Results 151 to 160 of about 1,272 (167)

Palmitoylation-dependent activation of NADK promotes NADP ⁺ synthesis and tumorigenesis

Abstract NAD kinase (NADK) is the sole cytosolic enzyme that catalyzes the synthesis of nicotinamide adenine dinucleotide phosphate (NADP + ) from NAD + .
Luojun Chen, Wanjun Zhang, Yue Zhu, Xiaoke Xing, Yi Yao, Huadong Pei, Yali Chen, Weijie Qin, Pingfeng Zhang   +8 more
openaire   +1 more source

Abstract 1800: Cytosolic NADK is conditionally essential for folate-dependent nucleotide synthesis in human cells

Cancer Research
Abstract The genes that are required for the growth of mammalian cells can depend on an interplay of cell-intrinsic factors and environmental context. However, there is often little investigation into how nutrient availability impacts gene essentiality. Moreover, efforts such as DepMap have catalogued genes that contribute to cancer cell
Kyle M. Flickinger, Kimberly S. Huggler, Jason R. Cantor   +2 more
openaire   +1 more source

Schisandra total lignans ameliorate neuronal ferroptosis in 3xTg-AD mice via regulating NADK/NADPH/GSH pathway

Phytomedicine
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with limited treatments. Schisandra total lignans (STL), the primary active component of Schisandra chinensis, shows potential in alleviating AD-related symptoms, though the mechanisms remain unclear.Considering the promoting effect of neuronal ferroptosis on AD and the ...
Yuying Wu, Mengying Wei, Mengyao Wang, Minsong Guo, Hengyuan Yu, Yong Chen, Tengfei Xu, Yuan Zhou   +7 more
openaire   +2 more sources

Abstract 7244: AMPK interacts with PRC1.1 complex on chromatin to regulate NADK expression in response to metabolic stress in acute lymphoblastic leukemia

Cancer Research
Abstract Acute lymphoblastic leukemia (ALL) remains a leading cause of pediatric cancer-related mortality. ALL cells are particularly vulnerable to metabolic stress following activation of AMP-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis.
Anna Shvab, Guy J. Leclerc, Julio C. Barredo   +2 more
openaire   +1 more source

Selective inhibition of nicotinamide adenine kinases (NADKs) by compact NAD mimics

2009
We have examined sequence diversity of 147 co-crystal structures of proteins utilizing NAD as a cofactor or as a substrate. Most of these proteins bind NAD in an extended conformations. However, there are clear exceptions to this general trend. Several bacterial reductases bind NAD in an extremely folded conformations.
PETRELLI, Riccardo, Felczak K, Chen L, VITA, PATRIZIA, CAPPELLACCI, Loredana, FRANCHETTI, Palmarisa, GRIFANTINI, Mario, Di Stefano M, Magni G, Pankiewicz K.   +9 more
openaire   +1 more source

Chloroplast NADK is necessary for regulation of carbon and nitrate metabolism

Plant and Cell Physiology Supplement, 2007
Takahashi, Hideyuki, Hashida, Sin-nosuke, Tanaka, Ayumi, Sonoike, Kintake, Kawai, Maki, Uchimiya, Hirofumi   +5 more
openaire   +1 more source

Loss of peroxisomal NAD kinase 3 (NADK3) affects photorespiration metabolism in Arabidopsis

Journal of Plant Physiology, 2023
Maki Kawai-Yamada, Masaru Kono, Kentaro Takahara   +2 more
exaly  

NADK-mediated NADP(H) synthesis is a metabolic adaptation essential for breast cancer metastasis

Redox Biology, 2023
exaly  

NAD kinase sustains lipogenesis and mitochondrial metabolismthrough fatty acid synthesis

Cell Reports, 2021
Long Ding, Xun Huang, Yingchun Wang
exaly  

NADK3, a novel cytoplasmic source of NADPH, is required under conditions of oxidative stress and modulates abscisic acid responses in Arabidopsis

Plant Journal, 2006
Shuhua Yang, Xue-Chen Wang
exaly