Results 91 to 100 of about 268,882 (295)

CDK1-mediated phosphorylation of LDHA fuels mitosis through LDHB-dependent lactate oxidation

EMBO Reports
While cancer cells overexpress lactate dehydrogenase A (LDHA) to support glycolytic flux and lactate production, the role of LDHB—which preferentially catalyzes lactate oxidation—remains unclear. Here, we demonstrate that LDHB, but not LDHA, is essential
Mengting Liu, Aoxing Cheng, Weiyi You, Jiaxin Wu, Chenxu Dai, Ting Wang, Ying Wu, Fumei Zhong, Jue Shi, Yingying Du, Zhonghuai Hou, Ping Gao, Ke Ruan, Yi Yang, Yuzheng Zhao, Kaiguang Zhang, Zhenye Yang, Jing Guo   +17 more
doaj   +1 more source

Central Nervous System Proteomics in Animal Model of Multiple Sclerosis Revealed Down-Regulation of Mithochondrial Proteins [PDF]

Cell Journal, 2009
Objective: Detection of central nervous system (CNS) molecular defects in an animal modelof multiple sclerosis.Materials and Methods: Experimental autoimmune encephalomyelitis (EAE) was inducedby a myelin oligodendrocyte glycoprotein.
Abolhassan Shahzadeh Fazeli, Mohammad Hossein Sanati, Davood Nasrabadi, Alireza Pouya, Hossein Baharvand, Ghasem Hosseini Salekdeh   +5 more
doaj  

AARS2‐SIRT5‐Driven DLD K445 Lactylation Promotes Cuproptosis Resistance in Glioblastoma Stem Cells

Advanced Science, EarlyView.
Lactylation of DLD at K445 by AARS2 suppresses PDH complex activity and reduces DLAT lipoylation, thereby conferring cuproptosis resistance in glioblastoma stem cells. SIRT5‐mediated delactylation restores PDH function and enhances cuproptosis sensitivity.
Mingtian Ding, Haibiao Xu, Cen Liu, Yangyin Ding, Shuai Wang, Jun Yin, Tao Fu, Xiao Jiang, Yuning Chen, Hui Luo, Rui Li, Zhengxin Chen, Huibo Wang   +12 more
wiley   +1 more source

Superoxide anion production by adriamycinol from cardiac sarcosomes and by mitochondrial NADH dehydrogenase

, 1986
This study investigates the effects of both adriamycin and its 13-hydroxylated metabolite adriamycinol on superoxide anion production from cardiac sarcosomes and by mitochondrial NADH dehydrogenase. Superoxide anion production was determined by using the
GERVASI PG, CITTI L, AGRILLO MR, DEL TACCA M., DANESI, ROMANO   +4 more
core   +2 more sources

L-BOAA induces selective inhibition of brain mitochondrial enzyme, NADH-dehydrogenase

, 1993
Lathyrism, a human neurological disorder has been linked to the excessive consumption of a plant toxin, β-oxalylamino-L-alanine (L-BOAA) present in Lathyrus sativus.
Pai, Karnie Sadashiva, Ravindranath, Vijayalakshmi   +1 more
core   +1 more source

H4K12 Lactylation Regulates NDUFS7 to Drive Microglia Reverse Electron Transport in Spinal Cord Injury

Advanced Science, EarlyView.
Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong, Zhichen Jiang, Zhouwei Wu, Chenyu Wu, Jiang Liu, Kaijie Guo, Yihui Liang, Shaobo Xu, Yuchen Jin, Yong Xiao, Lei Guo, Hui Xu, Sunren Sheng, Chenggui Wang   +13 more
wiley   +1 more source

Flavoprotein-mediated tellurite reduction: structural basis and applications to the synthesis of tellurium-containing nanostructures

Frontiers in Microbiology, 2016
The tellurium oxyanion tellurite (TeO32-) is extremely harmful for most organisms. It has been suggested that a potential bacterial tellurite resistance mechanism would consist of an enzymatic, NAD(P)H-dependent, reduction to the less toxic form ...
Mauricio Arenas-Salinas, Joaquín Ignacio Vargas, Wladimir Morales, Camilo Pinto, Pablo Muñoz, Fabian Alexis Cornejo, Benoit Pugin, Juan Sandoval, Waldo Diaz, Claudia Muñoz-Villagrán, Fernanda Jimena Rodríguez, Eduardo Morales, Claudio Christian Vásquez, Felipe Arenas   +13 more
doaj   +1 more source

NADH Electrochemical Sensor Coupled with Dehydrogenase Enzymes

Analytical Letters, 1992
Abstract A graphite electrode assembled in a flow cell has shown to be a good detector for NADH. Current is linearly dependent on concentration in the range 10−7 -10−3 M without any mediator at the potential applied of 300 mV vs Ag/AgCl. Lactate and alcohol dehydrogenases were immobilized near to the electrode surface or in a reactor to obtain an NADH ...
Yamanaka, Hideko, Mascini, Marco
openaire   +2 more sources

Metabolic Signatures for Liver Cancer Diagnosis and Mechanistic Insights: A Large‐Scale, Multicenter Study

Advanced Science, EarlyView.
A large‐scale multicenter serum metabolomics study (13 centers, n = 2,149) identified a 9‐metabolite + AFP diagnostic signature for liver cancer (AUC = 0.93). Among the signature, nicotinamide (NAM) was validated as an oncometabolite: NAM enhances NAD+ synthesis, activating SIRT1 to deacetylate and stabilize HIF1α, thereby driving glycolysis, MAPK ...
Yongjie Xu, Jiachen Wang, Chunmeng Ding, Changfa Xia, Yunyong Liu, Yuanjie Zheng, Sheng Chang, Shaokai Zhang, Yutong He, Ruifang Sun, Yunfeng Xi, Yan Liu, Kun Qian, Wanqing Chen   +13 more
wiley   +1 more source

Enzyme-dependent fluorescence recovery of NADH after photobleaching to assess dehydrogenase activity of isolated perfused hearts. [PDF]

, 2017
Reduction of NAD(+) by dehydrogenase enzymes to form NADH is a key component of cellular metabolism. In cellular preparations and isolated mitochondria suspensions, enzyme-dependent fluorescence recovery after photobleaching (ED-FRAP) of NADH has been ...
Kuzmiak-Glancy, Sarah, Matthew W. Kay, Rafael Jaimes, Moreno, Angel, Jaimes, Rafael, Angel Moreno, Kay, Matthew W, Sarah Kuzmiak-Glancy   +7 more
core   +1 more source