Results 51 to 60 of about 1,174 (166)

MNADK, a novel liver-enriched mitochondrion-localized NAD kinase

Biology Open, 2013
Summary NADP+ and its reducing equivalent NADPH are essential for counteracting oxidative damage. Mitochondria are the major source of oxidative stress, since the majority of superoxide is generated from the mitochondrial respiratory chain. Because NADP+
Ren Zhang
doaj   +1 more source

NAD- and NADPH-Contributing Enzymes as Therapeutic Targets in Cancer: An Overview

Biomolecules, 2020
Actively proliferating cancer cells require sufficient amount of NADH and NADPH for biogenesis and to protect cells from the detrimental effect of reactive oxygen species.
Alvinsyah Adhityo Pramono, Gulam M. Rather, Herry Herman, Keri Lestari, Joseph R. Bertino   +4 more
doaj   +1 more source

Single‐Cell Hyperthermia: Diamond Quantum Thermometry Reveals Thermal Control of Macrophage Polarization

Advanced Materials, Volume 38, Issue 8, 6 February 2026.
Photothermal nanodiamonds with quantum sensing capabilities generate lysosome‐confined hyperthermia, enabling simultaneous temperature and radical detection via diamond sensing. This localized thermal and oxidative stress drives pro‐inflammatory (M1) macrophage polarization, revealing a new strategy for precision immunomodulation through subcellular ...
Kaiqi Wu, Qi Lu, Yong Ren, Priyadharshini Balasubramanian, Kazem Ebadi Jalal, Hannah Klug, Matthias Klein, Toszka Bohn, Tobias Bopp, Fedor Jelezko, Yingke Wu, Tanja Weil   +11 more
wiley   +1 more source

Hepatocyte‐Derived Extracellular Vesicles Deliver miR‐328‐3p to Trigger PP2A‐B56δ–Mediated p‐NLRP3S295‐Dependent Metaflammation in Macrophages upon Microcystin‐LR Exposure

Advanced Science, Volume 13, Issue 6, 30 January 2026.
Hepatocyte‐derived extracellular vesicles deliver miR‐328‐3p to trigger PP2A‐B56δ–mediated p‐NLRP3S295‐dependent metaflammation in macrophages upon microcystin‐LR exposure. 2‐DG, 2‐deoxy‐D‐glucose. B56δ, protein phosphatase 2A‐B56δ. ER, endoplasmic reticulum. iHD‐EV, inducible hepatocyte‐derived extracellular vesicles. IP3R, inositol 1,4,5‐triphosphate
Jia‐Shen Wu, Xin‐Yu Zhang, Xin‐Yu Ma, Yue‐Yue Wei, Lei‐Lei Wang, Ze‐Bang Du, Xiao‐Gang Xia, Lin Che, Dong‐Bei Guo, Han‐Ying Zheng, You‐Liang Yao, Wen‐Gang Li, Yu‐Chun Lin, Zhong‐Ning Lin   +13 more
wiley   +1 more source

The Nucleotide Kinase Nadk Is Required for ROS Detoxification and Constitutes a Metabolic Vulnerability of NOTCH1-Driven T-ALL

Blood, 2018
Abstract Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer with a cumulative risk of ~1 in 2,000 children by the age of 15 years and an increasing incidence over the last 30 years.Whilst advances in the use of combination chemotherapy have significantly improved outcomes, current treatments remain toxic and can have ...
De Braekeleer, E., Hsu, J., Hervieu, C., Tzelepis, K., Indraccolo, S., Warren, A.J., Jeremias, I., Antoran, D.F., Jones, P.H., Goodell, M.A., Vassiliou, G.S.   +10 more
openaire   +2 more sources

The expansion and evolution of the NADK gene family in plants.

, 2014
(A) Schematic comparison of intron distribution in NADK orthologs of land plants generated with the CIWOG software. Black horizontal lines are aligned sequences; gray horizontal lines are gaps in the alignment; gray vertical bars are conserved common ...
Ri Li (589196), Wen-Qiang Li (589197), Xiang Wang (127867), Wen-Yan Li (589195), Kun-Ming Chen (589198)   +4 more
core   +1 more source

NADPH‐Related Enzymes and Cancer: Facts and Insights Into the Application of Immunohistochemistry

Biochemistry Research International, Volume 2026, Issue 1, 2026.
During tumorigenesis and metastasis, cancer cells initiate antioxidant defense mechanisms to prevent irreversible damage, thereby sustaining tumor growth. The functionality of reactive oxygen species (ROS)–scavenging proteins is dependent on nicotinamide adenine dinucleotide phosphate (NADPH), which is regulated by specific metabolic enzymes, which are
Camila M. Scudeler, Keila Samantha da Silva, Rafaela V. N. Silva, Adilha M. R. Micheletti, Karen B. Ribeiro, Juliana Reis Machado, Régia C. P. Lira, Anup Pathania   +7 more
wiley   +1 more source

S857 THE NUCLEOTIDE KINASE NADK CONSTITUTES A METABOLIC VULNERABILITY OF NOTCH1‐DRIVEN T‐ALL

HemaSphere, 2019
Background:Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer with a cumulative risk of ∼1 in 2,000 children by the age of 15 years and an increasing incidence over the last 30 years.Activating mutations in the NOTCH1gene are found in more than 60% of cases of T‐cell Acute Lymphoblastic leukaemia (T‐ALL) and are being targeted ...
E. De Braekeleer, M. Gu, C. Hervieux, J. Ino Hsu, D. Aspris, E. Abby, V. Baskar, H. Ponstingl, K. Tzelepis, S. Indraccolo, I. Jeremias, D. Fernandez Antoran, M.A. Goodell, P. H Jones, G.S. Vassiliou   +14 more
openaire   +1 more source

Phylogenetic relationships and domain organization of NADK genes in plants.

, 2014
(A) The rooted maximum-likelihood phylogenetic tree of NADK family members was inferred from the amino acid sequence alignment of the NAD_kinase domain. Numbers above the nodes represent bootstrap values from 1000 replications. (B) Domain organization of
Ri Li (589196), Wen-Qiang Li (589197), Xiang Wang (127867), Wen-Yan Li (589195), Kun-Ming Chen (589198)   +4 more
core   +1 more source

From Substrate to Fragments to Inhibitor Active In Vivo against Staphylococcus aureus

, 2020
International audienceAntibiotic resistance is a worldwide threat due to the decreasing supply of new antimicrobials. Novel targets and innovative strategies are urgently needed to generate pathbreaking drug compounds.
Jouvion, Greǵory, Paoletti, Julie, Clément, David, Leseigneur, Clarisse, Huteau, Valeŕie, Assairi, Liliane, Dugué, Laurence, Labesse, Gilles, Gelin, Muriel, Dussurget, Olivier, Pochet, Sylvie, Nahori, Marie-Anne, Pons, Jean-Luc   +12 more
core   +1 more source