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NADK-mediated proline synthesis enhances high-salinity tolerance in the razor clam
Comparative Biochemistry and Physiology Part A, Molecular & Integrative PhysiologyEuryhaline organisms can accumulate organic osmolytes to maintain osmotic balance between their internal and external environments. Proline is a pivotal organic small molecule and plays an important role in osmoregulation that enables marine shellfish to tolerate high-salinity conditions. During high-salinity challenge, NAD kinase (NADK) is involved in
Liang Jia, Donghong Niu
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2022
Abstract Metabolic reprogramming and metabolic plasticity allow cancer cells to fine-tune their metabolism to adapt to the ever-changing environments of the metastatic cascade, for which lipid metabolism and oxidative stress are of particular importance.
Didem Ilter +9 more
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Abstract Metabolic reprogramming and metabolic plasticity allow cancer cells to fine-tune their metabolism to adapt to the ever-changing environments of the metastatic cascade, for which lipid metabolism and oxidative stress are of particular importance.
Didem Ilter +9 more
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NADK is Activated by Oncogenic KRAS Signaling to Sustain Pancreatic Ductal Adenocarcinoma
SSRN Electronic Journal, 2020Metabolic adaptations and the signaling events that control them have been implicated in the adaptation of pancreatic ductal adenocarcinoma (PDAC) to survive stresses associated with nutrient and oxygen deprivation at the tumor site. Recently, rewiring of NADPH production has been shown to play a key role in this process.
Tanya Schild +8 more
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Phytomedicine
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with limited treatments. Schisandra total lignans (STL), the primary active component of Schisandra chinensis, shows potential in alleviating AD-related symptoms, though the mechanisms remain unclear.Considering the promoting effect of neuronal ferroptosis on AD and the ...
Mengyao Wang, Tengfei Xu, Yong Chen
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Alzheimer's disease (AD) is a progressive neurodegenerative disorder with limited treatments. Schisandra total lignans (STL), the primary active component of Schisandra chinensis, shows potential in alleviating AD-related symptoms, though the mechanisms remain unclear.Considering the promoting effect of neuronal ferroptosis on AD and the ...
Mengyao Wang, Tengfei Xu, Yong Chen
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Theoretical and Natural Science
Lung cancer remains the leading cause of cancer-related deaths, and ferroptosis has emerged as a potential therapeutic target due to its role in tumor suppression. RSL3, a GPX4 inhibitor, and NADK knockdown both promote ferroptosis, but their relationship in lung cancer treatment remains unexplored.
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Lung cancer remains the leading cause of cancer-related deaths, and ferroptosis has emerged as a potential therapeutic target due to its role in tumor suppression. RSL3, a GPX4 inhibitor, and NADK knockdown both promote ferroptosis, but their relationship in lung cancer treatment remains unexplored.
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Cancer Research
Abstract Osimertinib, a third generation epidermal growth factor receptor tyrosine kinase inhibitor, is approved as a first-line therapy in patients with advanced non–small cell lung carcinoma (NSCLC) with EGFR-activating mutations or the T790M resistance mutation.
Wei Lin, Na Wang, Shihao Wu
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Abstract Osimertinib, a third generation epidermal growth factor receptor tyrosine kinase inhibitor, is approved as a first-line therapy in patients with advanced non–small cell lung carcinoma (NSCLC) with EGFR-activating mutations or the T790M resistance mutation.
Wei Lin, Na Wang, Shihao Wu
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Cancer Research
Abstract The genes that are required for the growth of mammalian cells can depend on an interplay of cell-intrinsic factors and environmental context. However, there is often little investigation into how nutrient availability impacts gene essentiality. Moreover, efforts such as DepMap have catalogued genes that contribute to cancer cell
Kyle M. Flickinger +2 more
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Abstract The genes that are required for the growth of mammalian cells can depend on an interplay of cell-intrinsic factors and environmental context. However, there is often little investigation into how nutrient availability impacts gene essentiality. Moreover, efforts such as DepMap have catalogued genes that contribute to cancer cell
Kyle M. Flickinger +2 more
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Palmitoylation-dependent activation of NADK promotes NADP + synthesis and tumorigenesis
Abstract NAD kinase (NADK) is the sole cytosolic enzyme that catalyzes the synthesis of nicotinamide adenine dinucleotide phosphate (NADP + ) from NAD + .Luojun Chen +8 more
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Cancer Research
Abstract Acute lymphoblastic leukemia (ALL) remains a leading cause of pediatric cancer-related mortality. ALL cells are particularly vulnerable to metabolic stress following activation of AMP-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis.
Anna Shvab +2 more
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Abstract Acute lymphoblastic leukemia (ALL) remains a leading cause of pediatric cancer-related mortality. ALL cells are particularly vulnerable to metabolic stress following activation of AMP-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis.
Anna Shvab +2 more
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Selective inhibition of nicotinamide adenine kinases (NADKs) by compact NAD mimics
2009We have examined sequence diversity of 147 co-crystal structures of proteins utilizing NAD as a cofactor or as a substrate. Most of these proteins bind NAD in an extended conformations. However, there are clear exceptions to this general trend. Several bacterial reductases bind NAD in an extremely folded conformations.
PETRELLI, Riccardo +9 more
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