Results 1 to 10 of about 95,385 (310)

ROS Signaling and NADPH Oxidase in Red Algae [PDF]

Antioxidants
We explore the diverse roles of reactive oxygen species (ROS) and NADPH oxidases in red algae, focusing on their involvement in fertilization, wound repair, stress adaptation, and development.
Gwang-Hoon Kim, Eunyoung Shim, Giuseppe C. Zuccarello   +2 more
doaj   +2 more sources

A role for NADPH oxidase in antigen presentation [PDF]

Frontiers in Immunology, 2013
The nicotinamide adenine dinucleotide phosphate (NADPH) oxidase expressed in phagocytes is a multi-subunit enzyme complex that generates superoxide (O2.-).
Gail J Gardiner, Sarah N Deffit, Shawna eMcLetchie, Liliana ePérez, Crystal C Walline, Janice S Blum   +5 more
doaj   +3 more sources

NoxO1 Determines the Level of ROS Formation by the Nox1-Centered NADPH Oxidase [PDF]

Antioxidants
The Nox1-centered NADPH oxidase complex facilitates the transfer of electrons from intracellular NADPH across the cell membrane to extracellular molecular oxygen, resulting in the formation of superoxide.
Dana Maureen Hebchen, Manuela Spaeth, Niklas Müller, Katrin Schröder   +3 more
doaj   +2 more sources

NADPH oxidase limits innate immune responses in the lungs in mice. [PDF]

PLoS ONE, 2010
Chronic granulomatous disease (CGD), an inherited disorder of the NADPH oxidase in which phagocytes are defective in generating superoxide anion and downstream reactive oxidant intermediates (ROIs), is characterized by recurrent bacterial and fungal ...
Brahm H Segal, Wei Han, Jennifer J Bushey, Myungsoo Joo, Zahida Bhatti, Joy Feminella, Carly G Dennis, R Robert Vethanayagam, Fiona E Yull, Maegan Capitano, Paul K Wallace, Hans Minderman, John W Christman, Michael B Sporn, Jefferson Chan, Donald C Vinh, Steven M Holland, Luigina R Romani, Sarah L Gaffen, Michael L Freeman, Timothy S Blackwell   +20 more
doaj   +1 more source

Myeloid-derived suppressor cells modulate immune responses independently of NADPH oxidase in the ovarian tumor microenvironment in mice. [PDF]

PLoS ONE, 2013
The phagocyte NADPH oxidase generates superoxide anion and downstream reactive oxidant intermediates in response to infectious threat, and is a critical mediator of antimicrobial host defense and inflammatory responses.
Heidi E Godoy, A Nazmul H Khan, R Robert Vethanayagam, Melissa J Grimm, Kelly L Singel, Nonna Kolomeyevskaya, Kevin J Sexton, Anupama Parameswaran, Scott I Abrams, Kunle Odunsi, Brahm H Segal   +10 more
doaj   +1 more source

Implication of Nicotinamide Adenine Dinucleotide Phosphate (NADPH) Oxidase and Its Inhibitors in Alzheimer’s Disease Murine Models

Antioxidants, 2021
Alzheimer’s disease (AD) is one of the main human dementias around the world which is constantly increasing every year due to several factors (age, genetics, environment, etc.) and there are no prevention or treatment options to cure it.
Leticia Guadalupe Fragoso-Morales, José Correa-Basurto, Martha Cecilia Rosales-Hernández   +2 more
doaj   +1 more source

Role of NADPH oxidase versus neutrophil proteases in antimicrobial host defense. [PDF]

PLoS ONE, 2011
NADPH oxidase is a crucial enzyme in mediating antimicrobial host defense and in regulating inflammation. Patients with chronic granulomatous disease, an inherited disorder of NADPH oxidase in which phagocytes are defective in generation of reactive ...
R Robert Vethanayagam, Nikolaos G Almyroudis, Melissa J Grimm, David C Lewandowski, Christine T N Pham, Timothy S Blackwell, Ruta Petraitiene, Vidmantas Petraitis, Thomas J Walsh, Constantin F Urban, Brahm H Segal   +10 more
doaj   +1 more source

Pro-Resolving FPR2 Agonists Regulate NADPH Oxidase-Dependent Phosphorylation of HSP27, OSR1, and MARCKS and Activation of the Respective Upstream Kinases

Antioxidants, 2021
Background: Formyl peptide receptor 2 (FPR2) is involved in the pathogenesis of chronic inflammatory diseases, being activated either by pro-resolving or proinflammatory ligands.
Rosario Ammendola, Melania Parisi, Gabriella Esposito, Fabio Cattaneo   +3 more
doaj   +1 more source

Pharmacological and genetic inhibition of NADPH oxidase does not reduce brain damage in different models of perinatal brain injury in newborn mice

Neurobiology of Disease, 2008
Background: Inflammation and reactive oxygen species (ROS) are important in the development of perinatal brain injury. The ROS-generating enzyme NADPH oxidase (Nox2) is present in inflammatory cells and contributes to brain injury in adult animal models.
Christina Doverhag, Matthias Keller, Anna Karlsson, Maj Hedtjarn, Ulf Nilsson, Edith Kapeller, Gergely Sarkozy, Lars Klimaschewski, Christian Humpel, Henrik Hagberg, Georg Simbruner, Pierre Gressens, Karin Savman   +12 more
doaj   +1 more source

Skeletal muscle NADPH oxidase is increased and triggers stretch-induced damage in the mdx mouse. [PDF]

PLoS ONE, 2010
Recent studies have shown that oxidative stress contributes to the pathogenesis of muscle damage in dystrophic (mdx) mice. In this study we have investigated the role of NADPH oxidase as a source of the oxidative stress in these mice.
Nicholas P Whitehead, Ella W Yeung, Stanley C Froehner, David G Allen   +3 more
doaj   +1 more source