Results 21 to 30 of about 832 (217)
The Role of Mitochondrial NADPH-Dependent Isocitrate Dehydrogenase in Cancer Cells [PDF]
International Journal of Cell Biology, 2012 Isocitrate dehydrogenase 2 (IDH2) is located in the mitochondrial matrix. IDH2 acts in the forward Krebs cycle as an NADP+-consuming enzyme, providing NADPH for maintenance of the reduced glutathione and peroxiredoxin systems and for self-maintenance by reactivation of cystine-inactivated IDH2 by glutaredoxin 2. In highly respiring cells, the resulting
Katarína Smolková, Petr Ježek
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Computational design of highly stable and soluble alcohol dehydrogenase for NADPH regeneration [PDF]
Bioresources and Bioprocessing, 2021 Abstract Nicotinamide adenine dinucleotide phosphate (NADPH), as a well-known cofactor, is widely used in the most of enzymatic redox reactions, playing an important role in industrial catalysis. However, the absence of a comparable method for efficient NADP + to NADPH ...
Jinling Xu +7 more
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Bioresources and Bioprocessing, 2022 NADPH provides the reducing power for decomposition of reactive oxygen species (ROS), making it an indispensable part during ROS defense. It remains uncertain, however, if living cells respond to the ROS challenge with an elevated intracellular NADPH ...
Jingyi Li +7 more
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The Binding of NADH and NADPH to Bovine‐Liver Glutamate Dehydrogenase [PDF]
European Journal of Biochemistry, 1982 The binding of NADH and NADPH to bovine liver glutamate dehydrogenase has been studied using circular dichroism (CD) and fluorescence spectroscopy, under comparable conditions of enzyme concentration. Spectroscopic titrations have been analysed using non‐linear least‐squares techniques to determine dissociation constants and parameters for the ...
J M, Delabar, S R, Martin, P M, Bayley
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Journal of Lipid Research, 1970 Lipid synthesis from acetate-1-14C by rat skin was inhibited 44-56% by 2.5 × 10-4m dehydroepiandrosterone (DHA) in vitro with or without addition of glucose in the incubation medium. This inhibition affected all the lipid fractions examined (hydrocarbons,
Vincent A. Ziboh, M.A. Dreize, S.L. Hsia
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Glucose‐6‐phosphate dehydrogenase, NADPH, and cell survival [PDF]
IUBMB Life, 2012 AbstractGlucose‐6‐phosphate dehydrogenase (G6PD) is the rate‐limiting enzyme of the pentose phosphate pathway. Many scientists think that the roles and regulation of G6PD in physiology and pathophysiology have been well established as the enzyme was first identified 80 years ago.
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Microbial Cell Factories, 2005 Background One of the most fascinating properties of the biotechnologically important organism Saccharomyces cerevisiae is its ability to perform simultaneous respiration and fermentation at high growth rate even under fully aerobic conditions.
Wittmann Christoph, Frick Oliver
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The Ca2+-Regulation of the Mitochondrial External NADPH Dehydrogenase in Plants Is Controlled by Cytosolic pH. [PDF]
PLoS ONE, 2015 NADPH is a key reductant carrier that maintains internal redox and antioxidant status, and that links biosynthetic, catabolic and signalling pathways.
Meng-Shu Hao +4 more
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Biomolecules, 2023 Thorough study of composition and fluorescence properties of a commercial reagent of active equine NAD-dependent alcohol dehydrogenase expressed and purified from E. coli has been carried out. Several experimental methods: spectral- and time-resolved two-
Ioanna A. Gorbunova +6 more
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The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression
Hepatology, EarlyView., 2022 Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro +14 more
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