Results 61 to 70 of about 1,174 (166)
Frontiers in Oncology, 2023 BackgroundNicotinamide adenine dinucleotide (NAD+) metabolism is involved in a series of cancer pathogenesis processes, and is considered a promising therapeutic target for cancer treatment.
Cheng Jiang +6 more
doaj +1 more source
Diabetes, Obesity and Metabolism, Volume 27, Issue 12, Page 6894-6904, December 2025.Abstract Aims Type 2 diabetes (T2D) is a highly heterogeneous disease characterised by subtypes with variations in aetiology, disease progression, and risk of complications. However, potential drug targets for these subtypes have not been explored. This study aims to investigate potential drug targets by integrating proteomics.
Jiahe Wei +8 more
wiley +1 more source
浙江大学学报. 农业与生命科学版, 2020 Enzymatic browning is one of the main factors affecting the quality and shelf life of fresh-cut lotus root. The present study aimed to investigate the mechanism of inhibition of elevated carbon dioxide (CO2) on enzymatic browning by applying 20% CO2 to ...
LI Dong +7 more
doaj +1 more source
Exosomes in Metabolic Diseases: From Molecular Mechanisms to Clinical Applications
MedComm – Future Medicine, Volume 4, Issue 3, September 2025.We summarize recent progress in exosome biology and elucidate their roles in interorgan communication networks underlying metabolic pathogenesis. We also comprehensively examine the evolving application of exosomes in metabolic disease management, with a focus on critically evaluating preclinical and clinical advances in exosome‐mediated therapeutic ...
Yanting Wu +3 more
wiley +1 more source
Advanced Science, Volume 12, Issue 19, May 22, 2025.LACK156‐173 is internalized into RA‐FLSs via CAPN2‐mediated endocytosis and inhibits the aggressive phenotype of RA‐FLSs by restoring dysregulated fatty acid synthesis metabolism mediated by overexpressed FASN. The findings suggest that targeting the restoration of fatty acid metabolism could potentially alleviate synovial invasion and joint damage in ...
Jianling Su +17 more
wiley +1 more source
Functions and Regulation of eukaryotic NAD kinase - an essential enzyme for NADP biosynthesis [PDF]
, 2008 NAD and NADP, both major carriers of cellular reducing equivalents, are of vital importance in diverse metabolic and signaling processes. Efficient maintenance and regulation of the reduction-oxidation status is therefore crucial within the cell.
Pollak, Nadine
core +1 more source
The regulation of ferroptosis by MESH1 through the activation of the integrative stress response
Cell Death and Disease, 2021 All organisms exposed to metabolic and environmental stresses have developed various stress adaptive strategies to maintain homeostasis. The main bacterial stress survival mechanism is the stringent response triggered by the accumulation “alarmone” (p ...
Chao-Chieh Lin +6 more
doaj +1 more source
Serum Proteomic and Metabolomic Signatures of High Versus Low Physical Function in Octogenarians
Aging Cell, Volume 24, Issue 5, May 2025.Circulating factors are strongly implicated in modulating biological aging. In this study we show that the serum proteomic and metabolomic profile of high functioning octogenarians suggests lower activation of SASP, preservation of the tryptophan‐kynurenic pathway, higher lipophosphatidyl cholines promoting mitochondrial function, and reduced ...
Ceereena Ubaida‐Mohien +11 more
wiley +1 more source
An ancient duplication of NADK characterizes Nematoda.
, 2019 All nematodes have missing cyto-clade genes, which was lost in connection with a duplication of the ancestral nematode mito-clade gene. Shown is a phylogenetic tree of NADK genes from 11 different nematode genera (highlighted in yellow) that have the ...
Albert Erives (269738) +1 more
core +1 more source
, 2021 Multidrug resistance is a major public health issue, which requires urgent development of new antibiotics and thus identification of original bacterial targets.
Leseigneur, Clarisse
core +1 more source