Results 31 to 40 of about 1,174 (166)

Downregulation of NAD Kinase Expression in β-Cells Contributes to the Aging-Associated Decline in Glucose-Stimulated Insulin Secretion. [PDF]

Aging Cell
Adequate NADK/NADK2 level is essential to the proper functioning of redox and folate cycles and the purine biosynthesis pathway, and as well as maintenance of GSIS response. During aging, diminished NADK/NADK2 expression alters the metabolic status quo, increasing AICAR production. The latter activates AMPK and suppresses GSIS.
Li GJ, Cheng ML, Lin YT, Ho YH, Lin G, Chiu CY, Ho HY.   +6 more
europepmc   +2 more sources

De Novo Biosynthesis of Antidepressant Psilocybin in Escherichia coli. [PDF]

Microb Biotechnol
Our work achieved de novo synthesis of antidepressant psilocybin in a single engineered Escherichia coli cell. By constructing the P450 PsiH variants with N‐terminal hydrophobic domain modifications, improving the supply of precursor tryptophan and cofactor NADPH, enhancing the electron transfer (ET) pathway and the final methylation step, and ...
Huang Z, Yao Y, Di R, Zhang J, Pan Y, Liu G.   +5 more
europepmc   +2 more sources

Deciphering the functional landscape of phosphosites with deep neural network

Cell Reports, 2023
Summary: Current biochemical approaches have only identified the most well-characterized kinases for a tiny fraction of the phosphoproteome, and the functional assignments of phosphosites are almost negligible. Herein, we analyze the substrate preference
Zhongjie Liang, Tonghai Liu, Qi Li, Guangyu Zhang, Bei Zhang, Xikun Du, Jingqiu Liu, Zhifeng Chen, Hong Ding, Guang Hu, Hao Lin, Fei Zhu, Cheng Luo   +12 more
doaj   +1 more source

The Ca2+-CaM Signaling Pathway Mediates Potassium Uptake by Regulating Reactive Oxygen Species Homeostasis in Tobacco Roots Under Low-K+ Stress

Frontiers in Plant Science, 2021
Potassium (K+) deficiency severely threatens crop growth and productivity. Calcium (Ca2+) signaling and its sensors play a central role in the response to low-K+ stress. Calmodulin (CaM) is an important Ca2+ sensor.
Yingfeng Wang, Xiaoyan Dai, Gaoqiang Xu, Zhuoyi Dai, Peiyu Chen, Tongjin Zhang, Huifen Zhang   +6 more
doaj   +1 more source

Cryo-EM structure and regulation of human NAD kinase. [PDF]

Sci Adv
International audienceReduced nicotinamide adenine dinucleotide phosphate (NADPH) is a crucial reducing cofactor for reductive biosynthesis and protection from oxidative stress.
Praharaj PP, Li Y, Mary C, Soflaee MH, Ryu K, Kim D, Tran DH, Dey T, Tom HJ, Rion H, Gelin M, Lemoff A, Zacharias LG, Patricio JS, Mathews TP, Chen Z, Lionne C, Hoxhaj G, Labesse G.   +18 more
europepmc   +2 more sources

Mitochondrial NAD kinase in health and disease

Redox Biology, 2023
Nicotinamide adenine dinucleotide phosphate (NADP), a co-enzyme and an electron carrier, plays crucial roles in numerous biological functions, including cellular metabolism and antioxidation.
Ren Zhang, Kezhong Zhang
doaj   +1 more source

Multiplex protein profiling of bronchial aspirates reveals disease-, mortality- and respiratory sequelae-associated signatures in critically ill patients with ARDS secondary to SARS-CoV-2 infection

Frontiers in Immunology, 2022
IntroductionBronchial aspirates (BAS) obtained during invasive mechanical ventilation (IMV) constitutes a useful tool for molecular phenotyping and decision making.AimTo identify the proteomic determinants associated with disease pathogenesis, all-cause ...
Marta Molinero, Marta Molinero, Silvia Gómez, Silvia Gómez, Iván D. Benítez, Iván D. Benítez, J. J. Vengoechea, J. J. Vengoechea, Jessica González, Jessica González, Dinora Polanco, Clara Gort-Paniello, Clara Gort-Paniello, Anna Moncusí-Moix, Anna Moncusí-Moix, María C. García-Hidalgo, María C. García-Hidalgo, Manel Perez-Pons, Manel Perez-Pons, Thalía Belmonte, Thalía Belmonte, Gerard Torres, Gerard Torres, Jesús Caballero, Carme Barberà, Jose Ignacio Ayestarán Rota, Lorenzo Socías Crespí, Adrián Ceccato, Laia Fernández-Barat, Laia Fernández-Barat, Ricard Ferrer, Ricard Ferrer, Dario Garcia-Gasulla, Jose Ángel Lorente-Balanza, Jose Ángel Lorente-Balanza, Rosario Menéndez, Rosario Menéndez, Ana Motos, Ana Motos, Oscar Peñuelas, Oscar Peñuelas, Jordi Riera, Jordi Riera, Antoni Torres, Antoni Torres, Ferran Barbé, Ferran Barbé, David de Gonzalo-Calvo, David de Gonzalo-Calvo   +48 more
doaj   +1 more source

Distinct dual roles of p-Tyr42 RhoA GTPase in tau phosphorylation and ATP citrate lyase activation upon different Aβ concentrations

Redox Biology, 2020
Both the accumulation of Amyloid-β (Aβ) in plaques and phosphorylation of Tau protein (p-Tau) in neurofibrillary tangles have been identified as two major symptomatic features of Alzheimer's disease (AD).
Kim Cuong Cap, Yeon-Joo Jung, Bo Young Choi, Seung Jae Hyeon, Jae-Gyu Kim, Jung-Ki Min, Rokibul Islam, Abu Jubayer Hossain, Won-Suk Chung, Sang Won Suh, Hoon Ryu, Jae-Bong Park   +11 more
doaj   +1 more source

One-pot biosynthesis of 7β-hydroxyandrost-4-ene-3,17-dione from phytosterols by cofactor regeneration system in engineered mycolicibacterium neoaurum

Microbial Cell Factories, 2022
Background 7β-hydroxylated steroids (7β-OHSt) possess significant activities in anti-inflammatory and neuroprotection, and some of them have been widely used in clinics.
Yun-Qiu Zhao, Yong-Jun Liu, Wei-Ting Ji, Kun Liu, Bei Gao, Xin-Yi Tao, Ming Zhao, Feng-Qing Wang, Dong-Zhi Wei   +8 more
doaj   +1 more source

Functional identification and subcellular localization of NAD kinase in the protozoan parasite Giardia intestinalis

Revista Colombiana de Química, 2019
Nicotinamide adenine dinucleotide phosphate (NADP) is an essential biomolecule that participates in the redox homeostasis and synthesis of signaling compounds. NAD kinase (NADK) (EC 2.7.1.23/2.7.1.86) is the only enzyme capable of synthesizing NADP. This
Laura Marcela Jutinico Shubach, Luis Ernesto Contreras Rodríguez, Javier Eduardo García Castañeda, María Helena Ramírez Hernández   +3 more
doaj   +1 more source