Implication of Nicotinamide Adenine Dinucleotide Phosphate (NADPH) Oxidase and Its Inhibitors in Alzheimer’s Disease Murine Models [PDF]
Antioxidants, 2021 Alzheimer’s disease (AD) is one of the main human dementias around the world which is constantly increasing every year due to several factors (age, genetics, environment, etc.) and there are no prevention or treatment options to cure it.
Leticia Guadalupe Fragoso-Morales +2 more
doaj +2 more sources
ROS Signaling and NADPH Oxidase in Red Algae [PDF]
AntioxidantsWe explore the diverse roles of reactive oxygen species (ROS) and NADPH oxidases in red algae, focusing on their involvement in fertilization, wound repair, stress adaptation, and development.
Gwang-Hoon Kim +2 more
doaj +2 more sources
Molecular Insights of p47phox Phosphorylation Dynamics in the Regulation of NADPH Oxidase Activation and Superoxide Production [PDF]
Journal of Biological Chemistry, 2014 Background: p47phox is a regulatory subunit of NADPH oxidase, which produces superoxide. Results: We propose a molecular dynamics model of p47phox phosphorylation and assembly with p22phox in NADPH oxidase activation supported by biochemical experiments.
Daniel N. Meijles +3 more
semanticscholar +2 more sources
eLife, 2017 Transient increases in mitochondrially-derived reactive oxygen species (ROS) activate an adaptive stress response to promote longevity. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases produce ROS locally in response to various stimuli, and ...
Collin Yvès Ewald +8 more
doaj +2 more sources
NADPH oxidase-dependent production of reactive oxygen species induces endoplasmatic reticulum stress in neutrophil-like HL60 cells. [PDF]
PLoS ONE, 2015 Reactive oxygen species (ROS) primarily produced via NADPH oxidase play an important role for killing microorganisms in neutrophils. In this study we examined if ROS production in Human promyelocytic leukemia cells (HL60) differentiated into neutrophil ...
Wilson Mitsuo Tatagiba Kuwabara +5 more
doaj +2 more sources
NADPH Oxidase 1 and Its Derived Reactive Oxygen Species Mediated Tissue Injury and Repair [PDF]
Oxidative Medicine and Cellular Longevity, 2014 Reactive oxygen species are mostly viewed to cause oxidative damage to various cells and induce organ dysfunction after ischemia-reperfusion injury. However, they are also considered as crucial molecules for cellular signal transduction in biology. NADPH
Xiujun Fu +5 more
semanticscholar +5 more sources
NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets
Nature Reviews Cardiology, 2019 Yixuan Zhang, Hua Cai
exaly +2 more sources
NoxO1 Determines the Level of ROS Formation by the Nox1-Centered NADPH Oxidase [PDF]
AntioxidantsThe Nox1-centered NADPH oxidase complex facilitates the transfer of electrons from intracellular NADPH across the cell membrane to extracellular molecular oxygen, resulting in the formation of superoxide.
Dana Maureen Hebchen +3 more
doaj +2 more sources
Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone. [PDF]
Journal of Clinical Investigation, 1996 S. Rajagopalan +6 more
semanticscholar +2 more sources
Oxidative Medicine and Cellular Longevity, 2021 NADPH oxidase as an important source of intracellular reactive oxygen species (ROS) has gained enormous importance over the years, and the detailed structures of all the isoenzymes of the NADPH oxidase family and their regulation have been well explored.
Upasana Ganguly +6 more
semanticscholar +1 more source