Results 171 to 180 of about 11,248,301 (236)
Abstract B‐vitamins are organic cofactors required by prokaryotic and eukaryotic planktonic cells; their availability impacts aquatic microbial communities and associated biogeochemistry. Despite their ecological importance, B‐vitamin dynamics and their relationships to plankton composition in estuaries are unclear, limiting our understanding of ...
Meriel J. Bittner +6 more
wiley +1 more source
Neurocardiology: Brain–Heart Interactions in the Heart
The heart and brain maintain systemic homeostasis through bidirectional communication involving neural, biochemical, and mechanical pathways. Dysregulation of these pathways contributes to a spectrum of conditions involving heart–brain interactions, including Takotsubo syndrome, the epileptic heart, stroke–heart syndrome, heart failure, cardiac ...
Wentao Wang +3 more
wiley +1 more source
Depletion of NADP(H) due to CD38 activation triggers endothelial dysfunction in the postischemic heart. [PDF]
Reyes LA +8 more
europepmc +1 more source
Ergothioneine: Biosynthesis, Molecular Mechanisms, Physiological Function, and Role in Disease
Ergothioneine is a natural thione antioxidant with significant biomedical potential. By reducing oxidative stress, inflammation, mitochondrial dysfunction, and cellular injury, ergothioneine may support interventions for aging‐related disorders, neurodegeneration, metabolic diseases, and skin protection.
Guojuan Yi +6 more
wiley +1 more source
Using multi‐omics techniques, including proteomics, targeted metabolomics, and structural proteomics, we observed that the early stage of Alzheimer's disease (AD) progression was accompanied by mitochondrial dysfunction aggravation, the entry of excessive Aβ into the mitochondria, and the co‐aggregation of Aβ and Me3 protein, thus inducing ...
Wenjie Zhu +5 more
wiley +1 more source
IDH mutation is an important event in hematological malignancies. This review systematically integrates the basic mechanism of IDH mutations and combines it with the clinical translation of related research progress. It also discusses the application strategies of IDH inhibitors and feasible research directions, with the aim of providing a theoretical ...
Jinkun Xu, Haiying Bai, Lijuan Hu
wiley +1 more source
Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K +5 more
wiley +1 more source
Patients with alcohol‐associated liver cirrhosis or acetaminophen (APAP) toxicity frequently develop anemia with iron metabolism disturbances. Dysregulation of hepcidin–ferroportin signaling, along with inflammation, oxidative stress, hypoxia, impaired intestinal iron absorption, malnutrition, and gastrointestinal bleeding, contributes to anemia ...
Debabrata Dash, Raj Kumar Koiri
wiley +1 more source
Cloning, Expression and Characterization of NAD Kinase from Staphylococcus aureus Involved in the Formation of NADP (H): A Key Molecule in the Maintaining of Redox Status and Biofilm Formation. [PDF]
Prasad UV +7 more
europepmc +1 more source

