Results 101 to 110 of about 465,834 (342)

CDK1-mediated phosphorylation of LDHA fuels mitosis through LDHB-dependent lactate oxidation

EMBO Reports
While cancer cells overexpress lactate dehydrogenase A (LDHA) to support glycolytic flux and lactate production, the role of LDHB—which preferentially catalyzes lactate oxidation—remains unclear. Here, we demonstrate that LDHB, but not LDHA, is essential
Mengting Liu, Aoxing Cheng, Weiyi You, Jiaxin Wu, Chenxu Dai, Ting Wang, Ying Wu, Fumei Zhong, Jue Shi, Yingying Du, Zhonghuai Hou, Ping Gao, Ke Ruan, Yi Yang, Yuzheng Zhao, Kaiguang Zhang, Zhenye Yang, Jing Guo   +17 more
doaj   +1 more source

Redox engineering of thermophilic fungus Myceliophthora thermophila enhances production of L‑malic acid by consolidated bioprocessing

Mycology
Consolidated bioprocessing (CBP) is a promising strategy for low-cost malic acid production from plant biomass. In this study, we report a comprehensive redox engineering strategy to redirect reducing equivalents towards the reductive tricarboxylic acid (
Yuying Zhang, Rui Fan, Taju Wu, Shuying Gu, Defei Liu, Liangcai Lin, Min Wang, Jingen Li, Chaoguang Tian   +8 more
doaj   +1 more source

Central Nervous System Proteomics in Animal Model of Multiple Sclerosis Revealed Down-Regulation of Mithochondrial Proteins [PDF]

Cell Journal, 2009
Objective: Detection of central nervous system (CNS) molecular defects in an animal modelof multiple sclerosis.Materials and Methods: Experimental autoimmune encephalomyelitis (EAE) was inducedby a myelin oligodendrocyte glycoprotein.
Abolhassan Shahzadeh Fazeli, Mohammad Hossein Sanati, Davood Nasrabadi, Alireza Pouya, Hossein Baharvand, Ghasem Hosseini Salekdeh   +5 more
doaj  

The Type I NADH Dehydrogenase of Mycobacterium tuberculosis Counters Phagosomal NOX2 Activity to Inhibit TNF-α-Mediated Host Cell Apoptosis

PLoS Pathogens, 2010
The capacity of infected cells to undergo apoptosis upon insult with a pathogen is an ancient innate immune defense mechanism. Consequently, the ability of persisting, intracellular pathogens such as the human pathogen Mycobacterium tuberculosis (Mtb) to
Jessica L. Miller, Kamalakannan Velmurugan, M. Cowan, V. Briken   +3 more
semanticscholar   +1 more source

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source

NADH Electrochemical Sensor Coupled with Dehydrogenase Enzymes

Analytical Letters, 1992
Abstract A graphite electrode assembled in a flow cell has shown to be a good detector for NADH. Current is linearly dependent on concentration in the range 10−7 -10−3 M without any mediator at the potential applied of 300 mV vs Ag/AgCl. Lactate and alcohol dehydrogenases were immobilized near to the electrode surface or in a reactor to obtain an NADH ...
Yamanaka, Hideko, Mascini, Marco
openaire   +2 more sources

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

Flavoprotein-mediated tellurite reduction: structural basis and applications to the synthesis of tellurium-containing nanostructures

Frontiers in Microbiology, 2016
The tellurium oxyanion tellurite (TeO32-) is extremely harmful for most organisms. It has been suggested that a potential bacterial tellurite resistance mechanism would consist of an enzymatic, NAD(P)H-dependent, reduction to the less toxic form ...
Mauricio Arenas-Salinas, Joaquín Ignacio Vargas, Wladimir Morales, Camilo Pinto, Pablo Muñoz, Fabian Alexis Cornejo, Benoit Pugin, Juan Sandoval, Waldo Diaz, Claudia Muñoz-Villagrán, Fernanda Jimena Rodríguez, Eduardo Morales, Claudio Christian Vásquez, Felipe Arenas   +13 more
doaj   +1 more source

Aerobic nitrogen fixation in Azotobacter vinelandii

, 1977
I ELECTRON DONATION TO NITROGENASEPaper I shows that the hypothesis, that a high ratio of (NADH + NADPH) / (NAD + + NADP + ) is the source of reducing power for nitrogenase in intact A.vinelandii, is invalid.
Haaker, H.B.C.M.
core  

Reactions for NADH dehydrogenase and Quinolinate synthase.

Reactions for NADH dehydrogenase and Quinolinate synthase.
Ke Chen (73307), Bernhard O. Palsson (91399), Jiao Zhao (92360), Laurence Yang (3440912)   +3 more
core   +1 more source