Results 121 to 130 of about 424,484 (404)
Vascular Functions of NADPH Oxidases [PDF]
Hypertension, 2010 NADPH oxidases belong to a group of enzymes that generate reactive oxygen species (ROS) by electron transfer from NADPH to molecular oxygen. The product of this reaction is the superoxide anion (O2−), which undergoes secondary reactions. O2− inactivates NO to yield peroxynitrite and spontaneously or under catalysis of superoxide dismutases reacts to ...
openaire +2 more sources
Redox Biology, 2017 Histone deacetylase 6 (HDAC6) likely is important in inflammatory diseases. However, how HDAC6 exerts its effect on inflammatory processes remains unclear.
Gi Soo Youn +4 more
doaj
PLoS ONE, 2014 Background and Objectives Blood-brain barrier (BBB) dysfunction is an integral feature of neurological disorders and involves the action of multiple proinflammatory cytokines on the microvascular endothelial cells lining cerebral capillaries.
K. Rochfort +3 more
semanticscholar +1 more source
NADPH Oxidases in Cardiovascular Health and Disease [PDF]
Antioxidants & Redox Signaling, 2006 Increased oxidative stress plays an important role in the pathophysiology of cardiovascular diseases such as hypertension, atherosclerosis, diabetes, cardiac hypertrophy, heart failure, and ischemia-reperfusion. Although several sources of reactive oxygen species (ROS) may be involved, a family of NADPH oxidases appears to be especially important for ...
Cave, A C +6 more
openaire +4 more sources
Monitoring of the Membrane Potential in Proteoliposomes with Incorporated Cytochrome-c Oxidase Using the Fluorescent Dye Indocyanine [PDF]
Ivashchuk-Kienbaum Yu. A. J. Membrane Biol. 151, 247-259, 1996, 2002 A method has been developed to monitor changes of the membrane potential across vesicle membranes in real time. Using the potential-sensitive fluorescent dye indocyanine and on the basis of water/lipid redistribution model, a calculation procedure has been introduced to estimate the membrane potential in vesicles with incorporated cytochrome-c oxidase.
arxiv
Deprenyl, an old drug with new anticancer potential: Mini review [PDF]
arXiv, 2021 The anticancer potential of monoamine oxidase (MAO) was observed in pre-clinical assays conducted with cell cultures and animals. L-Deprenyl (DEP) causes apoptosis in melanoma, leukemia and mammary cells. High-dose DEP has shown toxicity in mammary and pituitary cancers, as well as in monoblastic leukemia, in rats.
arxiv
Functional Effect of the p22phox -930A/G Polymorphism on p22phox Expression and NADPH Oxidase Activity in Hypertension [PDF]
, 2004 Oxidative stress induced by superoxide is implicated in hypertension. NADPH oxidase is the main source of superoxide in phagocytic and vascular cells, and the p22phox subunit is involved in NADPH oxidase activation.
Beloqui, O. (Óscar) +6 more
core
Vitamins Reverse Endothelial Dysfunction Through Regulation of eNOS and NAD(P)H Oxidase Activities [PDF]
, 2003 Antioxidant vitamins C and E have protective properties in genetic hypertension associated with enhanced oxidative stress. This study investigated whether vitamins C and/or E modulate vascular function by regulating enzymatic activities of endothelial ...
Bayraktutan, Ulvi +2 more
core +2 more sources
Electron and proton transport by NADPH oxidases [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2005 The NADPH oxidase is the main weapon of phagocytic white blood cells that are the first line of defence of our body against invading pathogens, and patients lacking a functional oxidase suffer from severe and recurrent infections. The oxidase is a multisubunit enzyme complex that transports electrons from cytoplasmic NADPH to molecular oxygen in order ...
Demaurex, Nicolas, Petheö, Gábor L
openaire +4 more sources
The Anatomical Record, EarlyView.Abstract Hibernation induces significant molecular and cellular adaptations in the retina to maintain function under reduced metabolic conditions. This study aimed to investigate the expression of neuronal, synaptic, and glial markers in the retina of Spermophilus xanthoprymnus during pre‐hibernation and hibernation periods using immunohistochemical ...
Mehmet Özbek +5 more
wiley +1 more source