Results 41 to 50 of about 1,174 (166)

The NAD kinase OsNADK1 affects the intracellular redox balance and enhances the tolerance of rice to drought

open access: yesBMC Plant Biology, 2020
Background NAD kinases (NADKs) are the only known enzymes that directly phosphorylate NAD(H) to generate NADP(H) in different subcellular compartments. They participate in multiple life activities, such as modulating the NADP/NAD ratio, maintaining the ...
Xiang Wang   +8 more
doaj   +1 more source

Neuronal or Intestinal Knockdown of C. elegans nadk-1 Decreases Oxygen Consumption and Reactive Oxygen Species

open access: yes, 2023
Reactive oxygen species (ROS) such as H2O2 can damage cellular components and are formed as a byproduct of mitochondrial oxidative metabolism. Studies using the nematode C.
Regan, Jake
core   +1 more source

Knockdown of C. elegans NAD Kinases NADK-1 or NADK-2 Induces an Antioxidant Response Without Affecting Lifespan

open access: yes, 2022
Nearly all multicellular organisms show changes in redox balance with aging leading to oxidative damage of macromolecules. This study investigated the role of the [NADP+]/[NADPH] redox couple in aging.
Gong, Henry
core  

Synthesis and structure-activity relationship studies of original cyclic diadenosine derivatives as nanomolar inhibitors of NAD kinase from pathogenic bacteria

open access: yes, 2023
International audienceNicotinamide adenine dinucleotide kinases (NAD kinases) are essential and ubiquitous enzymes involved in the production of NADP(H) which is an essential cofactor in many metabolic pathways.
Mondange, Lou   +9 more
core   +1 more source

Enhancing β-Carotene Production in Escherichia coli by Perturbing Central Carbon Metabolism and Improving the NADPH Supply

open access: yesFrontiers in Bioengineering and Biotechnology, 2020
Beta (β)-carotene (C40H56; a provitamin) is a particularly important carotenoid for human health. Many studies have focused on engineering Escherichia coli as an efficient heterologous producer of β-carotene.
Yuanqing Wu   +14 more
doaj   +1 more source

Rarely, eukaryotic lineages replaced mito NADK genes with horizontal transfer of α-proteobacterial nadK.

open access: yes, 2019
Choanoflagellates, euglenozoans, and the cnidarian Stylophora pistillata eukaryotic mito-clade NADK genes while also possessing nadk genes apparently acquired from different lineages of α-proteobacteria. These apparent cases of HGT thus appear to be “α2m”
Albert Erives (269738)   +1 more
core   +1 more source

Vitamin‐Responsive Disorders: From Molecular Basis to Clinical Presentation and Therapy

open access: yesJournal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT Vitamin‐dependent cofactors are essential for numerous metabolic reactions, and defects affecting their uptake, conversion, utilisation, or regeneration constitute a heterogeneous group of inherited metabolic disorders (IMDs). Although dietary vitamin intake is sufficient to sustain coenzyme synthesis in healthy individuals, it is insufficient
Cécile Acquaviva   +5 more
wiley   +1 more source

Many eukaryotic protists do not possess the mito-clade NADK gene of plants and animals.

open access: yes, 2019
Unlike fungi, amoebozoans, and chlorophytes, all of which have additional NADK cyto-clade genes while missing a mito-clade NADK gene, many eukaryotic protist lineages that are also missing mito-clade NADK genes possess NADK cyto-clade genes that are only
Albert Erives (269738)   +1 more
core   +1 more source

Extramedullary relapse of multiple myeloma defined as the highest risk group based on deregulated gene expression data

open access: yesBiomedical Papers, 2015
Background: Multiple myeloma (MM) is characterized by malignant proliferation of plasma cells (PC) which accumulate in the bone marrow (BM). The advent of new drugs has changed the course of the disease from incurable to treatable, but most patients ...
Sabina Sevcikova   +7 more
doaj   +1 more source

Factors Related to Diabetes Educator Training and Credentialling to Meet the Needs of Rural and Remote Australians

open access: yesAustralian Journal of Rural Health, Volume 34, Issue 2, April 2026.
ABSTRACT Objective With the burden of diabetes rising in Australia, it is important to understand the challenges for rurally based health practitioners to achieve credentialling as a diabetes educator. Setting This is particularly relevant in rural and remote Australia with the shortage of credentialled diabetes educators and the great burden of ...
Arjun Chhabra   +3 more
wiley   +1 more source

Home - About - Disclaimer - Privacy