Serum proteome profiling of plateau acclimatization in men using Olink proteomics approach [PDF]
Physiological ReportsPlateau acclimatization involves adaptive changes in the body's neurohumoral regulation and metabolic processes due to hypoxic conditions at high altitudes.
Jingyu Pan +7 more
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Transcriptional Isoforms of NAD+ kinase regulate oxidative stress resistance and melanoma metastasis [PDF]
Redox BiologyMetastasizing cancer cells encounter a multitude of stresses throughout the metastatic cascade. Oxidative stress is known to be a major barrier for metastatic colonization, such that metastasizing cancer cells must rewire their metabolic pathways to ...
Graciela Cascio +7 more
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eLife, 2022 Nicotinamide adenine dinucleotide phosphate (NADPH) is the primary electron donor for reductive reactions that are essential for the biosynthesis of major cell components in all organisms.
Clarisse Leseigneur +6 more
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Knockdown of NADK promotes LUAD ferroptosis via NADPH/FSP1 axis [PDF]
Journal of Cancer Research and Clinical OncologyAbstract Background Lung cancer is a serious threat to human health and is the first leading cause of cancer death. Ferroptosis, a newly discovered form of programmed cell death associated with redox homeostasis, is of particular interest in the lung cancer, given the high oxygen environment of lung cancer.
Shujuan Shao +2 more
exaly +4 more sources
Mitochondrial NADK, a Novel Functional Mediator of Tau Toxicity in Alzheimer's Disease [PDF]
Alzheimers DementAbstract Tau was first described in a 1975 PNAS paper from Marc Kirschner's lab as a brain protein that stimulates the polymerization of tubulin into microtubules (https://doi.org/10.1073/pnas.72.5.1858). Unbeknown at that time was the fact that tau is the building block of neurofibrillary tangles, and a central player in the pathogenesis of Alzheimer ...
Norambuena A.
europepmc +3 more sources
Differential expression of NADK in cancer of the skin: malignant melanoma.
, 2023 Skin cancer is diagnosed in nearly 1.5 million patients each year (1). While patients with basal and squamous cell carcinomas are provided with 5-year survival rates at nearly 100% and 90%, respectively, patients diagnosed with cutaneous melanoma (metastatic melanoma) are provided 5-year survival rates at 91.4% at stage I and 24.6% at stage IV (2-5 ...
Shahan Mamoor
openaire +2 more sources
NFATc1-mediated activation of the pentose phosphate pathway and cell cycle dysregulation collectively drive tumor progression [PDF]
OncogenesisThe pentose phosphate pathway (PPP) supplies abundant reducing equivalents and biosynthetic precursors to support the rapid proliferation of tumor cells. An increased PPP flux is a hallmark of metabolic reprogramming in tumors. Although nuclear factor of
Suyang Zhang +8 more
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Adipose tissue macrophage-derived miR-690 modulates adipocyte precursor cell maintenance and adipogenesis [PDF]
Molecular MetabolismObesity is intricately linked to various metabolic diseases; however, some individuals maintain metabolic health despite being classified as obese. A critical factor underlying this paradox is the expansion of white adipose tissue (WAT), which can occur ...
Karina Cunha e Rocha +11 more
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Niacin Alleviates Browning in Fresh-Cut Potatoes: Regulation of NADPH/NADH Levels Mediates ROS-Redox Homeostasis and the Ascorbate–Glutathione Cycle [PDF]
FoodsNiacin contents vary significantly among fresh-cut potato cultivars with different browning sensitivities, whereas its role as a browning inhibitor for fresh-cut produce has not been previously reported.
Jiaxuan Zheng +7 more
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Advanced Biomedical Research, 2017 Background:Staphylococcus aureus has the ability to form biofilms on any niches, a key pathogenic factor of this organism and this phenomenon is directly related to the concentration of NADPH.
U Venkateswara Prasad +7 more
doaj +2 more sources