Results 111 to 120 of about 1,174 (166)

Supplementary Table 11 from NUAK1-Mediated Phosphorylation of NADK Mitigates ROS Accumulation to Promote Osimertinib Resistance in Non–Small Cell Lung Carcinoma

<p>Supplementary Table 11 Detection of SNVs and CNVs in HCC827OR and PC9OR</p>
Yunchong Meng, Yongde Liao, Xiaojun Wang, Peiyuan Mei, Kuo Li, Quanfu Huang, Mingxin Diao, Shihao Wu, Na Wang, Wei Lin   +9 more
openaire   +1 more source

Case reports for the recessive disorder due to a mutation in mitochondrial NAD kinase gene (NADK2) [PDF]

, 2017
NADP＋は，主に補酵素として生体内の多様な合成系の反応や酸化ストレスからの防御反応等に関わる. NADP＋は，NAD キナーゼ(NADK)のはたらきによるNAD＋のリン酸化反応 (反応式1) により合成される. NAD＋＋ ATP → NADP＋＋ ADP (反応式1) ヒトでは，ミトコンドリア局在性NADK(NADK2)と細胞質局在性NADK が機能しており，特に前者のNADK2 は著者らにより特定された.
村田, 幸作, 河井, 重幸
core  

PROBING BINDING REQUIREMENTS OF NAD KINASE WITH MODIFIED NAD ANALOGUES

, 2012
NAD kinase (NADK) catalyzes a magnesium-dependent phosphorylation of the 2′-hydroxyl group of the adenosine ribose moiety of nicotinamide adenine dinucleotide (NAD) using ATP or inorganic polyphosphates as phosphoryl donors to give NADP.
Michele Di Stefano, Palmarisa Franchetti, Krzysztof W. Pankiewicz, CAPPELLACCI, Loredana, VITA, PATRIZIA, Mario Grifantini, Giulio Magni, PETRELLI, Riccardo, TORQUATI, ILARIA, Krzysztof Felczak   +9 more
core  

Collateral lethality of NAD kinase in 1p36 deleted tumors drives vulnerability to NAD kinase 2 depletion. [PDF]

BBA Adv
Suyama-Banjo S, Watanabe K, Ishikawa H, Yoshihama Y, Hirota Y, Tsutsumi S.   +5 more
europepmc   +1 more source

Nicotinamide metabolism-related signature and lncRNA regulatory network in kidney renal clear cell carcinoma. [PDF]

PeerJ
Dong P, Zhao L, Shi P, Ma M, Huang B, Wang Z, Zhang S, Liu H.   +7 more
europepmc   +1 more source

Identificação funcional e localização subcelular da NAD quinase no parasita protozoário Giardia intestinalis

, 2019
Nicotinamide adenine dinucleotide phosphate (NADP) is an essential biomolecule that participates in the redox homeostasis and synthesis of signaling compounds. NAD kinase (NADK) (EC 2.7.1.23/2.7.1.86) is the only enzyme capable of synthesizing NADP. This
García Castañeda, Javier Eduardo, Ramírez Hernández, María Helena, Jutinico Shubach, Laura Marcela, Contreras Rodríguez, Luis Ernesto   +3 more
core  

Synthesis of thermostable artificial nicotinamide cofactors: carba-NAD⁺ and carba-NADP^. [PDF]

RSC Chem Biol
Dsouza Z, Friedrichs JJ, Döring M, Rincón Téllez N, Schmermund L, Sieber V.   +5 more
europepmc   +1 more source

Kinase and phosphatase inhibition as a signal transduction-centric approach to adjunctive chemotherapies for the treatment of gynecologic cancers: DTYMK.

Men and women differ in large part resulting from the presence or absence of gynecologic organs including the ovaries, the uterus, the lining of which is known as the endometrium, and the entry to the uterus (womb), the cervix (1), all of which are targets for development of malignancies (2-7); vulvar cancer is less common (8).
openaire   +11 more sources

Oxidative Stress Induces the Phosphorylation of NAD⁺ to NADP⁺ by NAD Kinase in Cultured Primary Rat Astrocytes. [PDF]

Neurochem Res
Willker JE, Watermann P, Dringen R.
europepmc   +1 more source

Therapeutic targeting in breast cancer for the treatment of lymph node metastasis: MUTYH.

Metastasis is the major cause of death from cancer.  Metastasis to the lymph node (“regional” metastasis) generally precedes distant metastasis, and we recently demonstrated that metastasis to the lymph nodes is a likely prerequisite for metastasis to the central nervous system (CNS) in humans with breast cancer (1-8).
openaire   +31 more sources