Results 51 to 60 of about 10,930 (224)

PANX2 Suppresses Lung Adenocarcinoma Progression by Inducing Disulfidptosis and Enhancing Antitumor Immunity

Advanced Science, EarlyView.
ABSTRACT Lung adenocarcinoma (LUAD) remains a leading cause of cancer mortality with limited therapeutic options. Disulfidptosis, a novel cell death modality driven by disulfide stress, represents a promising target, yet its regulation in LUAD is poorly defined. Here, we identify Pannexin 2 (PANX2) as a tumor suppressor in LUAD.
Yi Chen, Zhao‐Yu Liu, Gao‐Wen Qu, Run‐Hao Zeng, Wen‐Xia Yao, Yong‐Bing Zhou, Xue Liang, Yu‐Xiong Lai   +7 more
wiley   +1 more source

Regulation of the expression of NADP-malic enzyme by UV-B, red and far-red light in maize seedlings

Brazilian Journal of Medical and Biological Research, 1999
The induction of nicotinamide adenine dinucleotide phosphate-malic enzyme (NADP-ME) in etiolated maize (Zea mays) seedlings by UV-B and UV-A radiation, and different levels of photosynthetically active radiation (PAR, 400-700 nm) was investigated by ...
P. Casati, M.F. Drincovich, G.E. Edwards, C.S. Andreo   +3 more
doaj   +1 more source

Plastidial NADP-malic enzymes from grasses: Unraveling the way to the C4 specific isoforms [PDF]

Plant Physiology and Biochemistry, 2013
Malic enzyme is present in many plant cell compartments such as plastids, cytosol and mitochondria. Particularly relevant is the plastidial isoform that participates in the C(4) cycle providing CO(2) to RuBisCO in C(4) species. This type of photosynthesis is more frequent among grasses where anatomical preconditioning would have facilitated the ...
Saigo, Mariana, Alvarez, Clarisa Ester, Andreo, Carlos Santiago, Drincovich, Maria Fabiana   +3 more
openaire   +3 more sources

Ferritinophagy Rewires Carnitine‐Dependent Lipid Metabolism to Inhibit PRRSV and IAV Replication

Advanced Science, EarlyView.
NCOA4‐mediated ferritinophagy reprograms carnitine metabolism by disrupting Fe‐S cluster biogenesis, thereby establishing an iron‐lipid axis that suppresses various viruses, including PRRSV and IAV. However, viruses counteract this mechanism by degrading NCOA4.
Kaifeng Guan, Chenyang Yuan, Zekun Meng, Yanan Wang, Xueying Zhai, Chunjie Huang, Xiang Zhou, Gaiping Zhang   +7 more
wiley   +1 more source

Effect of cadmium and glutathione on malic enzyme activity in brown shrimps (Crangon crangon) from the Gulf of Gdańsk

Oceanologia, 2011
The high level of cadmium in the abdominal muscle of the brown shrimp Crangon crangon is due to the serious pollution of the water in the Gulf of Gdansk. The inhibition of malic enzyme (ME) activity by cadmium, and in consequence the reduced formation of
Edward F. Skorkowski, Piotr Stepnowski, Adriana Mika, Anna Białk-Bielińska, Natalia Niedźwiecka   +4 more
doaj  

Laying the Foundation for Crassulacean Acid Metabolism (CAM) Biodesign: Expression of the C4 Metabolism Cycle Genes of CAM in Arabidopsis

Frontiers in Plant Science, 2019
Crassulacean acid metabolism (CAM) is a specialized mode of photosynthesis that exploits a temporal CO2 pump with nocturnal CO2 uptake and concentration to reduce photorespiration, improve water-use efficiency (WUE), and optimize the adaptability of ...
Sung Don Lim, Sojeong Lee, Won-Gyu Choi, Won Cheol Yim, John C. Cushman   +4 more
doaj   +1 more source

Purification and Characterization of the NADP-Malic Enzyme fromBradyrhizobium japonicumA1017

Bioscience, Biotechnology, and Biochemistry, 1997
An NADP-malic enzyme [EC 1.1.1.40] was purified to homogeneity from Bradyrhizobium japonicum A1017, and the molecular and physiological characteristics were surveyed. The molecular mass of one subunit of the purified enzyme was evaluated to be 77,600 Da by SDS-PAGE, and the native enzyme was a tetramer in pH 7.0 and dimer in pH 8.0 conditions, showing ...
CHEN, Fan, OKABE, Youichi, OSANO, Kaoru, TAJIMA, Shigeyuki   +3 more
openaire   +2 more sources

Electroenzymatic CO2 Fixation

Angewandte Chemie International Edition, EarlyView.
Electroenzymatic CO2 fixation enables energy‐efficient, highly selective synthesis of complex molecules. Unlocking its full potential requires fundamental understanding of electrode‐coupled reductases and carboxylases. This review critically discusses available enzymes, product scope, and key thermodynamic and kinetic considerations, highlighting ...
Leonardo Castañeda‐Losada, Michael Richter, Christophe Léger, Vincent Fourmond, Nicolas Plumeré   +4 more
wiley   +1 more source

Auxin is involved in arbuscular mycorrhizal fungi-promoted tomato growth and NADP-malic enzymes expression in continuous cropping substrates

BMC Plant Biology, 2021
Background Despite significant limitations of growth medium reuse, a large amount of organic substrate is reused in soilless cultivation of horticultural crops in China. Arbuscular mycorrhizal fungi (AMF) can promote nutrient absorption and improve plant
Yu Wang, Wenze Zhang, Weikang Liu, Golam Jalal Ahammed, Wenxu Wen, Shirong Guo, Sheng Shu, Jin Sun   +7 more
doaj   +1 more source

A nanoplatform that induces dual‐amino acid deprivation to reverse tumor immunosuppression and enhance metabolic immunotherapy

BMEMat, EarlyView.
ZIF‐8‐based nanoparticles co‐delivering CB‐839 (glutaminase inhibitor) and 1‐MT (IDO1 inhibitor), dual‐targeting glutamine/tryptophan metabolism to induce immunogenic cell death, activate STING, block kynurenine production, reverse immunosuppression, and enhance cancer immunotherapy to suppress primary/distant tumors.
Wenli Ning, Yunhan Sun, Mingyang Li, Shilu Liu, Fangjie Yi, Hongfei Wang, Ruibing Bai, Dongdong Liu, Fen Zhao, Guiqiang Zhang, Xiao Fu   +10 more
wiley   +1 more source