Results 141 to 150 of about 2,008 (163)

Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization. [PDF]

Nat Metab
Rohm TV, Castellani Gomes Dos Reis F, Isaac R, Murphy C, Cunha E Rocha K, Bandyopadhyay G, Gao H, Libster AM, Zapata RC, Lee YS, Ying W, Miciano C, Wang A, Olefsky JM.   +13 more
europepmc   +1 more source

Unraveling the nexus: Genomic instability and metabolism in cancer. [PDF]

Cell Rep
Gujar V, Li H, Paull TT, Neumann CA, Weyemi U.   +4 more
europepmc   +1 more source

Comparative Assessment of Acute Pulmonary Effects Induced by Heat-Not-Burn Tobacco Aerosol Inhalation in a Murine Model. [PDF]

Int J Mol Sci
Kim BK, Yang WJ, Seong YS, Choi YJ, Park HJ, Byun MK, Chang YS, Cho JH, Kim CY.   +8 more
europepmc   +1 more source

Emergence of NDM-type metallo-β-lactamase and ArmA 16S rRNA methylase co-producing Morganella morganii in Myanmar. [PDF]

BMC Infect Dis
Kirikae M, Takei S, Uehara Y, Oshiro S, Hom NS, Hosoya S, Soe PE, Htoon TT, Setk S, Tin HH, Kirikae T, Tada T.   +11 more
europepmc   +1 more source

Elevating cytosolic NADPH metabolism in endothelial cells ameliorates vascular aging. [PDF]

Nat Commun
Wu D, Tan B, Cheng Z, Li H, Li H, Yin Y, Ma F, Chen T, Dong X, Wang W, Hu Q.   +10 more
europepmc   +1 more source

DNA Methylation Patterns Associated with Tinnitus in Young Adults-A Pilot Study. [PDF]

J Assoc Res Otolaryngol
Bhatt IS, Garay JAR, Torkamani A, Dias R.   +3 more
europepmc   +1 more source

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NMN/NaMN Adenylyltransferase (NMNAT) and NAD Kinase (NADK) Inhibitors: Chemistry and Potential Therapeutic Applications

Current Medicinal Chemistry, 2011
Nicotinamide adenine dinucleotide (NAD(+)) has a crucial role in many cellular processes, both as a coenzyme for redox reactions and as a substrate to donate ADP-ribose units. Thus, enzymes involved in NAD(+) metabolism are attractive targets for drug discovery against a variety of human diseases.
PETRELLI, Riccardo, Felczak K, CAPPELLACCI, Loredana   +2 more
openaire   +3 more sources

NADK upregulation is an essential metabolic adaptation that enables breast cancer metastatic colonization

2022
AbstractMetabolic reprogramming and metabolic plasticity allow cancer cells to fine-tune their metabolism to adapt to the ever-changing environments of the metastatic cascade, for which lipid metabolism and oxidative stress are of particular importance.
Didem Ilter, Tanya Schild, Nathan P. Ward, Stanislav Drapela, Emma Adhikari, Vivien Low, Eric Le-Lau, Gina M. DeNicola, Melanie R. McReynolds, Ana P. Gomes   +9 more
openaire   +1 more source

NADK is Activated by Oncogenic KRAS Signaling to Sustain Pancreatic Ductal Adenocarcinoma

SSRN Electronic Journal, 2020
Metabolic adaptations and the signaling events that control them have been implicated in the adaptation of pancreatic ductal adenocarcinoma (PDAC) to survive stresses associated with nutrient and oxygen deprivation at the tumor site. Recently, rewiring of NADPH production has been shown to play a key role in this process.
Tanya Schild, Melanie McReynolds, Christie Shea, Vivien Low, John Asara, Noah Dephoure, Joshua D. Rabinowitz, Ana P. Gomes, John Blenis   +8 more
openaire   +1 more source