Results 51 to 60 of about 8,969 (152)

Oxidative Stress and DNA Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Reactive oxygen species (ROS) modulate DNA methyltransferases (DNMTs), ten‐eleven translocation family proteins (TETs) and their cofactors, reshaping 5‐methylcytosine (5mC)/5‐hydroxymethylcytosine (5hmC)/5‐formylcytosine (5fC) landscapes and gene expression in cancer cells. In turn, epigenetic control of antioxidant and metabolic pathways feeds back on
Xishan Yang, Qitai Chen, YuJie Yu, Yi Zang, Rujia Zheng, Zhe Zhang, Shuaijun Lu, Li Zhou   +7 more
wiley   +1 more source

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

Sugar metabolism, redox balance and oxidative stress response in the respiratory yeast [PDF]

, 2009
A lot of studies have been carried out on Saccharomyces cerevisiae, an yeast with a predominant fermentative metabolism under aerobic conditions, which allows exploring the complex response induced by oxidative stress. S.
M Isabel González-Siso, Ana García-Leiro, Nuria Tarrío, M Esperanza Cerdán   +3 more
core   +1 more source

Synthesis of Amines for Active Pharmaceutical Ingredients Using the Whole‐Cell Factory Saccharomyces Cerevisae

ChemBioChem, Volume 27, Issue 9, 14 May 2026.
This review highlights advances in engineering Saccharomyces cerevisiae for the sustainable biocatalytic production of pharmaceutically relevant amines, amino alcohols, amino acids, and complex alkaloids. It focuses on strategies to increase productivity, including enhanced enzyme expression, cofactor regeneration, precursor channeling, pathway ...
Natalia Kwiatos, Stephen Ossel, Francesco G. Mutti   +2 more
wiley   +1 more source

Electron Transfer Pathways and Dynamics of Chloroplast NADPH-dependent Thioredoxin Reductase C (NTRC) [PDF]

, 2012
NADPH-dependent thioredoxin reductases (NTRs) contain a flavin cofactor and a disulfide as redox-active groups. The catalytic mechanism of standard NTR involves a large conformational change between two configurations.
Bernal Bayard, Pilar, Cejudo Fernández, Francisco Javier, Hervás Morón, Manuel, Navarro Carruesco, José Antonio   +3 more
core   +1 more source

Substrate Walking for Selective Ene Reduction

ChemCatChem, Volume 18, Issue 9, 14 May 2026.
Ene‐reductases (EREDs) efficiently reduce activated C═C bonds. Expanding the current application, they catalyze the selective reduction of highly substituted cyclohexenones. Immobilized, they were scaled to 200 mL, achieving full substrate conversion without enzyme degradation. ABSTRACT Ene‐reductases (EREDs) efficiently reduce activated C═C bonds, but
Hugo Brasselet, Jonathan Berger, Elisa Arends, Adriaan de Man, Laura van der Weel, Hessel van Dijk, Anke Hummel, Harald Gröger, Ulf Hanefeld   +8 more
wiley   +1 more source

Expression and purification of the recombinant subunits of toluene/o-xylene monooxygenase and reconstitution of the active complex. [PDF]

, 2002
This paper describes the cloning of the genes coding for each component of the complex of toluene/o-xylene monooxygenase from Pseudomonas stutzeri OX1, their expression, purification and characterization.
Amoresano, A, Cafaro, V, Casbarra, A, DAL PIAZ, F, Di Donato, A., Izzo, V, Notomista, E, Passaro, I, Pucci, P., Scognamiglio, R, Viggiani, A   +10 more
core   +1 more source

Emerging Technologies for Biobutanol Production via Syngas Fermentation

GCB Bioenergy, Volume 18, Issue 5, May 2026.
Biobutanol production from syngas is promising but limited by microbial energy conservation and gas–liquid mass transfer. This review integrates advances in cultivation control and bioreactor engineering with next‐generation biological tools including metabolic rewiring, co‐cultivation and chain elongation, and electro‐fermentation to enable carbon ...
Xuemei Wang, Luiza C. Campos, Zifu Li, Werner Fuchs   +3 more
wiley   +1 more source

Identification of nucleoid associated proteins (NAPs) under oxidative stress in Staphylococcus aureus [PDF]

, 2017
BackgroundBacterial nucleoid consists of genome DNA, RNA, and hundreds of nucleoid-associated proteins (NAPs). Escherichia coli nucleoid is compacted towards the stationary phase, replacing most log-phase NAPs with the major stationary-phase nucleoid ...
Morikawa Kazuya, Ohniwa Ryosuke L., Ushijima Yuri, 大庭 良介, 森川 一也   +4 more
core   +1 more source

Prenylcysteine Oxidase 1 Deficiency Protects the Cardiac Muscle Cell Line HL‐1 Against Ischaemic/Hypoxic Stress

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Ischaemic/hypoxic stress leads to heart remodeling and dysfunction. PCYOX1 promotes cardiomyocyte survival during injury, reducing the generation of reactive oxygen species. PCYOX1 deficiency regulates key proteins to preserve cardiomyocyte structure and function such as creatine kinase.
Cristina Banfi, Lisa Brocca, Alice Bascucci, Giulia Giusy Papaianni, Alice Mallia, Sonia Eligini   +5 more
wiley   +1 more source