Results 21 to 30 of about 1,174 (166)

A feedback loop of PPP and PI3K/AKT signal pathway drives regorafenib-resistance in HCC [PDF]

Cancer & Metabolism, 2023
Background Hepatocellular carcinoma (HCC) is a principal type of liver cancer with high incidence and mortality rates. Regorafenib is a novel oral multikinase inhibitor for second-line therapy for advanced HCC.
Huihua Yang, Dahong Chen, Yafei Wu, Heming Zhou, Wenjing Diao, Gaolin Liu, Qin Li   +6 more
doaj   +2 more sources

NMN/NaMN Adenylyltransferase (NMNAT) and NAD Kinase (NADK) Inhibitors: Chemistry and Potential Therapeutic Applications

Current Medicinal Chemistry, 2011
Nicotinamide adenine dinucleotide (NAD(+)) has a crucial role in many cellular processes, both as a coenzyme for redox reactions and as a substrate to donate ADP-ribose units. Thus, enzymes involved in NAD(+) metabolism are attractive targets for drug discovery against a variety of human diseases.
PETRELLI, Riccardo, Felczak K, CAPPELLACCI, Loredana   +2 more
openaire   +4 more sources

Phenylalanine-mediated reprogramming of lipid, pentose phosphate, and energy metabolism delays senescence in Rosa roxburghii fruit [PDF]

Food Chemistry: Molecular Sciences
Although phenylalanine can inhibit fruit senescence, its effects on Rosa roxburghii remain unknown. We hypothesized that it delays senescence by modulating fatty acid metabolism, maintaining energy homeostasis, and supporting pentose phosphate pathways ...
Shuang Liu, Yiwen Zhang, Wei Chang, Yujia Zhou, Xiaochun Ding, Boyu Dong, Xuewu Duan   +6 more
doaj   +2 more sources

The role of respiration metabolism in dicyclohexylcarbodiimide and disodium succinate regulating the pulp breakdown occurrence of fresh longan (Dimocarpus longan Lour.) during storage [PDF]

Food Chemistry: X
Compared to control longan, on day 6, DCC-treated longan presented 18 %, 2 %, 15 %, 34 %, 21 %, 26 % and 10 % higher levels of pulp breakdown index, fruit respiration rate, PGI, SDH, NAD, NADH and QH2, respectively.
Yi Zheng, Yixiong Lin, Hongyi Wen, Yueying Sang, Mengshi Lin, Zhongqi Fan, Hui Wang, Yihui Chen, Yifen Lin, Hetong Lin   +9 more
doaj   +2 more sources

Alpha-ketoglutarate accelerates granulocyte-monocyte progenitor differentiation and atherosclerotic plaque inflammation via oxoglutarate receptor 1 [PDF]

Redox Biology
Accumulating evidence shows that excess cholesterol and glucose uptake stimulates the expansion of hematopoietic stem/progenitor cells and myeloid progenitors, resulting in increased production of inflammatory cells and atherosclerotic progression ...
Jiwei Zhao, Li Su, Wenhao Li, Sin Man Lam, Cen Yan, Taotao Zhou, Yalan Deng, Yuan Dong, Yuan Zhou, Guanghou Shui, Yingmei Feng   +10 more
doaj   +2 more sources

NAD Kinases: Metabolic Targets Controlling Redox Co-enzymes and Reducing Power Partitioning in Plant Stress and Development

Frontiers in Plant Science, 2018
NAD(H) and NADP(H) are essential co-enzymes which dominantly control a number of fundamental biological processes by acting as reducing power and maintaining the intracellular redox balance of all life kingdoms.
Bin-Bin Li, Xiang Wang, Li Tai, Tian-Tian Ma, Abdullah Shalmani, Wen-Ting Liu, Wen-Qiang Li, Kun-Ming Chen   +7 more
doaj   +2 more sources

NMN partially rescues cuproptosis by upregulating sirt2 to increase intracellular NADPH [PDF]

Scientific Reports
Cuproptosis is characterized by lipoylated protein aggregation and loss of iron–sulfur (Fe–S) proteins, which are crucial for a wide range of important cellular functions, including DNA replication and damage repair. Sirt2 and sirt4 are lipoamidases that
Yingying Zhang, Shuting Qiu, Shihan Shao, Yuejia Cao, Yu Hong, Xianrong Xu, Xuexian Fang, Chunhong Di, Jun Yang, Xiaohua Tan   +9 more
doaj   +2 more sources

Construyendo el metabolismo del NAD(P)+ en Plasmodium falciparum: estudio de la NADK y la NMNAT [PDF]

, 2018
La Nicotinamida/Nicotinato monucleótido adenililtransferasa (NMNAT) y la Quinasa del Dinucleótido de adenina y Nicotinamida (NADK) son dos enzimas centrales en el metabolismo del NAD+, la primera de ellas esencial para su síntesis y la segunda para su fosforilación generando NADP+. En el parásito protozoo P.
Guasca Pineda, Laura Katherine
openaire   +2 more sources

6-BA Delays the Senescence of Postharvest Cabbage Leaves by Inhibiting Respiratory Metabolism [PDF]

Foods
6-BA, a small molecule compound of cytokinins, has been proven to delay leaf senescence in different species, including Chinese flowering cabbage; however, its specific mechanism remains relatively unknown. In this study, the application of external 6-BA
Cimei Wang, Yingying Yang, Jieting Yu, Zongli Liu, Wei Wei, Jianye Chen, Jianhua Zhu, Riming Huang   +7 more
doaj   +2 more sources

Synthesis and Enzymatic Evaluation of NAD Mimics as Nicotinamide Adenine Dinucleotide Kinase (NADK) Inhibitors

, 2011
NAD kinase (NADK) is a key enzyme that regulates supply of NADP in the cell. At this time no other pathway of NADP biosynthesis has been found in prokaryotic or eukaryotic cells. Human NAD kinase catalyzes a magnesium- dependent phosphorylation of the 2’-hydroxyl group of the adenosine ribose moiety of NAD using ATP as phosphoryl donor to give NADP ...
CAPPELLACCI, Loredana, PETRELLI, Riccardo, Krzysztof Felczak, VITA, PATRIZIA, TORQUATI, ILARIA, Palmarisa Franchetti, Michele Di Stefano, Giulio Magni, Mario Grifantini, Krzysztof W. Pankiewicz   +9 more
openaire   +2 more sources