Results 151 to 160 of about 2,008 (163)

Identification and Functional Analysis of the NADK Gene Family in Wheat

Plant Molecular Biology Reporter, 2015
NAD(H) kinase (NADK) is a key enzyme for maintaining the cellular NAD(H)/NADP(H) balance and for NADP(H)-based metabolic pathways. We identified four NADK homologs, NADK1–4, from three major cereal crops, wheat, rice and maize, based on their phylogenetic relationships and gene structures.
Xiang Wang, Wen-Yan Li, Mao-Mao Zhang, Yin-Tao Gao, Wen-Ting Liu, Wen-Qiang Li, Izhar Muhammad, Kun-Ming Chen   +7 more
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Cytosolic NADK is conditionally essential for folate-dependent nucleotide synthesis

Nature Metabolism
Nicotinamide adenine dinucleotide kinase (NADK) catalyses the phosphorylation of NAD+ to produce NAD phosphate, the oxidized form of NADPH, a cofactor that serves a critical role in driving reductive metabolism. Cancer cells co-express two distinct NAD kinases that differ by localization (NADK, cytosol; NADK2, mitochondria).
Kyle M. Flickinger, Carlos A. Mellado Fritz, Kimberly S. Huggler, Gina M. Wade, Gavin R. Chang, Kathryn C. Fox, Judith A. Simcox, Jason R. Cantor   +7 more
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NADK-mediated proline synthesis enhances high-salinity tolerance in the razor clam

Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology
Euryhaline organisms can accumulate organic osmolytes to maintain osmotic balance between their internal and external environments. Proline is a pivotal organic small molecule and plays an important role in osmoregulation that enables marine shellfish to tolerate high-salinity conditions. During high-salinity challenge, NAD kinase (NADK) is involved in
Ruiqi, Liu, Min, Deng, Na, Zhang, Yifeng, Li, Liang, Jia, Donghong, Niu   +5 more
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Schisandra total lignans ameliorate neuronal ferroptosis in 3xTg-AD mice via regulating NADK/NADPH/GSH pathway

Phytomedicine
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with limited treatments. Schisandra total lignans (STL), the primary active component of Schisandra chinensis, shows potential in alleviating AD-related symptoms, though the mechanisms remain unclear.Considering the promoting effect of neuronal ferroptosis on AD and the ...
Yuying Wu, Mengying Wei, Mengyao Wang, Minsong Guo, Hengyuan Yu, Yong Chen, Tengfei Xu, Yuan Zhou   +7 more
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Abstract 1800: Cytosolic NADK is conditionally essential for folate-dependent nucleotide synthesis in human cells

Cancer Research
Abstract The genes that are required for the growth of mammalian cells can depend on an interplay of cell-intrinsic factors and environmental context. However, there is often little investigation into how nutrient availability impacts gene essentiality. Moreover, efforts such as DepMap have catalogued genes that contribute to cancer cell
Kyle M. Flickinger, Kimberly S. Huggler, Jason R. Cantor   +2 more
openaire   +1 more source

NUAK1-Mediated Phosphorylation of NADK Mitigates ROS Accumulation to Promote Osimertinib Resistance in Non–Small Cell Lung Carcinoma

Cancer Research
Abstract Osimertinib, a third generation epidermal growth factor receptor tyrosine kinase inhibitor, is approved as a first-line therapy in patients with advanced non–small cell lung carcinoma (NSCLC) with EGFR-activating mutations or the T790M resistance mutation.
Wei Lin, Na Wang, Shihao Wu, Mingxin Diao, Quanfu Huang, Kuo Li, Peiyuan Mei, Xiaojun Wang, Yongde Liao, Yunchong Meng   +9 more
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Palmitoylation-dependent activation of NADK promotes NADP⁺ synthesis and tumorigenesis

Abstract NAD kinase (NADK) is the sole cytosolic enzyme that catalyzes the synthesis of nicotinamide adenine dinucleotide phosphate (NADP+) from NAD+. NADP+ is essential for anabolic reactions and redox balance. Here, we show that palmitate facilitates NADP+ synthesis by enhancing NADK palmitoylation and activity.
Luojun Chen, Wanjun Zhang, Yue Zhu, Xiaoke Xing, Yi Yao, Huadong Pei, Yali Chen, Weijie Qin, Pingfeng Zhang   +8 more
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Investigation of the Relationship Between NADK and RSL3 and Exploration of Potential Usage of RSL3: Potential Applications of RSL3: Insights from Its Relationship with NADK

Theoretical and Natural Science
Lung cancer remains the leading cause of cancer-related deaths, and ferroptosis has emerged as a potential therapeutic target due to its role in tumor suppression. RSL3, a GPX4 inhibitor, and NADK knockdown both promote ferroptosis, but their relationship in lung cancer treatment remains unexplored.
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Selective inhibition of nicotinamide adenine kinases (NADKs) by compact NAD mimics

2009
We have examined sequence diversity of 147 co-crystal structures of proteins utilizing NAD as a cofactor or as a substrate. Most of these proteins bind NAD in an extended conformations. However, there are clear exceptions to this general trend. Several bacterial reductases bind NAD in an extremely folded conformations.
PETRELLI, Riccardo, Felczak K, Chen L, VITA, PATRIZIA, CAPPELLACCI, Loredana, FRANCHETTI, Palmarisa, GRIFANTINI, Mario, Di Stefano M, Magni G, Pankiewicz K.   +9 more
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Synthesis and Enzymatic Evaluation of NAD Mimics as Nicotinamide Adenine Dinucleotide Kinase (NADK) Inhibitors

2011
NAD kinase (NADK) is a key enzyme that regulates supply of NADP in the cell. At this time no other pathway of NADP biosynthesis has been found in prokaryotic or eukaryotic cells. Human NAD kinase catalyzes a magnesium- dependent phosphorylation of the 2’-hydroxyl group of the adenosine ribose moiety of NAD using ATP as phosphoryl donor to give NADP ...
CAPPELLACCI, Loredana, PETRELLI, Riccardo, Krzysztof Felczak, VITA, PATRIZIA, TORQUATI, ILARIA, Palmarisa Franchetti, Michele Di Stefano, Giulio Magni, Mario Grifantini, Krzysztof W. Pankiewicz   +9 more
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