruginosa NAD kinase. [PDF]

FEBS J, 2023
Rahimova R, Nogaret P, Huteau V, Gelin M, Clément DA, Labesse G, Pochet S, Blanc-Potard AB, Lionne C.   +8 more
europepmc   +1 more source

Nicotinamide Riboside: A Promising Treatment for Type 1 Cardiorenal Syndrome in Myocardial Infarction‐Induced Acute Kidney Injury by Upregulating Nicotinamide Phosphoribosyltransferase‐Mediated Nicotinamide Dinucleotide Levels

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Cardiorenal syndrome type 1 is characterized by the development of acute kidney injury following acute cardiac illness and notably acute myocardial infarction (MI).
Nada J. Habeichi, Ghadir Amin, Solene Boitard, Cynthia Tannous, Rana Ghali, Iman Momken, Reine Diab, George W. Booz, Mathias Mericskay, Fouad A. Zouein   +9 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

8-Thioalkyl-adenosine derivatives inhibit Listeria monocytogenes NAD kinase through a novel binding mode

, 2016
Increased resistance of pathogens to existing antibiotics necessitates the search for novel targets to develop potent antimicrobials. Biosynthetic pathways of several cofactors important for bacterial growth, such as nicotinamide adenine dinucleotide ...
Nahori, Marie -Anne, Labesse, Gilles, Paoletti, Julie, Gelin, Muriel, Dussurget, Olivier, Huteau, Valerie, Pochet, Sylvie, Assairi, Liliane   +7 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Cytoplasmic NAD/H synthesis via NRK1 regulates inflammatory capacity and promotes survival of CD4+ T cells

Nature Communications
T cell metabolism increases upon activation, underpinning immune effector functions. Nicotinamide adenine dinucleotide (NAD/H) is an essential redox cofactor for glycolysis and mitochondrial substrate oxidation.
Victoria Stavrou, Myah Ali, Nancy Gudgeon, Emma L. Bishop, Taylor Fulton-Ward, Bethany Turley, Silke Heising, Sally H. Mohamed, Sofia Hain, Lorna George, Minghao Deng, Jack McCowan, Lozan Sheriff, Scott P. Davies, Bryan Marzullo, Daniel A. Tennant, Craig L. Doig, David A. Bending, Ed W. Roberts, Gareth G. Lavery, Rebecca A. Drummond, Sarah Dimeloe   +21 more
doaj   +1 more source

NMRK2–YAP–NADK axis preserves redox protection against myocardial ischemia/reperfusion injury

Redox Biology
Substantial oxidative stress during myocardial ischemia/reperfusion (I/R) injury precipitates cell death and heart failure, for which translatable redox therapies remain scarce.
Chao Zhang, Jie Wang, Jing Chi, Su-ting Liu, Xiao-wen Meng, Lin-gui Li, Shunli Dong, Hui Cao, Xing-gen Zhou, Yang Zhang, Hai-yan Sun, Pei-pei Kang, Ke Peng, Fu-hai Ji   +13 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

LncRNA like NMRK2 mRNA functions as a key molecular scaffold to enhance mitochondrial respiration of NONO-TFE3 rearranged renal cell carcinoma in an NAD⁺ kinase-independent manner. [PDF]

J Exp Clin Cancer Res, 2023
Chen Y, Lu Y, Yang L, Ma W, Dong Y, Zhou S, Liu N, Gan W, Li D.   +8 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source