Results 111 to 120 of about 424,484 (404)

Mechanotransduction Activates Microglia and Impairs Phagocytosis in Stiff Amyloid‐β Plaques

Advanced Science, EarlyView.
The study constructs an in vitro Aβ plaque‐associated microglia model and uses SECM and SICM to in situ monitor changes in ROS levels, membrane permeability, and phagocytosis of microglia during Aβ clearance. It is found out that Aβ stiffness triggers microglial activation via the PIEZO1 mechanotransduction pathway, causing neuroinflammation and ...
Yulin Liu, Junjie Zhang, Yuxiang Zhao, Feixiang Fang, Siyu Zhang, Qiqi An, Jian Zhuang, Feng Xu, Fei Li   +8 more
wiley   +1 more source

Signaling pathways involved in renal oxidative injury: role of the vasoactive peptides and the renal dopaminergic system [PDF]

, 2014
The physiological hydroelectrolytic balance and the redox steady state in the kidney are accomplished by an intricate interaction between signals from extrarenal and intrarenal sources and between antinatriuretic and natriuretic factors.
Choi, Marcelo Roberto, Della Penna, S. L., Fernandez, Belisario Enrique, Kouyoumdzian, Nicolás Martín, Kravetz, Maria Cecilia, Roson, Maria Ines, Rukavina Mikusic, Natalia Lucía   +6 more
core   +3 more sources

Solving the Amyloid Paradox: Unveiling the Complex Pathogenicity of Amyloid Fibrils

Aggregate, EarlyView.
This review addresses the gap between strong evidence for the involvement of amyloid fibrils in neurodegeneration and the failure of anti‐amyloid therapies, a phenomenon herein termed the “amyloid paradox.” To address this paradox, we provide a comprehensive summary of the current understanding of fibrils' pathogenic properties and mechanisms ...
Maksim I. Sulatsky, Olesya V. Stepanenko, Olga V. Stepanenko, Anna I. Sulatskaya   +3 more
wiley   +1 more source

Role of Rac1 GTPase in NADPH oxidase activation and cognitive impairment following cerebral ischemia in the rat. [PDF]

PLoS ONE, 2010
Recent work by our laboratory and others has implicated NADPH oxidase as having an important role in reactive oxygen species (ROS) generation and neuronal damage following cerebral ischemia, although the mechanisms controlling NADPH oxidase in the brain ...
Limor Raz, Quan-Guang Zhang, Cai-feng Zhou, Dong Han, Priya Gulati, Li-cai Yang, Fang Yang, Rui-min Wang, Darrell W Brann   +8 more
doaj   +1 more source

Reaction of the NAD(P)H:flavin oxidoreductase from Escherichia coli with NADPH and riboflavin: identification of intermediates [PDF]

Biochemistry, American Chemical Society, 1998, 37, pp.11879-87, 2014
Flavin reductase catalyzes the reduction of free flavins by NAD(P)H. As isolated, Escherichia coli flavin reductase does not contain any flavin prosthetic group but accommodates both the reduced pyridine nucleotide and the flavin substrate in a ternary complex prior to oxidoreduction.
arxiv  

Genetic targeting or pharmacologic inhibition of NADPH oxidase nox4 provides renoprotection in long-term diabetic nephropathy.

Journal of the American Society of Nephrology, 2014
Diabetic nephropathy may occur, in part, as a result of intrarenal oxidative stress. NADPH oxidases comprise the only known dedicated reactive oxygen species (ROS)-forming enzyme family.
J. Jha, S. Gray, D. Barit, J. Okabe, A. El-Osta, T. Namikoshi, V. Thallas‐Bonke, K. Wingler, C. Szyndralewiez, F. Heitz, R. Touyz, M. Cooper, H. Schmidt, K. Jandeleit-Dahm   +13 more
semanticscholar   +1 more source

VAS2870 is a pan-NADPH oxidase inhibitor [PDF]

Cellular and Molecular Life Sciences, 2012
In their detailed review ‘‘NADPH oxidases as therapeutic targets in ischemic stroke’’ [1], Kahles and Brandes discuss the pathological roles of NADPH oxidases in ischemic brain injury and the therapeutic implications. In agreement with the authors, we consider inhibition of NADPH oxidases as a promising strategy to treat ischemic stroke.
Kirstin Wingler, Sebastian A. Altenhoefer, Pamela W. M. Kleikers, Kim A. Radermacher, Christoph Kleinschnitz, Harald H. H. W. Schmidt   +5 more
openaire   +4 more sources

Architected Microalgae‐Based Matter via 3D Printing: Properties, Printing Techniques, and Applications

Advanced NanoBiomed Research, EarlyView.
Microalgae are emerging as sustainable and economical bioresources that can be utilized as bioinks for creating constructs with intriguing functionalities. This review discusses the properties and applications of microalgae, providing a comprehensive review of recent advancements and challenges in 3D‐printed microalgae‐based constructs for various ...
Yiwei Zou, Jiuhong Yi, Yunlu Dai, Iek Man Lei   +3 more
wiley   +1 more source

NADPH oxidase deficient mice develop colitis and bacteremia upon infection with normally avirulent, TTSS-1- and TTSS-2-deficient Salmonella Typhimurium. [PDF]

PLoS ONE, 2013
Infections, microbe sampling and occasional leakage of commensal microbiota and their products across the intestinal epithelial cell layer represent a permanent challenge to the intestinal immune system. The production of reactive oxygen species by NADPH
Boas Felmy, Pascal Songhet, Emma Marie Caroline Slack, Andreas J Müller, Marcus Kremer, Laurye Van Maele, Delphine Cayet, Mathias Heikenwalder, Jean-Claude Sirard, Wolf-Dietrich Hardt   +9 more
doaj   +1 more source

Regulation of reactive oxygen species during plant immunity through phosphorylation and ubiquitination of RBOHD. [PDF]

, 2020
Production of reactive oxygen species (ROS) is critical for successful activation of immune responses against pathogen infection. The plant NADPH oxidase RBOHD is a primary player in ROS production during innate immunity. However, how RBOHD is negatively
Castro, Bardo, Coaker, Gitta, Dinesh-Kumar, Savithramma P, Lal, Neeraj K, Lee, DongHyuk, Lin, Zuh-Jyh Daniel, Liu, Jun, Ma, Shisong, Toruño, Tania   +8 more
core   +1 more source