Results 121 to 130 of about 56,952 (277)

Maternal Lead Exposure Induces Glandular Alterations in the Salivary Glands of Rat Male Offspring

Environmental Toxicology, EarlyView.
ABSTRACT Lead (Pb) is a widely distributed environmental pollutant that is highly noxious due to its toxicokinetic characteristics. Pb exposure can damage vital organ systems, including the central nervous and stomatognathic systems. As salivary glands play an important role in oral homeostasis, this study aimed to investigate the effects of maternal ...
Rayssa Maitê Farias Nazário, Deiweson Souza‐Monteiro, Walessa Alana Bragança Aragão, Luciana Eiró‐Quirino, Leonardo Oliveira Bittencourt, Raquel Fernanda Gerlach, Antônio Hernandes Chaves‐Neto, Michael Aschner, Rafael Rodrigues Lima   +8 more
wiley   +1 more source

The cosubstrate NADP(H) protects lysine 601 in the porcine NADPH-cytochrome P-450 reductase against pyridoxylation

, 1990
Lys601 in NADPH-cytochrome P-450 reductase is modified by reductive alkylation with pyridoxal 5'-phosphate (pyridoxylation). Lys601 is protected against modification by the cosubstrate NADP(H)
Müller, Karin, Karin Müller, Linder, Dietmar, Ludwig Lumper, Dietmar Linder, Lumper, Ludwig   +5 more
core   +1 more source

It started off as a Cys, how did it end up like this? Identifying the extent of unmodelled oxidatively modified cysteines within the Protein Data Bank

Acta Crystallographica Section D, EarlyView.
This work examines data contained within 118 215 structures in the Protein Data Bank for unmodelled difference density concomitant with unmodelled oxidatively damaged cysteines. This analysis demonstrates that site‐specific oxidation of residues is a phenomenon of which the experimenter should be aware, and highlights the need for a suitable detection ...
Samuel P. Foster, Anna J. Warren, C. Alistair Siebert, Jaswir Basran, Peter C. E. Moody   +4 more
wiley   +1 more source

NADK Governs Ferroptosis Susceptibility by Orchestrating NADPH Homeostasis

Antioxidants
Ferroptosis, a regulated cell death pathway driven by iron-dependent lipid peroxidation, is modulated by cellular antioxidant systems, particularly the glutathione (GSH)–glutathione peroxidase 4 (GPX4) axis.
Xinyi Chen, Yingying Zhang, Dandan Song, Fei Gui, Yuejia Cao, Yu Hong, Rong Chen, Yang Song, Chunhong Di, Jun Yang, Xiaohua Tan   +10 more
doaj   +1 more source

A Nanoconfined Four-Enzyme Cascade Simultaneously Driven by Electrical and Chemical Energy, with Built-in Rapid, Confocal Recycling of NADP(H) and ATP. [PDF]

ACS Catal, 2022
Megarity CF, Weald TRI, Heath RS, Turner NJ, Armstrong FA.   +4 more
europepmc   +1 more source

Molecular architecture of the human citrate synthase–malate dehydrogenase 2 metabolon

Acta Crystallographica Section D, EarlyView.
Human malate dehydrogenase forms a transient complex with citrate synthase.Metabolons are transient biomolecular complexes that enhance the efficiency of metabolic pathways through substrate channeling. These complexes are difficult to study because of their transient nature, thus limiting our understanding of how they are formed and regulated.
Angela J. Kayll, Umanga Rupakheti, Renee St John, Gabriel Rementeria, Joseph J. Provost, Christopher E. Berndsen   +5 more
wiley   +1 more source

Structural basis of regioselective double halogenation of the β‐carboline tryptoline by the single‐component halogenase AetF

Acta Crystallographica Section D, EarlyView.
A structure of the flavin‐dependent single‐component tryptophan halogenase AetF bound to the non‐native tricyclic substrate tryptoline reveals a binding pose analogous to l‐tryptophan that directs C6‐first halogenation. Product analysis identifies 6,8‐dibromotryptoline as the final product.Flavin‐dependent halogenases (FDHs) offer a biocatalytic route ...
Simon Bork, Hendrik J. Horstmeier, Bjarne Scharkowski, Hartmut H. Niemann   +3 more
wiley   +1 more source

Isolation of a cotton NADP(H) oxidase homologue induced by drought stress

Pesquisa Agropecuária Brasileira, 2000
The aim of this study was to identify and isolate genes that are differentially expressed in four selected cotton (Gossypium hirsutum L.) genotypes contrasting according to their tolerance to water deficit.
NEPOMUCENO ALEXANDRE LIMA, STEWART JAMES MCD, OOSTERHUIS DERRICK, TURLEY RICKIE, NEUMAIER MORMAN, FARIAS JOSÉ RENATO BOUÇAS   +5 more
doaj  

In vitro and in vivo metabolism profiles of cathinone and pseudoephedrine: Discrimination between khat and pseudoephedrine uses

Journal of Forensic Sciences, EarlyView.
Abstract In the present study, the metabolism of khat (Catha edulis) and pseudoephedrine was compared with the aim of identifying objective criteria that could be used to discriminate between them for forensic and doping‐control purposes. An in vitro study using human liver microsomes and an in vivo study using rat urine were performed under harmonized
Jong Suk Park, Jun Sang Yu, Yejin Kim, Hee Seung Kim, Jae Chul Cheong, Jin Young Kim, Hye Hyun Yoo   +6 more
wiley   +1 more source

A conformational change in the isolated NADP(H)-binding component (dIII) of transhydrogenase induced by low pH: a reflection of events during proton translocation by the complete enzyme?

, 2002
Transhydrogenase couples the reduction of NADP+ by NADH to inward proton translocation across the bacterial (or mitochondrial) membrane. Conformational changes in the NADP(H)-binding component of the enzyme (dIII) are central to the coupling mechanism ...
Rodrigues, Daniel, Jackson, J.Baz, Rodrigues, Daniel J, Jackson, John   +3 more
core   +1 more source