Results 41 to 50 of about 1,263 (162)

The NAD kinase OsNADK1 affects the intracellular redox balance and enhances the tolerance of rice to drought

BMC Plant Biology, 2020
Background NAD kinases (NADKs) are the only known enzymes that directly phosphorylate NAD(H) to generate NADP(H) in different subcellular compartments. They participate in multiple life activities, such as modulating the NADP/NAD ratio, maintaining the ...
Xiang Wang, Bin-Bin Li, Tian-Tian Ma, Liang-Yu Sun, Li Tai, Chun-Hong Hu, Wen-Ting Liu, Wen-Qiang Li, Kun-Ming Chen   +8 more
doaj   +1 more source

NAD Kinases: Metabolic Targets Controlling Redox Co-enzymes and Reducing Power Partitioning in Plant Stress and Development

Frontiers in Plant Science, 2018
NAD(H) and NADP(H) are essential co-enzymes which dominantly control a number of fundamental biological processes by acting as reducing power and maintaining the intracellular redox balance of all life kingdoms.
Bin-Bin Li, Xiang Wang, Li Tai, Tian-Tian Ma, Abdullah Shalmani, Wen-Ting Liu, Wen-Qiang Li, Kun-Ming Chen   +7 more
doaj   +1 more source

A feedback loop of PPP and PI3K/AKT signal pathway drives regorafenib-resistance in HCC

Cancer & Metabolism, 2023
Background Hepatocellular carcinoma (HCC) is a principal type of liver cancer with high incidence and mortality rates. Regorafenib is a novel oral multikinase inhibitor for second-line therapy for advanced HCC.
Huihua Yang, Dahong Chen, Yafei Wu, Heming Zhou, Wenjing Diao, Gaolin Liu, Qin Li   +6 more
doaj   +1 more source

Enhancing β-Carotene Production in Escherichia coli by Perturbing Central Carbon Metabolism and Improving the NADPH Supply

Frontiers in Bioengineering and Biotechnology, 2020
Beta (β)-carotene (C40H56; a provitamin) is a particularly important carotenoid for human health. Many studies have focused on engineering Escherichia coli as an efficient heterologous producer of β-carotene.
Yuanqing Wu, Yuanqing Wu, Panpan Yan, Panpan Yan, Yang Li, Yang Li, Yang Li, Xuewei Liu, Xuewei Liu, Zhiwen Wang, Zhiwen Wang, Tao Chen, Tao Chen, Xueming Zhao, Xueming Zhao   +14 more
doaj   +1 more source

Rarely, eukaryotic lineages replaced mito NADK genes with horizontal transfer of α-proteobacterial nadK.

, 2019
Choanoflagellates, euglenozoans, and the cnidarian Stylophora pistillata eukaryotic mito-clade NADK genes while also possessing nadk genes apparently acquired from different lineages of α-proteobacteria. These apparent cases of HGT thus appear to be “α2m”
Albert Erives (269738), Oliver Vickman (7115075)   +1 more
core   +1 more source

A combined artificial intelligence–wet lab approach identifies a pivotal role of the NAD+–mitophagy axis on aging and neurodegeneration

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Emerging evidence points to a role of nicotinamide mononucleotide (NAD+) depletion and compromised mitophagy in aging and neurodegenerative diseases. We hypothesize that age‐dependent impairment of the NAD+–mitophagy axis contributes to brain aging and neurodegeneration.
Sofie Lautrup, Shu‐qin Cao, Xi Long, Bonnie Hei Man Liu, Beatriz Escobar‐Doncel, Aristide Ferrante, Johannes Frank, Tomas Schmauck‐Medina, Geoffrey Ho Duen Leung, Kristina Xiao Liang, Ning Lu, Katerina Veverova, Martin Vyhnalek, Frank W. Pun, Alex Zhavoronkov, Evandro Fei Fang   +15 more
wiley   +1 more source

Extramedullary relapse of multiple myeloma defined as the highest risk group based on deregulated gene expression data

Biomedical Papers, 2015
Background: Multiple myeloma (MM) is characterized by malignant proliferation of plasma cells (PC) which accumulate in the bone marrow (BM). The advent of new drugs has changed the course of the disease from incurable to treatable, but most patients ...
Sabina Sevcikova, Helena Paszekova, Lenka Besse, Lenka Sedlarikova, Veronika Kubaczkova, Martina Almasi, Ludek Pour, Roman Hajek   +7 more
doaj   +1 more source

Metabolic Regulation of Macrophages in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Extracellular metabolites drive metabolic rewiring of glucose, lipid, and amino acid pathways in macrophages, steering their polarization toward pro‐ or anti‐inflammatory phenotypes and shaping a wide range of disease processes. Macrophages from different tissues display distinct metabolic signatures, and therapeutic strategies that target these ...
Shan Huang, Yu Zhang, Jiali Min, Jiahui Yang, Yuchen Li, Hao Zhang, Shanshan Liu   +6 more
wiley   +1 more source

MNADK, a novel liver-enriched mitochondrion-localized NAD kinase

Biology Open, 2013
Summary NADP+ and its reducing equivalent NADPH are essential for counteracting oxidative damage. Mitochondria are the major source of oxidative stress, since the majority of superoxide is generated from the mitochondrial respiratory chain. Because NADP+
Ren Zhang
doaj   +1 more source

NAD- and NADPH-Contributing Enzymes as Therapeutic Targets in Cancer: An Overview

Biomolecules, 2020
Actively proliferating cancer cells require sufficient amount of NADH and NADPH for biogenesis and to protect cells from the detrimental effect of reactive oxygen species.
Alvinsyah Adhityo Pramono, Gulam M. Rather, Herry Herman, Keri Lestari, Joseph R. Bertino   +4 more
doaj   +1 more source