Results 71 to 80 of about 1,174 (166)

MMFuncPhos: A Multi‐Modal Learning Framework for Identifying Functional Phosphorylation Sites and Their Regulatory Types

Advanced Science, Volume 12, Issue 9, March 6, 2025.
The functions of most phosphorylation sites remain unknown, which is the “bottleneck” of phosphorylation modification studies. Here, a state‐of‐the‐art method, MMFuncPhos, is developed to predict functional phosphorylation sites based on a multi‐modal deep learning framework.
Juan Xie, Ruihan Dong, Jintao Zhu, Haoyu Lin, Shiwei Wang, Luhua Lai   +5 more
wiley   +1 more source

A bacterial duplication of nadK in the Firmicutes class of Bacilli.

, 2019
Identification of a duplication of nadK into ppnKA and ppnKB in the occurred after the Bacilli class split with its sister class of Clostridia.
Albert Erives (269738), Oliver Vickman (7115075)   +1 more
core   +1 more source

Association Analysis of the Circulating Proteome With Sarcopenia‐Related Traits Reveals Potential Drug Targets for Sarcopenia

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 1, February 2025.
ABSTRACT Background Sarcopenia severely affects the physical health of the elderly. Currently, there is no specific drug available for sarcopenia. This study aims to identify pathogenic proteins and druggable targets for sarcopenia through Mendelian randomization (MR)–based analytical framework.
Simin Wen, Siqi Xu, Xizeng Zong, Shifeng Wen, Wende Xiao, Weipeng Zheng, Han Cen, Zhaohua Zhu, Jingyu Xie, Yan Zhang, Changhai Ding, Guangfeng Ruan   +11 more
wiley   +1 more source

Impact of Ultraviolet‐C Light on Softening and Senescence During Storage of Peach Fruit

Journal of Food Biochemistry, Volume 2025, Issue 1, 2025.
Ultraviolet‐C (UV‐C), as a physical preservation technology, has the advantages of energy saving, safety, and sanitation and has broad application prospects in fruit storage. In this study, peach cultivated “Xiahui 5” was used as material to investigate the impact of UV‐C on the softening, senescence, and postharvest quality of peaches.
Juan Kan, Min Gao, Weixiao Dong, Chao Tang, Chunlu Qian, Jun Liu, Rui M. S. Cruz   +6 more
wiley   +1 more source

External Sucrose Delays Pakchoi Senescence Through Regulating Energy Metabolism

Journal of Food Processing and Preservation, Volume 2025, Issue 1, 2025.
As a typical green leafy vegetable, pakchoi suffers greatly from postharvest loss. This study investigated the impact of sucrose on quality and energy metabolism of postharvest pakchoi. Sucrose could delay leaf yellowing and preserve higher chlorophyll and decrease weight loss rate and respiration rate during pakchoi storage. Compared with control, the
Siyi Wang, Yanchao Han, Guangzhen Yang, Yongqiang Ma, Jiatao Wang, Chao Han, Zuolong Yu, Changchun Fu, Essam Hebishy   +8 more
wiley   +1 more source

NADPH regulates human NAD kinase, a NADP⁺-biosynthetic enzyme. [PDF]

, 2011
NAD kinase (NADK, EC 2.7.1.23) is the sole NADP(+)-biosynthetic enzyme that catalyzes phosphorylation of NAD(+) to yield NADP(+) using ATP as a phosphoryl donor, and thus, plays a vital role in the cell and represents a potentially powerful antimicrobial
Kazuto Ohashi, Mari Koshimizu, Koshimizu, Mari, Murata, Kousaku, Kawai, Shigeyuki, Shigeyuki Kawai, Ohashi, Kazuto, Kousaku Murata   +7 more
core   +1 more source

A single‐cell transcriptomic atlas of severe intrauterine adhesion

MedComm – Future Medicine, Volume 3, Issue 4, December 2024.
Analyzing transcriptomes from over 72,000 cells in Intrauterine adhesion (IUA) and normal endometrial tissues revealed cellular and molecular changes associated with IUA. Activated TREM2+ macrophages and vulnerable Annexin A1+ NK cell subtypes were identified.
Siyu Xia, Wenting Ye, Jiajun Zeng, Ge Song, Yan Sun, Yongmei Zhang, Xiaoqing Luo, Jing Cai, Hongjin Yu, Wenwei Pan, Jiayun Chen, Chuanbin Yang, Qingming Luo, Jigang Wang, Yali Song   +14 more
wiley   +1 more source

Redox Profiling of NAD Kinase in Acute Kidney Injury

, 2023
Title: Redox Profiling of NAD Kinase in Acute Kidney Injury Authors: Emily Q. Quach Pharm.D. Candidate 2023, Liang-Jun Yan PhD. Abstract Background: Acute kidney injury (AKI) is a common clinical disorder in hospitalized patients and is characterized ...
Quach, Emily, Yan, Liang-Jun
core  

Structure‐based design, synthesis and biological evaluation of a NAD+ analogue targeting Pseudomonas aeruginosa NAD kinase

, 2022
International audienceMulti-drug resistance is a major public health problem that requires the urgent development of new antibiotics and therefore the identification of novel bacterial targets.
Gilles Labesse, Sylvie Pochet, Huteau, Valérie, Nogaret, Pauline, Pauline Nogaret, Clément, David,, Valérie Huteau, Rahila Rahimova, Anne‐Béatrice Blanc‐Potard, Rahimova, Rahila, Blanc-Potard, Anne‐béatrice, Lionne, Corinne, Labesse, Gilles, Clément, David, A., Corinne Lionne, David A. Clément, Gelin, Muriel, Pochet, Sylvie, Muriel Gelin   +18 more
core   +1 more source

Inducing disulfidptosis in tumors:potential pathways and significance

MedComm, Volume 5, Issue 11, November 2024.
Exploring the mechanisms of disulfidptosis reveals potential pathways to induce tumor cell death. Tumor cells with high SLC7A11 expression uptake a large amount of cystine to meet their metabolic needs. The reduction of cystine requires the involvement of the Trx system and NADPH.
Tao Mi, Xiangpan Kong, Meiling Chen, Peng Guo, Dawei He   +4 more
wiley   +1 more source