Results 11 to 20 of about 1,263 (162)
Calmodulin Is the Fundamental Regulator of NADK-Mediated NAD Signaling in Plants [PDF]
Frontiers in Plant Science, 2019 Calcium (Ca2+) signaling and nicotinamide adenine dinucleotide (NAD) signaling are two basic signal regulation pathways in organisms, playing crucial roles in signal transduction, energy metabolism, stress tolerance, and various developmental processes ...
Kun-Ming Chen +2 more
exaly +5 more sources
eLife, 2022 Nicotinamide adenine dinucleotide phosphate (NADPH) is the primary electron donor for reductive reactions that are essential for the biosynthesis of major cell components in all organisms.
Clarisse Leseigneur +6 more
doaj +2 more sources
Mitochondrial NADK, a Novel Functional Mediator of Tau Toxicity in Alzheimer's Disease [PDF]
Alzheimers DementAbstract Tau was first described in a 1975 PNAS paper from Marc Kirschner's lab as a brain protein that stimulates the polymerization of tubulin into microtubules (https://doi.org/10.1073/pnas.72.5.1858). Unbeknown at that time was the fact that tau is the building block of neurofibrillary tangles, and a central player in the pathogenesis of Alzheimer ...
Norambuena A.
europepmc +3 more sources
Knockdown of NADK promotes LUAD ferroptosis via NADPH/FSP1 axis [PDF]
Journal of Cancer Research and Clinical OncologyAbstract Background Lung cancer is a serious threat to human health and is the first leading cause of cancer death. Ferroptosis, a newly discovered form of programmed cell death associated with redox homeostasis, is of particular interest in the lung cancer, given the high oxygen environment of lung cancer.
Shujuan Shao, Xinming Chi
exaly +4 more sources
Differential expression of NADK in cancer of the skin: malignant melanoma.
, 2023 Skin cancer is diagnosed in nearly 1.5 million patients each year (1). While patients with basal and squamous cell carcinomas are provided with 5-year survival rates at nearly 100% and 90%, respectively, patients diagnosed with cutaneous melanoma (metastatic melanoma) are provided 5-year survival rates at 91.4% at stage I and 24.6% at stage IV (2-5 ...
Shahan Mamoor
openaire +2 more sources
Adipose tissue macrophage-derived miR-690 modulates adipocyte precursor cell maintenance and adipogenesis [PDF]
Molecular MetabolismObesity is intricately linked to various metabolic diseases; however, some individuals maintain metabolic health despite being classified as obese. A critical factor underlying this paradox is the expansion of white adipose tissue (WAT), which can occur ...
Karina Cunha e Rocha +11 more
doaj +2 more sources
Niacin Alleviates Browning in Fresh-Cut Potatoes: Regulation of NADPH/NADH Levels Mediates ROS-Redox Homeostasis and the Ascorbate–Glutathione Cycle [PDF]
FoodsNiacin contents vary significantly among fresh-cut potato cultivars with different browning sensitivities, whereas its role as a browning inhibitor for fresh-cut produce has not been previously reported.
Jiaxuan Zheng +7 more
doaj +2 more sources
Current Medicinal Chemistry, 2011 Nicotinamide adenine dinucleotide (NAD(+)) has a crucial role in many cellular processes, both as a coenzyme for redox reactions and as a substrate to donate ADP-ribose units. Thus, enzymes involved in NAD(+) metabolism are attractive targets for drug discovery against a variety of human diseases.
PETRELLI, Riccardo +2 more
core +5 more sources
Transcriptional Isoforms of NAD+ kinase regulate oxidative stress resistance and melanoma metastasis [PDF]
Redox BiologyMetastasizing cancer cells encounter a multitude of stresses throughout the metastatic cascade. Oxidative stress is known to be a major barrier for metastatic colonization, such that metastasizing cancer cells must rewire their metabolic pathways to ...
Graciela Cascio +7 more
doaj +2 more sources
Phenylalanine-mediated reprogramming of lipid, pentose phosphate, and energy metabolism delays senescence in Rosa roxburghii fruit [PDF]
Food Chemistry: Molecular SciencesAlthough phenylalanine can inhibit fruit senescence, its effects on Rosa roxburghii remain unknown. We hypothesized that it delays senescence by modulating fatty acid metabolism, maintaining energy homeostasis, and supporting pentose phosphate pathways ...
Shuang Liu +6 more
doaj +2 more sources