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Optimized network inference for immune diseased single cells

Frontiers in Immunology
IntroductionMathematical models are powerful tools that can be used to advance our understanding of complex diseases. Autoimmune disorders such as systemic lupus erythematosus (SLE) are highly heterogeneous and require high-resolution mechanistic ...
Elena Merino Tejero +10 more
doaj +1 more source

Exogenous trehalose improves the survival of date palm suckers by enhancing thioredoxin-antioxidant systems activity

Plant Stress
Trehalose, a disaccharide, regulates osmotic pressure, stabilizes proteins, and plays in the signaling of carbon allocation in response to abiotic stresses.
Majid Alikhani-Koupaei, Morteza Soleimani Aghdam +1 more
doaj +1 more source

Inhibitory effect of lemon peel flavonoids on UVB induced skin damage in mice

All Life
This research investigated the protective potential of lemon peel flavonoids (LPF) against skin damage caused by ultraviolet B (UVB) radiation. Treatment with LPF markedly mitigated UVB-triggered skin injury in mice, preserving normal epidermal and ...
Xi Gao, Diru Xu, Yu Chen
doaj +1 more source

The NADK genes of extant eukaryotes originate from two ancient eukaryotic sister clades of uncertain provenance.

, 2019
Shown is a phylogenetic tree computed by Bayesian inference of NADK genes from the Bacteria (top clades), Eukarya (middle two clades labeled “mito” and cyto”), and the Archaea (bottom gold clade).
Albert Erives (269738), Oliver Vickman (7115075) +1 more
core +1 more source

8-Thioalkyl-adenosine derivatives inhibit Listeria monocytogenes NAD kinase through a novel binding mode

, 2016
Increased resistance of pathogens to existing antibiotics necessitates the search for novel targets to develop potent antimicrobials. Biosynthetic pathways of several cofactors important for bacterial growth, such as nicotinamide adenine dinucleotide ...
Nahori, Marie -Anne +7 more
core +1 more source

Native NAD-dependent GAPDH replaced with NADP-dependent GAPDH plus NADK

, 2012
This invention is metabolically engineer bacterial strains that provide increased intracellular NADPH availability for the purpose of increasing the yield and productivity of NADPH-dependent compounds.
Wang, Yipeng, Bennett, George N., San, Ka-Yiu +2 more
core

Abiotic/biotic stress and hormone response elements in AtNADK and OsNADK promoters^*.

, 2014
*the cis-elements were identified with the PlantCARE program (http://bioinformatics.psb.ugent.be/webtools/plantcare/html/) using the sequences 1500 bp upstream from the transcription start site of each NADK gene. The “√” means the NADK gene contains this
Ri Li (589196) +4 more
core +1 more source

A novel anti-oxidantive defense strategy aimed at converting NADH, a pro-oxidant, into NADPH, an anti-oxidant.

, 2013
MDH = malate dehydrogenase, ME = malic enzyme, PC = pyruvate carboxylase, and NADK = NAD kinase.
Ranji Singh (50823) +3 more
core +1 more source

Supplementary Data from NUAK1-Mediated Phosphorylation of NADK Mitigates ROS Accumulation to Promote Osimertinib Resistance in Non–Small Cell Lung Carcinoma

<p>Supplementary information</p>
Yunchong Meng +9 more
openaire +1 more source

Technology in Cancer Research & Treatment
Pyroptosis is a programmed cell death, which garners increasing attention by relating to immune and therapy response. However, the role of pyroptosis in colorectal cancer (CRC) remains unclear.
Linjing Li PhD +3 more
doaj +1 more source

nadph
gene expression
nad kinase