Results 131 to 140 of about 442,921 (391)
Circulation Research, 2009 Over the last decade, the NADPH oxidases have been recognized as an important source of reactive oxygen species (ROS) involved in both normal physiologic redox-dependent processes, and in the generation of oxidative stress, with a role in the development of cardiovascular disease.
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Animal Models and Experimental Medicine, EarlyView.The alleviation of asthma by polydatin is dependent on the blockage of the toll‐like receptor 4 (TLR4)/P2X7R synergy in macrophages. The blockage of the TLR4/P2X7R synergy results in decreased release and secretion of interleukin‐1β (IL‐1β) and IL‐18. In epithelial cells, low IL‐1β and IL‐18 levels inhibit mitochondrial damage and apoptosis.
Guangxing Li +9 more
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NADPH oxidases: Current aspects and tools
Redox Biology, 2020 Reactive oxygen species (ROS) have been shown or at least suggested to play an essential role for cellular signaling as second messengers. NADPH oxidases represent a source of controlled ROS formation. Accordingly, understanding the role of individual NADPH oxidases bears potential to interfere with intracellular signaling cascades without disturbing ...
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Animal Research and One Health, EarlyView.Dietary RSO supplementation improved growth performance, simultaneously enriched n‐3 polyunsaturated fatty acids (n‐3 PUFA), and enhanced antioxidant capacity in Pekin ducks, which suggested that RSO has the potential to be a novel n‐3 PUFA source and an antioxidant for Pekin ducks to generate animal functional foods.
Lei Zhuang +10 more
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PLoS ONE, 2015 Reactive oxygen species (ROS) promote the germination of several seeds, and antioxidants suppress it. However, questions remain regarding the role and production mechanism of ROS in seed germination. Here, we focused on NADPH oxidases, which produce ROS.
Yushi Ishibashi +8 more
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Animal Research and One Health, EarlyView.Myo‐inositol alleviates oxidative stress in dairy cow mammary epithelial cells via the Sirt5/Nrf2 pathway to promote mitochondrial fusion. This graphical abstract was created with BioRender.com. ABSTRACT High‐yielding dairy cows are susceptible to mammary gland oxidative stress due to prolonged intensive lactation, leading to redox imbalance.
Yufei Zhang +8 more
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CBL1‐CIPK26‐mediated phosphorylation enhances activity of the NADPH oxidase RBOHC, but is dispensable for root hair growth [PDF]
, 2018 Xinxin Zhang +7 more
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Arthritis &Rheumatology, EarlyView.Objective Cardiovascular events are major determinants of morbidity and mortality in systemic lupus erythematosus (SLE), particularly in patients with renal involvement. Although oxidative stress has been implicated in driving vascular and renal damage in SLE, the specific mechanisms remain unclear.
Matteo Becatti +13 more
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Differential role for ERK1/2 and p38 MAP kinases in activating NADPH-oxidase and phospholipase A2 in angiotensin II-stimulated phagocytes [PDF]
, 2002 I HAZANHALLEVY
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Dysregulation of U12‐Type Splicing in Lupus Neutrophils
Arthritis &Rheumatology, Accepted Article.Abstract. Objective Neutrophil dysfunction is a hallmark of systemic lupus erythematosus (SLE), but its molecular basis remains unclear. This study explores transcriptional and post‐transcriptional changes in low‐density granulocytes (LDGs), a proinflammatory neutrophil subset expanded in SLE, focusing on NADPH oxidase (Nox) function and minor intron ...
Luz P. Blanco +11 more
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