Results 71 to 80 of about 1,272 (167)
S857 THE NUCLEOTIDE KINASE NADK CONSTITUTES A METABOLIC VULNERABILITY OF NOTCH1‐DRIVEN T‐ALL
HemaSphere, 2019 Background:Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer with a cumulative risk of ∼1 in 2,000 children by the age of 15 years and an increasing incidence over the last 30 years.Activating mutations in the NOTCH1gene are found in more than 60% of cases of T‐cell Acute Lymphoblastic leukaemia (T‐ALL) and are being targeted ...
E. De Braekeleer +14 more
openaire +1 more source
浙江大学学报. 农业与生命科学版, 2020 Enzymatic browning is one of the main factors affecting the quality and shelf life of fresh-cut lotus root. The present study aimed to investigate the mechanism of inhibition of elevated carbon dioxide (CO2) on enzymatic browning by applying 20% CO2 to ...
LI Dong +7 more
doaj +1 more source
Advanced Science, Volume 13, Issue 6, 30 January 2026.Hepatocyte‐derived extracellular vesicles deliver miR‐328‐3p to trigger PP2A‐B56δ–mediated p‐NLRP3S295‐dependent metaflammation in macrophages upon microcystin‐LR exposure. 2‐DG, 2‐deoxy‐D‐glucose. B56δ, protein phosphatase 2A‐B56δ. ER, endoplasmic reticulum. iHD‐EV, inducible hepatocyte‐derived extracellular vesicles. IP3R, inositol 1,4,5‐triphosphate
Jia‐Shen Wu +13 more
wiley +1 more source
Blood, 2018 Abstract Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer with a cumulative risk of ~1 in 2,000 children by the age of 15 years and an increasing incidence over the last 30 years.Whilst advances in the use of combination chemotherapy have significantly improved outcomes, current treatments remain toxic and can have ...
De Braekeleer, E. +10 more
openaire +2 more sources
From Substrate to Fragments to Inhibitor Active In Vivo against Staphylococcus aureus
, 2020 International audienceAntibiotic resistance is a worldwide threat due to the decreasing supply of new antimicrobials. Novel targets and innovative strategies are urgently needed to generate pathbreaking drug compounds.
Jouvion, Greǵory +12 more
core +1 more source
A bacterial duplication of nadK in the Firmicutes class of Bacilli.
, 2019 Identification of a duplication of nadK into ppnKA and ppnKB in the occurred after the Bacilli class split with its sister class of Clostridia.
Albert Erives (269738) +1 more
core +1 more source
Functions and Regulation of eukaryotic NAD kinase - an essential enzyme for NADP biosynthesis [PDF]
, 2008 NAD and NADP, both major carriers of cellular reducing equivalents, are of vital importance in diverse metabolic and signaling processes. Efficient maintenance and regulation of the reduction-oxidation status is therefore crucial within the cell.
Pollak, Nadine
core +1 more source
An ancient duplication of NADK characterizes Nematoda.
, 2019 All nematodes have missing cyto-clade genes, which was lost in connection with a duplication of the ancestral nematode mito-clade gene. Shown is a phylogenetic tree of NADK genes from 11 different nematode genera (highlighted in yellow) that have the ...
Albert Erives (269738) +1 more
core +1 more source
Function of Pseudomonas fluorescens L5.1-96 proteins MPPE and NADK in wheat root colonization
Journal of Student ResearchPseudomonas fluorescens strain L5.1-96 is exceptional at colonizing wheat roots and resisting desiccation, both characteristics valuable to combatting Take-All disease, a devastating wheat root disease caused by the fungal pathogen Gaeumannomyces graminis var. triciti that drastically decreases wheat crop yield in the state of Washington.
Julia Zhang, Stacy Alvares
openaire +1 more source
, 2021 Multidrug resistance is a major public health issue, which requires urgent development of new antibiotics and thus identification of original bacterial targets.
Leseigneur, Clarisse
core +1 more source