Results 101 to 110 of about 1,174 (166)

Staphylococcus aureus NAD kinase is required for envelop and antibiotic stress responses

International audienceGlobal burden of infectious diseases and antimicrobial resistance are major public health issues calling for innovative control measures. Bacterial NAD kinase (NADK) is a crucial enzyme for production of NADP(H) and growth.
Mondange, Lou, Pizarro-Cerdá, Javier, Leseigneur, Clarisse, Dussurget, Olivier   +3 more
core   +1 more source

Regulation of NAD kinase in neutrophils

, 2016
NADP+ and NADPH are involved in many biosynthetic pathways and signal transduction mechanisms. NAD kinase (NADK) is the only known enzyme that catalyzes the de novo synthesis of NADP+ from NAD+.
Rabani, Razieh
core  

(−)-Epigallocatechin Gallate is a Noncompetitive Inhibitor of NAD Kinase

Nicotinamide adenine dinucleotide kinase (NADK) controls the intracellular NADPH content and provides reducing power for the synthesis of macromolecules and anti-ROS. Moreover, NADK is considered to be a synthetic lethal gene for KRAS mutations.
Bei Zhang (428038), Mingliang Wang (1666225), Cheng Luo (48047), Wenjia Shi (4726887), Naixia Zhang (474251), Qiqi Wu (4895728), Dean Guo (207402), Qi Li (67548), Tonghai Liu (3447899), Daohai Du (1714372), Bo Han (84102), Jie Zheng (31208), Yiluan Ding (10911999), Hao Zhang (15339)   +13 more
core   +1 more source

DataSheet1.zip

, 2018
NAD(H) and NADP(H) are essential co-enzymes which dominantly control a number of fundamental biological processes by acting as reducing power and maintaining the intracellular redox balance of all life kingdoms.
Abdullah Shalmani (4995410), Wen-Qiang Li (589197), Tian-Tian Ma (566105), Bin-Bin Li (1724083), Xiang Wang (127867), Li Tai (4995407), Kun-Ming Chen (589198), Wen-Ting Liu (350534)   +7 more
core   +1 more source

A Pyroptosis-Related Gene Signature Predicts Prognosis and Tumor Immune Microenvironment in Colorectal Cancer

Technology in Cancer Research & Treatment
Pyroptosis is a programmed cell death, which garners increasing attention by relating to immune and therapy response. However, the role of pyroptosis in colorectal cancer (CRC) remains unclear.
Linjing Li PhD, Yuyi Li MD, Junyi Lin PhD, Wenjing Pang PhD   +3 more
doaj   +1 more source

NAD kinase controls animal NADP biosynthesis and is modulated via evolutionarily divergent calmodulin-dependent mechanisms.

, 2015
Nicotinamide adenine dinucleotide phosphate (NADP) is a critical cofactor during metabolism, calcium signaling, and oxidative defense, yet how animals regulate their NADP pools in vivo and how NADP-synthesizing enzymes are regulated have long remained ...
Love, Nick R, Dölle, Christian, Niere, Marc, Amaya, Enrique; id_orcid, Ziegler, Mathias, Pollak, Nadine, Patel, Sandip, Oliveri, Paola, Chen, Yaoyao   +8 more
core   +1 more source

Unveiling blood pressure‐associated genes in aortic cells through integrative analysis of GWAS and RNA modification‐associated variants

Chronic Diseases and Translational Medicine
Background Genome‐wide association studies (GWAS) have identified more than a thousand loci for blood pressure (BP). Functional genes in these loci are cell‐type specific.
Huan Zhang, Yuxi Chen, Peng Xu, Dan Liu, Naqiong Wu, Laiyuan Wang, Xingbo Mo   +6 more
doaj   +1 more source

Identification and validation of NAD+ metabolism-related biomarkers in patients with diabetic peripheral neuropathy

Frontiers in Endocrinology
BackgroundThe mechanism of Nicotinamide Adenine Dinucleotide (NAD+) metabolism-related genes (NMRGs) in diabetic peripheral neuropathy (DPN) is unclear.
Chenhao Ye, Yuedong Fu, Xijie Zhou, Feiya Zhou, Xuwei Zhu, Yiheng Chen   +5 more
doaj   +1 more source

Data from NUAK1-Mediated Phosphorylation of NADK Mitigates ROS Accumulation to Promote Osimertinib Resistance in Non–Small Cell Lung Carcinoma

<div>Abstract<p>Osimertinib, a third generation epidermal growth factor receptor tyrosine kinase inhibitor, is approved as a first-line therapy in patients with advanced non–small cell lung carcinoma (NSCLC) with EGFR-activating mutations or the T790M resistance mutation.
Yunchong Meng, Yongde Liao, Xiaojun Wang, Peiyuan Mei, Kuo Li, Quanfu Huang, Mingxin Diao, Shihao Wu, Na Wang, Wei Lin   +9 more
openaire   +1 more source

Supplementary Data from NUAK1-Mediated Phosphorylation of NADK Mitigates ROS Accumulation to Promote Osimertinib Resistance in Non–Small Cell Lung Carcinoma

<p>Supplementary information</p>
Yunchong Meng, Yongde Liao, Xiaojun Wang, Peiyuan Mei, Kuo Li, Quanfu Huang, Mingxin Diao, Shihao Wu, Na Wang, Wei Lin   +9 more
openaire   +1 more source