Results 31 to 40 of about 832 (217)

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source

The NADPH metabolic network regulates human αB-crystallin cardiomyopathy and reductive stress in Drosophila melanogaster. [PDF]

PLoS Genetics, 2013
Dominant mutations in the alpha-B crystallin (CryAB) gene are responsible for a number of inherited human disorders, including cardiomyopathy, skeletal muscle myopathy, and cataracts.
Heng B Xie, Anthony Cammarato, Namakkal S Rajasekaran, Huali Zhang, Jennifer A Suggs, Ho-Chen Lin, Sanford I Bernstein, Ivor J Benjamin, Kent G Golic   +8 more
doaj   +1 more source

Efficicent (R)-phenylethanol production with enantioselectivity-alerted (S)-carbonyl reductase II and NADPH regeneration.

PLoS ONE, 2013
The NADPH-dependent (S)-carbonyl reductaseII from Candida parapsilosis catalyzes acetophenone to chiral phenylethanol in a very low yield of 3.2%. Site-directed mutagenesis was used to design two mutants Ala220Asp and Glu228Ser, inside or adjacent to the
Rongzhen Zhang, Botao Zhang, Yan Xu, Yaohui Li, Ming Li, Hongbo Liang, Rong Xiao   +6 more
doaj   +1 more source

REGULATION OF GLUCOSE-6-PHOSPHATE DEHYDROGENASE IN PLANTS (REVIEW ARTICLE) [PDF]

Journal of Plant Production, 2011
The  regulation of G6PDH has been studied in plants, eukaryotic algae and cyanobacteria, but the gene encoding G6PDH has been isolated from only a few of these sources.
S. Gyulakhmedov, A. Kuliyev, A. Elhefny
doaj   +1 more source

Quantifying NAD(P)H production in the upper Entner–Doudoroff pathway from Pseudomonas putida KT2440

FEBS Open Bio, 2015
Despite the lack of biochemical information, all available in silico metabolic models of Pseudomonas putida KT2440 consider NADP as the only cofactor accepted by the glucose‐6‐phosphate dehydrogenases.
Karel Olavarria, Marina Pupke Marone, Henrique da Costa Oliveira, Juan Camilo Roncallo, Fernanda Nogales da Costa Vasconcelos, Luiziana Ferreira da Silva, José Gregório Cabrera Gomez   +6 more
doaj   +1 more source

Engineering Cofactor Specificity of a Thermostable Phosphite Dehydrogenase for a Highly Efficient and Robust NADPH Regeneration System

Frontiers in Bioengineering and Biotechnology, 2021
Nicotinamide adenine dinucleotide phosphate (NADP)-dependent dehydrogenases catalyze a range of chemical reactions useful for practical applications. However, their dependence on the costly cofactor, NAD(P)H remains a challenge which must be addressed ...
Gamal Nasser Abdel-Hady, Gamal Nasser Abdel-Hady, Takeshi Ikeda, Takeshi Ikeda, Takenori Ishida, Takenori Ishida, Hisakage Funabashi, Hisakage Funabashi, Akio Kuroda, Akio Kuroda, Ryuichi Hirota, Ryuichi Hirota   +11 more
doaj   +1 more source

Engineering Nanoplatforms for Alzheimer's Disease Detection via Biomolecular Corona Proteomic and Lipidomic Profiling

Advanced Healthcare Materials, EarlyView.
Engineered nanoparticles capture disease‐specific biomolecular coronas that uncover hidden molecular features of Alzheimer's disease. Combined proteomic and lipidomic analyses reveal a characteristic shift in ribosomal machinery and energy metabolism, generating a multiomic fingerprint that supports accurate disease detection and opens new ...
Antonietta Greco, Roberto Baretta, Andrea Di Fonzo, Andrea Armirotti, Stefano Cinti, Mara Mirasoli, Marco Frasconi, Claudia Corbo   +7 more
wiley   +1 more source

NADPH Dehydrogenase Gene Regulates Energy Distribution and Fatty Acid Metabolism During Fruiting Body Formation in the Filamentous Fungus Podospora anserina

Microbial Biotechnology
Nicotinamide adenine dinucleotide phosphate (NADPH) dehydrogenase is an oxidoreductase involved in many physiological processes and metabolic pathways. However, its role in filamentous fungal physiology is still unclear.
Yanling Qiu, Amechi S. Nwankwegu, Yue Sun, Yuanjing Li, Weizhao Chen, Gang Liu, Ning Xie   +6 more
doaj   +1 more source

METABOLIC PLATELET STATUS IN PATIENTS WITH STABLE ANGINA

Российский кардиологический журнал, 2013
Aim. To study the activity of NAD- and NADP-dependent platelet dehydrogenases in patients with various functional classes of angina. Material and methods. The study included 91 men with Functional Class II–IV angina, aged 45–72 years. In all participants,
I. Yu. Grinstein, A. A. Savchenko, E. A. Savchenko, A. A. Kosinova, Yu. I. Grinstein   +4 more
doaj   +1 more source

A novel strategy involved in [corrected] anti-oxidative defense: the conversion of NADH into NADPH by a metabolic network. [PDF]

PLoS ONE, 2008
The reduced nicotinamide adenine dinucleotide phosphate (NADPH) is pivotal to the cellular anti-oxidative defence strategies in most organisms. Although its production mediated by different enzyme systems has been relatively well-studied, metabolic ...
Ranji Singh, Joseph Lemire, Ryan J Mailloux, Vasu D Appanna   +3 more
doaj   +1 more source