Results 121 to 130 of about 1,176,786 (313)

Redox Profiling of NAD Kinase in Acute Kidney Injury

, 2023
Title: Redox Profiling of NAD Kinase in Acute Kidney Injury Authors: Emily Q. Quach Pharm.D. Candidate 2023, Liang-Jun Yan PhD. Abstract Background: Acute kidney injury (AKI) is a common clinical disorder in hospitalized patients and is characterized ...
Quach, Emily, Yan, Liang-Jun
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Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Detoxification of succinate semialdehyde in Arabidopsis glyoxylate reductase and NAD kinase mutants subjected to submergence stress

, 2012
Succinate semialdehyde (SSA) is a mitochondrially generated intermediate in the metabolism of γ-aminobutyrate (GABA), which accumulates in response to a variety of biotic and abiotic stresses.
Amanda Rochon, Barry J. Shelp, Wolyn, DJ, Wendy L. Allan, Snedden, WA, Jeffrey P. Simpson, Gordon J. Hoover, Wayne A. Snedden, Breitkreuz, KE, Rentsch, D, Rochon, A, David J. Wolyn, Waller, JC, Simpson, JP, Hoover, GJ, Shelp, BJ, Jeffrey C. Waller, Doris Rentsch, Kevin E. Breitkreuz, Allan, WL   +19 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Tailoring Targeted Therapy to Individual Patients: Lessons to be Learnt from the Development of Mitomycin C

, 2007
The modern era of targeted therapeutics offers the potential to tailor therapy to individual patients whose tumours express a specific target. Previous attempts to forecast tumour response to conventional chemotherapeutics based on similar principles ...
Phillips, Roger M, Volpato, Milene
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NAD kinase promotes Staphylococcus aureus pathogenesis by supporting production of virulence factors and protective enzymes. [PDF]

Elife, 2022
Leseigneur C, Boucontet L, Duchateau M, Pizarro-Cerda J, Matondo M, Colucci-Guyon E, Dussurget O.   +6 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Protein kinase C epsilon regulates mitochondrial pools of Nampt and NAD following resveratrol and ischemic preconditioning in the rat cortex

, 2014
Preserving mitochondrial pools of nicotinamide adenine dinucleotide (NAD) or nicotinamide phosphoribosyltransferase (Nampt), an enzyme involved in NAD production, maintains mitochondrial function and confers neuroprotection after ischemic stress. However,
Morris-Blanco, Kahlilia C, Sick, Thomas J, Perez-Pinzon, Miguel A, Cohan, Charles H, Neumann, Jake T   +4 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

La NAD kinase du latex d'Hevea brasiliensis caractérisation et purification

, 1988
Une activité NAD kinase (EC 2.7.1.23) a été mise en évidence dans le latex d'Hevea brasiliensis. Elle est localisée dans la fraction lourde du latex centrifugé et est probablement liée, soit aux membranes des lutoïdes, soit à d'autres structures ...
Chrestin, H., Niamien N'Goran, M., Lorquin, Jean   +2 more
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