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Exploratory Study of Virulence Factors and Protein-Protein Interaction Networks in Major Oral Pathogens. [PDF]
Contemp Clin DentMurmu M, Singh R, Barage S, Kumar AWS.
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The Warburg Effect Suppresses Ferroptosis Through Activation of NADPH Sensing
Halsey C +18 more
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Identification and Functional Analysis of the NADK Gene Family in Wheat
Plant Molecular Biology Reporter, 2015NAD(H) kinase (NADK) is a key enzyme for maintaining the cellular NAD(H)/NADP(H) balance and for NADP(H)-based metabolic pathways. We identified four NADK homologs, NADK1–4, from three major cereal crops, wheat, rice and maize, based on their phylogenetic relationships and gene structures.
Kun-Ming Chen, Izhar Muhammad
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Cytosolic NADK is conditionally essential for folate-dependent nucleotide synthesis
Nature MetabolismNicotinamide adenine dinucleotide kinase (NADK) catalyses the phosphorylation of NAD+ to produce NAD phosphate, the oxidized form of NADPH, a cofactor that serves a critical role in driving reductive metabolism. Cancer cells co-express two distinct NAD kinases that differ by localization (NADK, cytosol; NADK2, mitochondria).
Jason Cantor +2 more
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NADK is Activated by Oncogenic KRAS Signaling to Sustain Pancreatic Ductal Adenocarcinoma
SSRN Electronic Journal, 2020Metabolic adaptations and the signaling events that control them have been implicated in the adaptation of pancreatic ductal adenocarcinoma (PDAC) to survive stresses associated with nutrient and oxygen deprivation at the tumor site. Recently, rewiring of NADPH production has been shown to play a key role in this process.
Tanya Schild +8 more
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NADK-mediated proline synthesis enhances high-salinity tolerance in the razor clam
Comparative Biochemistry and Physiology Part A, Molecular & Integrative PhysiologyEuryhaline organisms can accumulate organic osmolytes to maintain osmotic balance between their internal and external environments. Proline is a pivotal organic small molecule and plays an important role in osmoregulation that enables marine shellfish to tolerate high-salinity conditions. During high-salinity challenge, NAD kinase (NADK) is involved in
Donghong Niu
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2022
Abstract Metabolic reprogramming and metabolic plasticity allow cancer cells to fine-tune their metabolism to adapt to the ever-changing environments of the metastatic cascade, for which lipid metabolism and oxidative stress are of particular importance.
Didem Ilter +9 more
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Abstract Metabolic reprogramming and metabolic plasticity allow cancer cells to fine-tune their metabolism to adapt to the ever-changing environments of the metastatic cascade, for which lipid metabolism and oxidative stress are of particular importance.
Didem Ilter +9 more
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Cancer Research
Abstract Osimertinib, a third generation epidermal growth factor receptor tyrosine kinase inhibitor, is approved as a first-line therapy in patients with advanced non–small cell lung carcinoma (NSCLC) with EGFR-activating mutations or the T790M resistance mutation.
Yongde Liao, Mei Peiyuan, Na Wang
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Abstract Osimertinib, a third generation epidermal growth factor receptor tyrosine kinase inhibitor, is approved as a first-line therapy in patients with advanced non–small cell lung carcinoma (NSCLC) with EGFR-activating mutations or the T790M resistance mutation.
Yongde Liao, Mei Peiyuan, Na Wang
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Theoretical and Natural Science
Lung cancer remains the leading cause of cancer-related deaths, and ferroptosis has emerged as a potential therapeutic target due to its role in tumor suppression. RSL3, a GPX4 inhibitor, and NADK knockdown both promote ferroptosis, but their relationship in lung cancer treatment remains unexplored.
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Lung cancer remains the leading cause of cancer-related deaths, and ferroptosis has emerged as a potential therapeutic target due to its role in tumor suppression. RSL3, a GPX4 inhibitor, and NADK knockdown both promote ferroptosis, but their relationship in lung cancer treatment remains unexplored.
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