Results 71 to 80 of about 182,746 (311)
Advanced Science, EarlyView.Spatially resolved Shewanella–acetogen interactions link DIET and MET pathways to acetate formation, offering a generalizable framework for designing structured, high‐efficiency microbial electrosynthesis systems. Abstract Precise manipulation of interspecies electron transfer (IET) is critical for advancing microbial electrosynthesis (MES) toward ...
Jing Zhang +8 more
wiley +1 more source
Advanced Science, EarlyView.Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang +12 more
wiley +1 more source
Measuring the rate of NADPH consumption by glutathione reductase in the cytosol and mitochondria.
PLoS ONEBackgroundNADPH is an essential co-factor supporting the function of enzymes that participate in both inflammatory and anti-inflammatory pathways in myeloid cells, particularly macrophages.
Kenneth K Y Ting +5 more
doaj +1 more source
RNA‐Interference Approach to Study Functions of NADPH : Cytochrome P450 Oxidoreductase in Human Hepatocytes [PDF]
, 2009 Diana M. Feidt +3 more
openalex +1 more source
Advanced Science, EarlyView.This study reveals that XBP1s drives production of circTspan3, a circular RNA that strengthens cartilage by boosting anabolic activity and limiting cell death. Phosphorylated ANXA2 directs circTspan3 into exosomes, enabling paracrine repair. Exosomal circTspan3 expands growth‐plate cartilage and promotes in vivo regeneration, highlighting its promise ...
Yiming Pan +16 more
wiley +1 more source
Differential role for ERK1/2 and p38 MAP kinases in activating NADPH-oxidase and phospholipase A2 in angiotensin II-stimulated phagocytes [PDF]
, 2002 I HAZANHALLEVY
openalex +1 more source
Advanced Science, EarlyView.Discover a groundbreaking mediator‐free photocatalytic method for coenzyme NAD(P)H regeneration using BiOBr nanosheets in a microfluidic chip. This study achieves 100% NAD+ to NADH conversion in 126 s, maintaining >87% efficiency over 32 h. Explore how photocatalysis and microfluidics combine to offer a sustainable, scalable solution for green ...
Yao Chai +13 more
wiley +1 more source
Regulation of FSP1 myristoylation by NADPH: A novel mechanism for ferroptosis inhibition
Redox BiologyExcitotoxicity is a prevalent pathological event in neurodegenerative diseases. The involvement of ferroptosis in the pathogenesis of excitotoxicity remains elusive.
Na Liu +10 more
doaj +1 more source
Advanced Science, EarlyView.This study develops a biomimetic nanoplatform using erythrocyte membrane‐camouflaged, CD144 antibody‐functionalized nanoparticles to deliver 2‐deoxy‐D‐ribose (2dDR). This system promotes heart valve endothelialization by enhancing endothelial cell migration and proliferation via EGFR activation, while improving hemocompatibility.
Xiang Qiu +11 more
wiley +1 more source
Journal of Advanced ResearchIntroduction: Lenvatinib is the first-line therapy of hepatocellular carcinoma (HCC) and the high frequency of lenvatinib resistance hinders the improvement of HCC treatment. Since NADPH plays vital roles in antioxidant defense and reductive biosynthesis,
Yang Hu +10 more
doaj +1 more source