Results 81 to 90 of about 1,174 (166)

From Substrate to Fragments to Inhibitor Active In Vivo against Staphylococcus aureus

, 2020
Antibiotic resistance is a worldwide threat due to the decreasing supply of new antimicrobials. Novel targets and innovative strategies are urgently needed to generate pathbreaking drug compounds.
Muriel Gelin (2881670), David Clément (8452608), Julie Paoletti (8452596), Olivier Dussurget (141783), Liliane Assairi (2011171), Sylvie Pochet (486816), Valérie Huteau (8452599), Marie-Anne Nahori (211108), Jean-Luc Pons (6421430), Laurence Dugué (8452605), Grégory Jouvion (3108516), Gilles Labesse (19363), Clarisse Leseigneur (8452602)   +12 more
core   +1 more source

Conferring the ability to utilize inorganic polyphosphate on ATP-specific NAD kinase [PDF]

, 2013
ATP特異性の獲得メカニズムの解明 : 新薬と新しい物質生産系の開発に期待. 京都大学プレスリリース. 2013-09-11.NAD kinase (NADK) is a crucial enzyme for production of NADP(+). ATP-specific NADK prefers ATP to inorganic polyphosphate [poly(P)] as a phosphoryl donor, whereas poly(P)/ATP-NADK utilizes ...
Murata, Kousaku, Kawai, Shigeyuki, Yoshioka, Aya, Nakamichi, Yusuke   +3 more
core   +1 more source

An Exome-wide Association Study for Type 2 Diabetes–Attributed End-Stage Kidney Disease in African Americans

Kidney International Reports, 2018
Introduction: Compared with European Americans, African Americans (AAs) are at higher risk for developing end-stage kidney disease (ESKD). Genome-wide association studies (GWAS) have identified >70 genetic variants associated with kidney function and ...
Meijian Guan, Jacob M. Keaton, Latchezar Dimitrov, Pamela J. Hicks, Jianzhao Xu, Nicholette D. Palmer, James G. Wilson, Barry I. Freedman, Donald W. Bowden, Maggie C.Y. Ng   +9 more
doaj   +1 more source

NAD kinase : an original bacterial target for antibiotic development

, 2021
La résistance aux antibiotiques est en enjeu de santé publique majeur, requérant le développement de nouveaux antibiotiques et l'identification de nouvelles cibles bactériennes originales.
Leseigneur, Clarisse
core  

Homeostatic regulation of NAD(H) and NADP(H) in cells

Genes and Diseases
Nicotinamide adenine dinucleotide (NAD+)/reduced NAD+ (NADH) and nicotinamide adenine dinucleotide phosphate (NADP+)/reduced NADP+ (NADPH) are essential metabolites involved in multiple metabolic pathways and cellular processes.
Luojun Chen, Xiaoke Xing, Pingfeng Zhang, Lulu Chen, Huadong Pei   +4 more
doaj   +1 more source

Function of Pseudomonas fluorescens L5.1-96 proteins MPPE and NADK in wheat root colonization

Journal of Student Research
Pseudomonas fluorescens strain L5.1-96 is exceptional at colonizing wheat roots and resisting desiccation, both characteristics valuable to combatting Take-All disease, a devastating wheat root disease caused by the fungal pathogen Gaeumannomyces graminis var. triciti that drastically decreases wheat crop yield in the state of Washington.
Julia Zhang, Stacy Alvares
openaire   +1 more source

The NAD Kinase Slr0400 Functions as a Growth Repressor in Synechocystis sp. PCC 6803

, 2021
NADP+, the phosphorylated form of nicotinamide adenine dinucleotide (NAD), plays an essential role in many cellular processes. NAD kinase (NADK), which is conserved in all living organisms, catalyzes the phosphorylation of NAD+ to NADP+.
NISHIYAMA, Yoshitaka, SONOIKE, Kintake , SATO, Nozomu, ISHIKAWA, Yuuma, MIYAGI, Atsuko, CASSAN, Cedric, GIBON, Yves, TAKAHASHI, Hiroko, ISHIKAWA, Toshiki, KADEER, Aikeranmu, KAWAI-YAMADA, Maki, YAMAGUCHI, Masatoshi, HIHARA, Yukako, YUASA, Koki, KANEKO, Yasuko   +14 more
core   +1 more source

Enhanced isopropanol–butanol–ethanol mixture production through manipulation of intracellular NAD(P)H level in the recombinant Clostridium acetobutylicum XY16

Biotechnology for Biofuels, 2018
Background The formation of by-products, mainly acetone in acetone–butanol–ethanol (ABE) fermentation, significantly affects the solvent yield and downstream separation process.
Chao Wang, Fengxue Xin, Xiangping Kong, Jie Zhao, Weiliang Dong, Wenming Zhang, Jiangfeng Ma, Hao Wu, Min Jiang   +8 more
doaj   +1 more source

The NADK genes of extant eukaryotes originate from two ancient eukaryotic sister clades of uncertain provenance.

, 2019
Shown is a phylogenetic tree computed by Bayesian inference of NADK genes from the Bacteria (top clades), Eukarya (middle two clades labeled “mito” and cyto”), and the Archaea (bottom gold clade).
Albert Erives (269738), Oliver Vickman (7115075)   +1 more
core   +1 more source

Neoagaro-oligosaccharide delays the postharvest decay of passion fruit and its relationship with the respiratory metabolism [PDF]

Guoshu xuebao
[Objective] The passion (Passiflora caerulea L.) fruit is a typical tropical and subtropical fruit native to Brazil. In China, passion fruit is widely cultivated in Guangxi, Fujian, Hainan, Guangdong and Yunnan Provinces.
LIN Yuzhao, LUO Zhenyu, CHEN Dongxiao, WANG Ying, CHEN Lian, CHEN Hongbin, ZHANG Shen   +6 more
doaj   +1 more source